Decreased practice effects in cognitively unimpaired amyloid betapositive individuals: a multicenter, longitudinal, cohort study
Por:
Tort-Merino, A, Pérez-Millan, A, Falgàs, N, Borrego-ecija, S, Esteller, D, Bosch, B, Castellví, M, Juncà-Parella, J, del Val-Guardiola, A, Fernández-Villullas, G, Antonell, A, Sanchez-Saudinós, MB, Rubio-Guerra, S, Zhu, NL, García-Martínez, M, Pozueta, A, Estanga, A, Ecay-Torres, M, de Luis, CL, Tainta, M, Altuna, M, Rodríguez-Rodríguez, E, Sánchez-Juan, P, Martínez-Lage, P, Lleó, A, Fortea, J, Illán-Gala, I, Balasa, M, Lladó, A, Rami, L, Sánchez-Valle, R
Publicada:
25 mar 2025
Resumen:
INTRODUCTION We aimed to determine whether cognitively unimpaired (CU) amyloid- beta-positive (A beta+) individuals display decreased practice effects on serial neuropsychological testing. METHODS We included 209 CU participants from three research centers, 157 A beta- controls and 52 A beta+ individuals. Participants underwent neuropsychological assessment at baseline and annually during a 2-year follow-up. We used linear mixed-effects models to analyze cognitive change over time between the two groups, including time from baseline, amyloid status, their interaction, age, sex, and years of education as fixed effects and the intercept and time as random effects. RESULTS The A beta+ group showed reduced practice effects in verbal learning (beta = -1.14, SE = 0.40, p = 0.0046) and memory function (beta = -0.56, SE = 0.19, p = 0.0035), as well as in language tasks (beta = -0.59, SE = 0.19, p = 0.0027). DISCUSSION Individuals with normal cognition who are in the Alzheimer's continuum show decreased practice effects over annual neuropsychological testing. Our findings could have implications for the design and interpretation of primary prevention trials. Highlights This was a multicenter study on practice effects in asymptomatic A beta+ individuals. We used LME models to analyze cognitive trajectories across multiple domains. Practice-effects reductions might be an indicator of subtle cognitive decline. Implications on clinical and research settings within the AD field are discussed.
Filiaciones:
Tort-Merino, A:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Pérez-Millan, A:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Univ Oberta Catalunya, Fac Comp Sci Multimedia & Telecommun, EHlth Ctr, Barcelona, Spain
Falgàs, N:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Borrego-ecija, S:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Esteller, D:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Bosch, B:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Castellví, M:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Juncà-Parella, J:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
del Val-Guardiola, A:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Fernández-Villullas, G:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Antonell, A:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Sanchez-Saudinós, MB:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Catalonia, Spain
Inst Biomed Res, Barcelona, Catalonia, Spain
Rubio-Guerra, S:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Catalonia, Spain
Inst Biomed Res, Barcelona, Catalonia, Spain
Zhu, NL:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Catalonia, Spain
Inst Biomed Res, Barcelona, Catalonia, Spain
García-Martínez, M:
Hosp Univ Marques Valdecilla, Inst Invest Marques Valdecilla IDIVAL, Santander, Cantabria, Spain
Pozueta, A:
Hosp Univ Marques Valdecilla, Inst Invest Marques Valdecilla IDIVAL, Santander, Cantabria, Spain
Estanga, A:
Fdn CITA Alzheimer Fundazioa, Ctr Invest & Terapias Avanzadas, Donostia San Sebastian, Basque Country, Spain
Ecay-Torres, M:
Fdn CITA Alzheimer Fundazioa, Ctr Invest & Terapias Avanzadas, Donostia San Sebastian, Basque Country, Spain
de Luis, CL:
Fdn CITA Alzheimer Fundazioa, Ctr Invest & Terapias Avanzadas, Donostia San Sebastian, Basque Country, Spain
Tainta, M:
Fdn CITA Alzheimer Fundazioa, Ctr Invest & Terapias Avanzadas, Donostia San Sebastian, Basque Country, Spain
Altuna, M:
Fdn CITA Alzheimer Fundazioa, Ctr Invest & Terapias Avanzadas, Donostia San Sebastian, Basque Country, Spain
Rodríguez-Rodríguez, E:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Univ Marques Valdecilla, Inst Invest Marques Valdecilla IDIVAL, Santander, Cantabria, Spain
Univ Cantabria, Med & Psychiat Dept, Santander, Cantabria, Spain
Sánchez-Juan, P:
Alzheimers Ctr Reina Sofia CIEN Fdn ISCIII, Madrid, Spain
Martínez-Lage, P:
Fdn CITA Alzheimer Fundazioa, Ctr Invest & Terapias Avanzadas, Donostia San Sebastian, Basque Country, Spain
Lleó, A:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Catalonia, Spain
Inst Biomed Res, Barcelona, Catalonia, Spain
Fortea, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Catalonia, Spain
Inst Biomed Res, Barcelona, Catalonia, Spain
Illán-Gala, I:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Barcelona, Catalonia, Spain
Inst Biomed Res, Barcelona, Catalonia, Spain
Balasa, M:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Lladó, A:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Rami, L:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Sánchez-Valle, R:
Univ Barcelona, Fundacio Recerca Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Hosp Clin Barcelona,Alzheimers Dis & Other Cognit, Villarroel 170, Barcelona 08036, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Green Submitted, hybrid
|