Dysphagia in Parkinsons disease. A 5-year follow-up study
Por:
Santos-García, D, Fonticoba, TD, Jesús, S, Cosgaya, M, Caldentey, JG, Caballol, N, Legarda, I, Vara, JH, Cabo, I, Manzanares, LL, Aramburu, IG, Rivera, MAA, Mayordomo, VG, Nogueira, V, García-Soto, JD, Borrué, C, Vila, BS, Sauco, MA, Vela, L, Escalante, S, Cubo, E, Mendoza, Z, Pareés, I, Alonso, PS, Losada, MGA, Ariztegui, NL, Gastón, I, Kulisevsky, J, Seijo, M, Valero, C, Redondo, RA, Ordás, C, Menendez-González, M, Mcafee, D, Martinez-Martin, P, Mir, P
Publicada:
1 jun 2025
Ahead of Print:
1 feb 2025
Resumen:
Background and objective Dysphagia at time of diagnosis suggests atypical parkinsonism instead Parkinsons disease (PD). Our aim was to analyze the frequency of dysphagia in patients with early PD comparing with a control group and to identify related factors. Patients and methods Patients with early PD (<= 2 years from symptoms onset) who were recruited from January/2016 to November/2017 (baseline visit; V0) and evaluated annually for 5 years from the Spanish cohort COPPADIS were included in this prospective study. Controls were assessed at baseline and at 2-, 4-, and 5-year follow-up. Dysphagia was defined as a score >= 1 in the item 20 of the Non-Motor Symptoms Scale (NMSS). Results Dysphagia was more frequent at baseline in PD patients (19.6% [36/184]; 62.3 +/- 8.3 years old; 56.8% males) than in controls (5.3% [11/206]; 60.9 +/- 8.3 years old; 50% males) (p < 0.0001) and in all visits as well (p < 0.0001). A worse quality of sleep (Parkinsons Disease Sleep Scale; OR = 0.974; p = 0.005), a greater impulse-control behavior (ICB) (Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale; OR = 1.066; p = 0.014), and non-motor symptoms burden (Non-Motor Symptoms Scale; OR = 1.016; p = 0.021) were independent factors associated with dysphagia at baseline. In those subjects with dysphagia, no differences were observed between patients and controls in the mean NMSS-item 20 overtime, and it didnt change throughout the follow-up. Conclusion Dysphagia was frequent in early PD patients compared to controls. However, it was minor and did not progress over time. Sleep, ICB, and non-motor symptoms burden were related to dysphagia.
Filiaciones:
Santos-García, D:
CHUAC, HUAC, Dept Neurol, C As Xubias 84, La Coruna 15006, Spain
Inst Invest Biomed A Coruna, Grp Invest Enfermedad Parkinson & Otros Trastornos, INIBIC, La Coruna, Spain
Hosp San Rafael, La Coruna, Spain
Fdn Degen, La Coruna, Spain
Fonticoba, TD:
CHUF Complejo Hosp Univ Ferrol, La Coruna, Spain
Jesús, S:
Univ Seville, Hosp Univ Virgen Rocio, Serv Neurol & Neurofisiol Clin,CSIC, Unidad Trastornos Movimiento,Inst Biomed Sevilla, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Cosgaya, M:
Hosp Clin Barcelona, Barcelona, Spain
Caldentey, JG:
Ctr Neurol Oms 42, Palma de Mallorca, Spain
Caballol, N:
Hosp Moises Broggi Sant Joan Despi, Consorci Sanitari Integral, Barcelona, Spain
Legarda, I:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Vara, JH:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Hosp Univ Vall dHebron, Barcelona, Spain
Cabo, I:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Manzanares, LL:
Hosp Univ La Princesa, Madrid, Spain
Aramburu, IG:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Hosp Univ Marques De Valdecilla, IDIVAL, Santander, Spain
Rivera, MAA:
Consorci Sanit Integral, Hosp Gen Lhosp, Barcelona, Spain
Mayordomo, VG:
Vithas Madrid La Milagrosa Univ Hosp, Vithas Hosp Grp, Inst Neurosci, Neurol Dept, Madrid, Spain
Nogueira, V:
Hosp Univ Lucus Augusti, Lugo, Spain
García-Soto, JD:
Hosp Univ Virgen Macarena, Seville, Spain
Borrué, C:
Hosp Infanta Sofia, Madrid, Spain
Vila, BS:
Inst Catala Salut, IAS, Girona, Spain
Sauco, MA:
Hosp Gen Univ Elche, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Escalante, S:
HTVC, Tortosa, Tarragona, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Mendoza, Z:
Hosp Univ Canarias, Santa Cruz De Tenerife, Spain
Pareés, I:
Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain
Alonso, PS:
Hosp Univ Puerta de Hierro, Madrid, Spain
Losada, MGA:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain
Ariztegui, NL:
Complejo Hosp Toledo, Toledo, Spain
Gastón, I:
Complejo Hosp Navarra Pamplona, Pamplona, Spain
Kulisevsky, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Seijo, M:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Valero, C:
Hosp Arnau Vilanova, Valencia, Spain
Redondo, RA:
Hosp Univ Lucus Augusti, Lugo, Spain
Ordás, C:
Hosp Rey Juan Carlos, Madrid, Spain
Menendez-González, M:
Hosp Univ Cent Asturias, Oviedo, Spain
Mcafee, D:
Univ Maryland, Sch Med, Baltimore, MD USA
Martinez-Martin, P:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Mir, P:
Univ Seville, Hosp Univ Virgen Rocio, Serv Neurol & Neurofisiol Clin,CSIC, Unidad Trastornos Movimiento,Inst Biomed Sevilla, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Univ Seville, Fac Med, Dept Med, Seville, Spain
Green Submitted, Green Accepted, hybrid
|