Core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition disease: OMERACT delphi survey to establish consensus
Por:
Zhang, YL, Tedeschi, SK, Abhishek, A, Hensey, O, Grossberg, D, Cai, K, Shea, B, Singh, JA, Christensen, R, Serban, T, Cipolletta, E, Parperis, K, Diaz-Torne, C, Mccarthy, GM, Becce, F, Gheita, TA, Sirotti, S, Christiansen, SN, Coronel, L, Stamp, LK, Abdel-Fattah, YH, Pascart, T, Filippou, G, Hong, LE, Fitzgerald, J, Dalbeth, N
Publicada:
1 jun 2025
Ahead of Print:
1 mar 2025
Resumen:
Objective To agree on important domains for the Outcome Measures in Rheumatology (OMERACT) core domain set for chronic and/or recurrent manifestations of calcium pyrophosphate deposition (CPPD) disease. Methods Patient research partners (PRPs) and other participants (mainly clinicians and researchers) contributed to three rounds of a consensus survey using Delphi methodology. Consensus was defined if >= 70% of both patients and other participants scored the domain as 'critically important domain to include'. In a subsequent ranking exercise, all participants were asked to select and rank up to 10 of the domains reaching consensus. Results Fifteen domains reached consensus as critically important. Within the Pathophysiological Manifestations area, these were joint pain, joint tenderness, joint swelling, acute CPP crystal arthritis flare, joint damage on imaging tests, joint calcification on imaging tests, and crystals in joint fluid. Within the Life Impact area, these were overall function, ability to complete daily tasks, ability to work, health related quality of life, patient global assessment response to treatment, patient global assessment of disease activity, physician global assessment of disease activity, and patient satisfaction with treatment. No domains within the Societal/Resource Use area reached consensus as critically important. In the ranking exercise, joint pain, joint tenderness, joint swelling, acute CPP crystal arthritis flare and overall function were most highly ranked. Conclusion This work has identified potential domains for the OMERACT core domain set for chronic and/or recurrent manifestations of CPPD disease. There was strong support for joint pain, joint tenderness, joint swelling, acute CPP crystal arthritis flare, overall function, and global assessments of disease activity as core domains.
Filiaciones:
Zhang, YL:
Univ Auckland, Auckland, New Zealand
Tedeschi, SK:
Brigham & Womens Hosp, Boston, MA USA
Abhishek, A:
Univ Nottingham, Acad Rheumatol, Nottingham, England
Nottingham NIHR BRC, Nottingham, England
Cai, K:
Westmead Hosp, Sydney, Australia
Singh, JA:
Michale E DeBakey VA Med Ctr, Houston, TX USA
Baylor Coll Med, Houston, TX USA
Christensen, R:
Bispebjerg & Frederiksberg Hosp, Parker Inst, Sect Biostat & Evidence Based Res, Copenhagen, Denmark
Univ Southern Denmark, Odense Univ Hosp, Dept Clin Res, Res Unit Rheumatol, Odense, Denmark
Serban, T:
Osped La Colletta, SC Reumatol, Arenzano, Italy
Cipolletta, E:
Univ Nottingham, Acad Rheumatol, Nottingham, England
Nottingham NIHR BRC, Nottingham, England
Polytech Univ Marche, Dept Clin & Mol Sci, Ancona, Italy
Parperis, K:
Univ Cyprus, Med Sch, Nicosia, Cyprus
Diaz-Torne, C:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Mccarthy, GM:
Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland
Becce, F:
Lausanne Univ Hosp, Lausanne, Switzerland
Gheita, TA:
Cairo Univ, Giza, Egypt
Sirotti, S:
St Ambrogio Hosp, CCS Galeazzi, Milan, Italy
Christiansen, SN:
Copenhagen Ctr Arthrit Res, Copenhagen, Denmark
Coronel, L:
Vall dHebron Univ Hosp, Barcelona, Spain
Stamp, LK:
Univ Otago, Christchurch, Christchurch, New Zealand
Abdel-Fattah, YH:
Alexandria Univ, Alexandria, Egypt
Pascart, T:
Lille Catholic Univ, Hop St Philibert, Dept Rheumatol, Lille, France
Filippou, G:
St Ambrogio Hosp, CCS Galeazzi, Milan, Italy
Univ Milan, Dept Biomed & Clin Sci, Milan, Italy
Hong, LE:
Royal Adelaide Hosp, Adelaide, SA, Australia
Fitzgerald, J:
Univ Calif Los Angeles, Los Angeles, CA USA
Vet Affairs Med Ctr, Los Angeles, CA USA
Dalbeth, N:
Univ Auckland, Auckland, New Zealand
Green Submitted, Green Published, hybrid
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