From Genetics to Psychosocial Functioning: Unraveling the Mediating Roles of Cognitive Reserve, Cognition, and Negative Symptoms in First-Episode Psychosis
Por:
Forte, MF, Clougher, D, Segura, AG, Mezquida, G, Sánchez-Torres, AM, Vieta, E, Garriga, M, Lobo, A, González-Pinto, AM, Diaz-Caneja, CM, Roldan, A, Martínez-Arán, A, de la Serna, E, Mané, A, Mas, S, Torrent, C, Allot, K, Bernardo, M, Amoretti, S
Publicada:
1 may 2025
Ahead of Print:
1 dic 2024
Resumen:
Background: Studies have shown associations between polygenic risk scores for educational attainment (PRSEA), cognitive reserve (CR), cognition, negative symptoms (NS), and psychosocial functioning in first-episode psychosis (FEP). However, their specific interactions remain unclear. This study aimed to investigate the mediating roles of CR, cognition, and NS in the relationship between PRSEA and psychosocial functioning one year after a FEP. Additionally, we sought to explore the impact of two NS subtypes on this relationship: diminished Expression (EXP-NS) and Motivation and Pleasure (MAP-NS). Methods: A total of 138 FEP participants, predominantly male (70%), with a mean age of 24.77 years (SD = 5.29), underwent genetic, clinical, and cognitive assessments two months after study enrollment. Functioning evaluation followed at one-year follow-up. To investigate the mediating role of CR, cognition, and NS in the relationship between PRSEA and functioning, a serial mediation model was employed. Two further mediation models were tested to explore the differential impact of EXP-NS and MAP-NS. Mediation analysis was performed using the PROCESS macro version 4.1 within SPSS version 26. Results: The serial mediation model revealed a causal chain for PRSEA > CR > cognition > NS > Functioning (beta = -3.08, 95%CI [-5.73, -0.43], p = 0.023). When differentiating by type of NS, only EXP-NS were significantly associated in the casual chain (beta = -0.17, 95% CI [-0.39, -0.01], p < 0.05). Conclusions: CR, cognition and NS -specifically EXP-NS- mediate the association between PRSEA and psychosocial functioning at one-year follow-up in FEP patients. These results highlight the potential for personalized interventions based on genetic predisposition.
Filiaciones:
Forte, MF:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS, Barcelona, Catalonia, Spain
Univ Barcelona, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Neurosci Inst, August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Clougher, D:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS, Barcelona, Catalonia, Spain
Univ Barcelona, Barcelona, Catalonia, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Mezquida, G:
Univ Barcelona, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Neurosci Inst, August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Univ Barcelona, Dept Basic Clin Practice, Barcelona, Spain
Sánchez-Torres, AM:
Univ Publ Navarra, Dept Hlth Sci, Pamplona, Spain
Navarra Inst Hlth Res IdiSNA, Pamplona, Spain
Vieta, E:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS, Barcelona, Catalonia, Spain
Univ Barcelona, Barcelona, Catalonia, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Garriga, M:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS, Barcelona, Catalonia, Spain
Univ Barcelona, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Neurosci Inst, August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Lobo, A:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Univ Zaragoza, Fac Med, Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain
González-Pinto, AM:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
OSI Araba Univ Hosp, Bioaraba Res Inst, Gasteiz, Spain
Univ Basque Country UPV EHU, Bilbao, Spain
Diaz-Caneja, CM:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Univ Complutense, Inst Psychiat & Mental Hlth, Sch Med, IiSGM,Dept Child & Adolescent Psychiat,Hosp Gen Un, Madrid, Spain
Roldan, A:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Hosp Santa Creu i St Pau, Dept Neurol, IIB ST PAU, Barcelona, Spain
Martínez-Arán, A:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS, Barcelona, Catalonia, Spain
Univ Barcelona, Barcelona, Catalonia, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
de la Serna, E:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Hosp Clin Univ, Inst Clin Neurociencies, Dept Child & Adolescent Psychiat & Psychol, Barcelona, Spain
Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, 2021SGR01319, Barcelona, Spain
Mané, A:
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Hosp del mar, Hosp Mar, Passeig Maritim 25, Barcelona, Spain
Hosp del Mar, Res Inst, Barcelona, Spain
Univ Pompeu Fabra UPF, Barcelona, Spain
Mas, S:
Univ Barcelona, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Neurosci Inst, August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona, Spain
Torrent, C:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS, Barcelona, Catalonia, Spain
Univ Barcelona, Barcelona, Catalonia, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Allot, K:
Univ Melbourne, Parkville, Vic, Australia
Ctr Youth Mental Hlth, Parkville, Australia
Bernardo, M:
Univ Barcelona, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Neurosci Inst, August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Amoretti, S:
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Neurosci Inst, August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth CIBERSAM, Madrid, Spain
Vall dHebron Res Inst VHIR, Grp Psychiat Mental Hlth & Addict, Barcelona, Spain
Green Submitted, hybrid
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