Cargo of small extracellular vesicles from neuronal origin shows progression of dementia in individuals with Down syndrome
Por:
Ledreux, A, Carmona-Iragui, M, Videla, L, Benejam, B, Barroeta, I, Lleó, A, Alcolea, D, Fortea, J
Publicada:
1 jun 2025
Resumen:
Introduction: Individuals with Down syndrome (DS) are at an ultra-high risk of developing Alzheimer's disease (AD). Diagnosis of AD onset in people with DS can be challenging due to the variable degrees of intellectual disability and cognitive impairment among individuals. Methods: Plasma samples from individuals with DS diagnosed with AD dementia (n = 33), prodromal AD (n = 31), or cognitively stable (n = 43) were enriched for neuron-derived extracellular vesicles (NDEV) using immunocapture with the L1CAM antibody. We used single-molecule array technology to quantify amyloid-beta (A beta) peptides, Tau, phosphorylated Tau, neurofilament light chain (NfL), and synaptosomal-associated protein 25 (SNAP25) across diagnostic groups. Results: NDEV levels of A beta 40, A beta 42, Tau, pTauT181, pTauT231, NfL, and SNAP25 were significantly higher in people with DS diagnosed with prodromal AD compared to those with no cognitive decline. Middle-aged or older women had higher levels of NDEV biomarkers compared to males. Discussion: NDEV biomarker levels can inform on the onset of AD in individuals with DS.
Filiaciones:
Ledreux, A:
Univ Colorado, Sch Med, Dept Neurosurg, Anschutz Med Campus,12700 E 19th Ave, Aurora, CO 80045 USA
Carmona-Iragui, M:
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Videla, L:
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Benejam, B:
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Barroeta, I:
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Lleó, A:
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Alcolea, D:
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fortea, J:
Univ Autonoma Barcelona, Hosp St Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Madrid, Spain
Fundacio Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Green Submitted, hybrid
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