Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson's Disease
Por:
Santos-Garcia, D, Castro, ES, Fonticoba, TD, Panceiras, MJF, Enriquez, JGM, Gonzalez, JMP, Bartolome, CC, Planellas, LL, Caldentey, JG, Caballol, N, Legarda, I, Lopez, IC, Manzanares, LL, Rivera, MAA, Catalan, MJ, Nogueira, V, Borrue, C, Sauco, MA, Vela, L, Cubo, E, Castrillo, JCM, Alonso, PS, Losada, MGA, Ariztegui, NL, Gaston, MI, Kulisevsky, J, Pagonabarraga, J, Seijo, M, Martinez, JR, Valero, C, Kurtis, M, Ardura, JG, Prieto, C, Mir, P, Martinez-Martin, P
Publicada:
1 nov 2021
Ahead of Print:
1 oct 2020
Resumen:
Introduction: The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients. Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson's disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems. Results: The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 +/- 28.8 vs 132.8 +/- 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 +/- 14 vs 13 +/- 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 +/- 0.5 vs 3.9 +/- 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015-1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009-1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments. Conclusion: Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients.
Filiaciones:
Santos-Garcia, D:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Castro, ES:
Complejo Hosp Univ Ferrol CHUF, Hosp Arquitecto Marcide, Ferrol, A Coruna, Spain
Complejo Hosp Univ Ferrol CHUF, Hosp Naval, Ferrol, A Coruna, Spain
Fonticoba, TD:
Complejo Hosp Univ Ferrol CHUF, Hosp Arquitecto Marcide, Ferrol, A Coruna, Spain
Complejo Hosp Univ Ferrol CHUF, Hosp Naval, Ferrol, A Coruna, Spain
Panceiras, MJF:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Enriquez, JGM:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Gonzalez, JMP:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Bartolome, CC:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Planellas, LL:
Hosp Clin Barcelona, Barcelona, Spain
Caldentey, JG:
Ctr Neurol Oms 42, Palma de Mallorca, Spain
Caballol, N:
Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
Legarda, I:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Lopez, IC:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Manzanares, LL:
Hosp La Princesa, Madrid, Spain
Rivera, MAA:
Hosp Gen Hospitalet, Consorci Sanitari Integral, Barcelona, Spain
Catalan, MJ:
Hosp Univ Clin San Carlos, Madrid, Spain
Nogueira, V:
Hosp Costa Burela, Lugo, Spain
Borrue, C:
Hosp Infanta Sofia, Madrid, Spain
Sauco, MA:
Hosp Gen Univ Elche, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Castrillo, JCM:
Hosp Univ Ramon y Cajal, Madrid, Spain
Alonso, PS:
Hosp Univ Puerta de Hierro, Madrid, Spain
Losada, MGA:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain
Ariztegui, NL:
Complejo Hosp Toledo, Toledo, Spain
Gaston, MI:
Complejo Hosp Navarra, Pamplona, Spain
Kulisevsky, J:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Pagonabarraga, J:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Seijo, M:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Martinez, JR:
Hosp Univ Donostia, San Sebastian, Spain
Valero, C:
Hosp Arnau Vilanova, Valencia, Spain
Kurtis, M:
Hosp Ruber Int, Madrid, Spain
Ardura, JG:
Hosp Univ Lucus Augusti HULA, Lugo, Spain
Prieto, C:
Hosp Rey Juan Carlos, Madrid, Spain
Mir, P:
Univ Seville, Hosp Univ Virgen del Rocio, Serv Neurol & Neurofisiol Clin,CSIC, Inst Biomed Sevilla,Unidad Trastornos Movimiento, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Martinez-Martin, P:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
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