Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study
Por:
Perez-Sáez, MJ, Melilli, E, Arias, M, Franco, A, Martinez, R, Sancho, A, Molina, M, Facundo, C, Polanco, N, López, V, Mazuecos, A, Cabello, S, García, MEG, Suárez, ML, Auyanet, I, Espi, J, Falcón, TG, Ruiz, JC, Galeano, C, Artamendi, M, Rodríguez-Ferrero, ML, Portolés, JM, Santana, MA, Martín-Moreno, PL, Arhda, N, Calvo, M, Mendiluce, A, Macía, M, Pérez-Tamajón, ML, de Teresa, J, Gascó, B, Soriano, S, Tabernero, G, de la Vara, L, Ramos, AM, Martínez, R, de Espinosa, EM, Zalve, JL, Pascual, J, Rodriguez-Mañas, L, Gutiérrez-Dalmau, A, Moreso, F
Publicada:
24 jun 2025
Resumen:
Frailty is a frequent condition among kidney transplant candidates (KTc) that confers poor outcomes after transplantation. We aimed to establish frailty prevalence in a representative sample of KTc in Spain. We conducted a multicenter cross-sectional study including 1194 KTc >= 50 years. Frailty was assessed by the FRAIL scale. Mean age was 64.2 years; 38.4% were female. Median Charlson comorbidity index (CCI) was 6 [4-7] and the total number of medications was 9 [7-12]. We found that 8.2% of patients were frail and 41.5% were pre-frail. Frailty was more frequent among females (60.2% of frail vs. 32.8% of robust; p < 0.001), hemodialysis patients (74.5% of frail vs. 67.1% of robust; p = 0.02), and those with a high burden of disease (54.6% of frail patients with CCI >6 vs. 29.3% of robust; p < 0.001). The multivariable analysis confirmed that frailty was associated with the female sex (OR 3.9 [2.5-6.2]); higher CCI (>6 OR 2.9 [1.6-54]); and the number of medications (OR -per medication- 1.13 [1.07-1.2]). Almost 50% of KTc in Spain are pre-frail or frail. Frailty is more prevalent between women and patients with high comorbidity burden. Identifying those candidates at risk is essential to establish risks and implement strategies to minimize them.
Filiaciones:
Perez-Sáez, MJ:
Hosp del Mar, Dept Nephrol, RICORS2040 RD21 0005 0022, Barcelona, Spain
Hosp del Mar, Res Inst, Barcelona, Spain
Melilli, E:
Hosp Univ Bellvitge, Nephrol Dept, Lhospitalet De Llobregat, Barcelona, Spain
Arias, M:
Hosp Clin Barcelona, Nephrol Dept, Barcelona, Spain
Franco, A:
Hosp Gen Univ, Nephrol Dept, Alicante, Spain
Martinez, R:
Hosp Univ Infanta Cristina, Nephrol Dept, Badajoz, Spain
Sandoz Farmaceut SA, Med Dept, Madrid, Spain
Sancho, A:
Hosp Univ Doctor Peset, Nephrol Dept, Valencia, Spain
Molina, M:
Hosp Univ Germans Trias i Pujol, Nephrol Dept, RICORS2040, Barcelona, Spain
Facundo, C:
Inst Recerca St Pau IR St Pau, Nephrol Dept, Fundacio Puigvert, RICORS2040, Barcelona, Spain
Polanco, N:
Hosp 12 Octubre, Nephrol Dept, Madrid, Spain
López, V:
Hosp Reg Univ Malaga, Nephrol Dept, Malaga, Spain
Univ Malaga, Inst Biomed Invest Malaga IBIMA, Natl Network Kidney Res RICORS2040 RD21 0005 0012, Malaga, Spain
Mazuecos, A:
Hosp Univ Puerta del Mar, Nephrol Dept, Cadiz, Spain
Cabello, S:
Hosp Univ Son Espases, Nephrol Dept, Palma De Mallorca, Spain
García, MEG:
Hosp Univ La Paz, Nephrol Dept, Madrid, Spain
Suárez, ML:
Hosp Univ Cent Asturias, Nephrol Dept, Oviedo, Spain
Auyanet, I:
Complejo Hosp Insular Gran Canaria, Nephrol Dept, Las Palmas Gran Canaria, Spain
Espi, J:
Hosp Univ & Politecn la Fe, Nephrol Dept, Valencia, Spain
Falcón, TG:
Complejo Hosp Univ A Coruna, Nephrol Dept, La Coruna, Spain
Ruiz, JC:
Hosp Univ Marques de Valdecilla, Nephrol Dept, Inst Invest Valdecilla Idival, Santander, Spain
Galeano, C:
Hosp Univ Ramon Y Cajal, Nephrol Dept, Inst Ramon Y Cajal Invest Sanitaria IRyCIS, Madrid, Spain
Artamendi, M:
Hosp San Pedro, Nephrol Dept, La Rioja, Spain
Rodríguez-Ferrero, ML:
Hosp Gen Univ Gregorio Maranon, Nephrol Dept, Madrid, Spain
Portolés, JM:
Hosp Univ Puerta de Hierro, Nephrol Dept, Madrid, Spain
Santana, MA:
Hosp Univ Cruces, Nephrol Dept, Baracaldo, Bizkaia, Spain
Martín-Moreno, PL:
Clin Univ Navarra, Navarra Inst Hlth Res IdiSNA, Nephrol Dept, Pamplona, Spain
Arhda, N:
Hosp Clin Univ Santiago, Nephrol Dept, Santiago De Compostela, Spain
Calvo, M:
Hosp Clin San Carlos, Nephrol Dept, Madrid, Spain
Mendiluce, A:
Hosp Clin Univ Valladolid, Nephrol Dept, Valladolid, Spain
Macía, M:
Hosp Virgen de la Candelaria, Nephrol Dept, Santa Cruz De Tenerife, Spain
Pérez-Tamajón, ML:
Hosp Univ Canarias, Nephrol Dept, Santa Cruz De Tenerife, Spain
de Teresa, J:
Hosp Univ Virgen de las Nieves, Nephrol Dept, Granada, Spain
Gascó, B:
Hosp Virgen del Rocio, Nephrol Dept, Seville, Spain
Soriano, S:
Hosp Univ Reina Sofia, Nephrol Dept, Cordoba, Spain
Tabernero, G:
Hosp Univ Salamanca, Nephrol Dept, Inst Invest Biomed Salamanca IBSAL, Salamanca, Spain
de la Vara, L:
Complejo Hosp Gen Univ Albacete, Nephrol Dept, Albacete, Spain
Ramos, AM:
Fdn Jimenez Diaz, Nephrol Dept, Madrid, Spain
Martínez, R:
Sandoz Farmaceut SA, Med Dept, Madrid, Spain
de Espinosa, EM:
Sandoz Farmaceut SA, Med Dept, Madrid, Spain
Zalve, JL:
Sandoz Farmaceut SA, Med Dept, Madrid, Spain
Pascual, J:
Hosp 12 Octubre, Nephrol Dept, Madrid, Spain
Rodriguez-Mañas, L:
Hosp Univ Getafe, Geriatr Dept, Madrid, Spain
Gutiérrez-Dalmau, A:
Hosp Univ Miguel Servet, Nephrol Dept, Zaragoza, Spain
Moreso, F:
Hosp Univ Gen Vall dHebron, Nephrol Dept, Barcelona, Spain
Green Submitted, gold
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