A Comprehensive Analysis of the Abdominal Aortic Aneurysm Growth Rate in the Spanish Population
Por:
Peypoch, O, Juscafresa, LC, Vega-Méndez, A, Lobato-Delgado, B, Fité, J, Soto, B, Nieto, L, Estadella, MD, Uribezubia, A, Romero, JM, Plana, E, Miralles, M, Clarà, A, Dilmé, J, Soria, JM, Camacho, M, Martinez-Perez, A, Sabater-Lleal, M
Publicada:
3 jul 2025
Resumen:
Objective: The risk of Abdominal Aortic Aneurysm (AAA) rupture is associated with the aneurysm size and growth rate. This study aims to provide a global description of growth rates per intervals of AAA diameter size for individuals in the Spanish population, to understand possible comorbidities associated with growth rate variability, and to assess practitioners on safe follow-up visits for AAA patients. Methods: We present the Triple-A Barcelona Study (TABS), a new hospital-based longitudinal study recruiting consecutive individuals with AAAs in Barcelona. So far, 469 individuals with measurements of the abdominal aortic diameter, along with anthropometric, clinical information, and blood samples for most follow-up visits, have been recruited. Statistical modeling was performed to identify the most relevant predictors of the diameter size and expansion in individuals with AAAs using linear mixed-effect models. Results: The average growth rate per interval was 0.78 (2.34) mm/year for aneurysms with an initial diameter between 30 and 40 mm, 1.22 (3.34) mm/year for aneurysms with an initial diameter between 40 and 50 mm, and 4.12 (5.09) mm/year for aneurysms with an initial diameter equal to or greater than 50 mm. The main factors determining the growth rate beyond the aortic diameter are sex and related comorbidities (COPD and DM). The estimated time to reach the surgical threshold for individuals with small aneurysms exceeded 10 years, on average. Conclusions: Overall, this study serves as a promising step towards the development of better prediction tools to assess clinical decisions in AAA patients in the Spanish population and to guide future screening policies.
Filiaciones:
Peypoch, O:
Hosp Santa Creu & Sant Pau, Dept Vasc & Endovasc Surg, Barcelona 08025, Spain
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Dept Cirurgia & Ciencies Morfolog, Barcelona 08193, Spain
Juscafresa, LC:
Hosp Del Mar Barcelona, Vasc Surg Dept, Barcelona 08003, Spain
Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona 08003, Spain
Vega-Méndez, A:
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Lobato-Delgado, B:
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Fité, J:
Hosp Santa Creu & Sant Pau, Dept Vasc & Endovasc Surg, Barcelona 08025, Spain
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Soto, B:
Hosp Santa Creu & Sant Pau, Dept Vasc & Endovasc Surg, Barcelona 08025, Spain
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Nieto, L:
Hosp Del Mar Barcelona, Vasc Surg Dept, Barcelona 08003, Spain
Estadella, MD:
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Uribezubia, A:
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Romero, JM:
Hosp Santa Creu & Sant Pau, Dept Vasc & Endovasc Surg, Barcelona 08025, Spain
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Plana, E:
Inst Invest Sanitaria La Fe, Grp Acreditado Hemostasia Trombosis Arterioscleros, Valencia 46026, Spain
Miralles, M:
Inst Invest Sanitaria La Fe, Grp Acreditado Hemostasia Trombosis Arterioscleros, Valencia 46026, Spain
Hosp Univ & Politecn La Fe, Serv Angiol & Cirugia Vasc, Valencia 46026, Spain
Univ Valencia, Fac Med, Valencia 46010, Spain
Clarà, A:
Hosp Del Mar Barcelona, Vasc Surg Dept, Barcelona 08003, Spain
Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona 08003, Spain
Ctr Invest Biomed Red Enfermedades CardioVasc Cibe, Madrid 28029, Spain
Dilmé, J:
Hosp Santa Creu & Sant Pau, Dept Vasc & Endovasc Surg, Barcelona 08025, Spain
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Univ Autonoma Barcelona UAB, Dept Cirurgia & Ciencies Morfolog, Barcelona 08193, Spain
Ctr Invest Biomed Red Enfermedades CardioVasc Cibe, Madrid 28029, Spain
Soria, JM:
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid 28209, Spain
Camacho, M:
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades CardioVasc Cibe, Madrid 28029, Spain
Martinez-Perez, A:
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid 28209, Spain
Sabater-Lleal, M:
Inst Recerca St Pau IR ST PAU, Unit Genom Complex Dis, Barcelona 08041, Spain
Ctr Invest Biomed Red Enfermedades Raras CIBERER, Madrid 28209, Spain
Karolinska Inst, Ctr Mol Med, Cardiol Unit, Dept Med, S-17176 Stockholm, Sweden
Green Submitted, gold
|