Dietary patterns and exposure to non-persistent endocrine-disrupting chemicals during pregnancy
Por:
Warkentin, S, Márquez, S, Vespalcová, H, Knox, B, Gascon, M, Güil-Oumrait, N, González-Palacios, S, Roig, MDG, Lassale, C, Llurba, E, Rolland, M, Sakhi, AK, Thomsen, C, Vioque, J, Bustamante, M, Sunyer, J, Vrijheid, M
Publicada:
1 ago 2025
Ahead of Print:
1 jun 2025
Resumen:
Background: Exposure to non-persistent endocrine disrupting chemicals (EDCs) is widespread, causing various adverse health effects, especially during pregnancy. Diet is a major source of EDCs and the identification of dietary patterns that give rise to higher exposure levels is crucial. We aimed to explore the relationship between dietary patterns during pregnancy and exposure to non-persistent EDCs. Methods: We included 640 pregnant women from the Barcelona Life Study Cohort (BiSC), Spain. Using food frequency questionnaires (2nd trimester), we estimated ultraprocessed food (UPF) consumption and Mediterranean diet adherence, and derived data-driven dietary patterns. Metabolites of phthalates, 1,2-cyclohexane dicarboxylic acid di(isononyl) ester (DINCH), chlorpyrifos and pyrethroid, polycyclic aromatic hydrocarbons (PAHs, including phenanthrenes), and organophosphates, and parent compounds of phenols and parabens were measured in weekly urine pools (3rd trimester). Associations between dietary patterns and EDCs were evaluated through multivariable linear regressions. Results: Higher compliance with a "Vegetarian" pattern or the Mediterranean diet was associated with lower levels of some of the phthalate metabolites (e.g., di-iso-nonyl phthalates [Geometric mean ratio (GMR) per unit increases in the "Vegetarian" score = 0.97, 95 %CI 0.95, 1.00]). Conversely, "Western" and "Animal protein" patterns, and UPF intake were associated with higher PAHs (e.g., "Western" and 2-Hydroxynaphthalene [GMR (95 %CI) 1.07(1.01, 1.13)]), pesticides (e.g., "Animal protein" and 3-Phenoxybenzoic acid [1.15(1.01, 1.32]), and phthalates metabolites levels (e.g., UPF and Monoethyl phthalate [1.05(1.01, 1.09)]). No association remained significant after correcting for multiple testing. Conclusions: Following a plant-based diet may help reduce the exposure to certain phthalate and organophosphate metabolites, whereas higher consumption of foods from animal origin and high in fat/sugar/salt may increase exposure to PAHs, pesticides, and phthalates metabolites in pregnancy.
Filiaciones:
Warkentin, S:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Márquez, S:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Vespalcová, H:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Knox, B:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Gascon, M:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Fdn Inst Univ Recerca Atencio Primaria Salut Jordi, Unitat Suport Recerca Catalunya Cent, Manresa, Spain
Güil-Oumrait, N:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
González-Palacios, S:
Univ Miguel Hernandez, Inst Invest Sanitaria & Biomed Alicante UMH ISABIA, Alicante, Spain
Roig, MDG:
Inst Salud Carlos III, Primary Care Intervent Prevent Maternal & Child Ch, RD21-0012-0003, Madrid, Spain
Univ Barcelona, Hosp St Joan De Deu, Fetal Med Res Ctr, BCNatal, Barcelona, Spain
Univ Barcelona, Hosp Clin, Barcelona, Spain
Inst Recerca St Joan de Deu, Barcelona, Spain
Lassale, C:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Inst Salud Carlos III, Consortium Biomed Res Pathophysiol Obes & Nutr CIB, Madrid, Spain
Llurba, E:
Inst Salud Carlos III, Primary Care Intervent Prevent Maternal & Child Ch, RD21-0012-0003, Madrid, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, Dept Obstet & Gynaecol, Barcelona, Spain
Rolland, M:
Univ Grenoble Alpes, Inst Adv Biosci, Team Environm Epidemiol Appl Reprod & Resp Hlth, Inserm,U1209,CNRS,UMR 5309, F-38000 Grenoble, France
Sakhi, AK:
Norwegian Inst Publ Hlth, Dept Food Safety, Oslo, Norway
Thomsen, C:
Norwegian Inst Publ Hlth, Dept Food Safety, Oslo, Norway
Vioque, J:
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Miguel Hernandez, Inst Invest Sanitaria & Biomed Alicante UMH ISABIA, Alicante, Spain
Bustamante, M:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Sunyer, J:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
IMIM Hosp Mar Med Res Inst, Barcelona, Catalonia, Spain
Vrijheid, M:
ISGlobal, Barcelona, Spain
Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Madrid, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Green Submitted, gold
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