Inherited kidney disease and CAKUT are common causes of kidney failure requiring kidney replacement therapy: an ERA Registry study
Por:
Ortiz, A, Kramer, A, Ariceta, G, Arevalo, OLR, Gjerstad, AC, Santiuste, C, Trujillo-Aleman, S, Ferraro, PM, Methven, S, Santamaria, R, Naumovic, R, Resic, H, Hommel, K, Segelmark, M, Ambuehl, PM, Sorensen, SS, Parmentier, C, Vidal, E, Bakkaloglu, SA, Plumb, L, Palsson, R, Kerschbaum, J, ten Dam, MAGJ, Stel, VS, Jager, KJ, Torra, R
Publicada:
1 may 2025
Ahead of Print:
1 dic 2024
Resumen:
Background Inherited kidney diseases (IKDs) and congenital anomalies of the kidney and urinary tract (CAKUT) are causes of kidney failure requiring kidney replacement therapy (KRT) that major renal registries usually amalgamate into the primary renal disease(PRD) category 'miscellaneous' or in the glomerulonephritis or pyelonephritis categories. This makes IKDs invisible (except for polycystic kidney disease) and may negatively influence the use of genetic testing, which may identify a cause for IKDs and some CAKUT. Methods We re-examined the aetiology of KRT by composing a separate IKD and CAKUT PRD group using data from the European Renal Association (ERA) Registry. Results In 2019, IKD-CAKUT was the fourth most common cause of kidney failure among incident KRT patients, accounting for 8.9% of cases [IKD 7.4% (including 5.0% autosomal dominant polycystic kidney disease), CAKUT 1.5%], behind diabetes (23.0%), hypertension (14.4%) and glomerulonephritis (10.6%). IKD-CAKUT was the most common cause of kidney failure among patients <20 years of age (41.0% of cases), but their incidence rate was highest among those ages 45-74 years (22.5 per million age-related population). Among prevalent KRT patients, IKD-CAKUT (18.5%) and glomerulonephritis (18.7%) were the two most common causes of kidney failure overall, while IKD-CAKUT was the most common cause in women (21.6%) and in patients <45 years of age (29.1%). Conclusion IKD and CAKUT are common causes of kidney failure among KRT patients. Distinct categorization of IKD and CAKUT better characterizes the epidemiology of the causes of chronic kidney disease (CKD) and highlights the importance of genetic testing in the diagnostic workup of CKD.
Filiaciones:
Ortiz, A:
IIS Fdn Jimenez Diaz UAM, Dept Nephrol & Hypertens, Madrid, Spain
Univ Autonoma Madrid, Dept Med, Madrid, Spain
Kramer, A:
Amsterdam UMC locat Univ Amsterdam, ERA Registry, Med Informat, Amsterdam, Netherlands
Amsterdam Publ Hlth Res Inst, Qual Care, Amsterdam, Netherlands
Ariceta, G:
Hosp Universitari Vall dHebron, Serv Neonatol, Barcelona, Spain
Autonomous Univ Barcelona, Dept Pediat, Barcelona, Spain
Arevalo, OLR:
Minist Universal Hlth & Publ Hlth, Registry Renal Patients Valencian Community, Gen Directorate Publ Hlth & Addict, Valencia, Spain
Univ Politecn Valencia, Hlth & Well Being Technol Program, Valencia, Spain
Gjerstad, AC:
Oslo Univ Hosp, Div Pediat & Adolescent Med, Oslo, Norway
Santiuste, C:
IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia Renal Registry, Murcia, Spain
CIBER Epidemiol & Salud Publ, Madrid, Spain
Trujillo-Aleman, S:
Hlth Qual Assessment & Informat Syst Serv, Serv Canario Salud, Direcc Gen Programas Asistenciales, Las Palmas Gran Canaria, Spain
Ferraro, PM:
Univ Verona, Dermatol Sect, Dept Med, I-37100 Verona, Italy
Reina Sofia Univ Hosp, Nephrol Serv, Cordoba, Spain
Methven, S:
Aberdeen Royal Infirm, Dept Haematol, Med, Foresterhill Hlth Campus, Aberdeen AB25 2ZN, Scotland
Santamaria, R:
Proyecto DEEPMED, Seville, Spain
Naumovic, R:
Univ Clin Hosp Ctr Zvezdara, Clin Dept Nephrol Metab Disorders & Dialysis, Belgrade, Serbia
Univ Belgrade, Sch Med, Belgrade, Serbia
Resic, H:
Soc Nephrol & Dialysis Bosnia & Herzegovina, Sarajevo, Bosnia & Herceg
Hommel, K:
Holbaek Cent Hosp, Dept Nephrol, Holbaek, Denmark
Segelmark, M:
Lund Univ, Dept Clin Sci, Lund, Sweden
Skane Univ Hosp, Dept Endocrinol Nephrol & Rheumatol, Lund, Sweden
Ambuehl, PM:
Waid & Triemli City Hosp, Inst Nephrol, Zurich, Switzerland
Sorensen, SS:
Copenhagen Univ Hosp, Dept Neurol, Rigshosp, Copenhagen, Denmark
Parmentier, C:
Armand Trousseau Childrens Hosp, APHP, Dept Paediat Nephrol, Paris, France
Vidal, E:
Padova Univ Hosp, Dept Woman & Childs Hlth, Pediat Nephrol Unit, Padua, Italy
Bakkaloglu, SA:
Gazi Univ, Dept Pediat Nephrol, Ankara, Turkiye
Plumb, L:
UK Kidney Assoc, Bristol, England
Univ Bristol, Sch Med, Bristol, England
Palsson, R:
Landspitali Univ Hosp, Div Nephrol, Reykjavik, Iceland
Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland
Kerschbaum, J:
Med Univ Innsbruck, Dept Internal Med Nephrol & Hypertens 4, Austrian Dialysis & Transplant Registry, Innsbruck, Austria
ten Dam, MAGJ:
Nefrovisie Fdn, Utrecht, Netherlands
Canisius Wilhelmina Hosp, Dept Internal Med, Nijmegen, Netherlands
Stel, VS:
Amsterdam UMC locat Univ Amsterdam, ERA Registry, Med Informat, Amsterdam, Netherlands
Amsterdam Publ Hlth Res Inst, Qual Care, Amsterdam, Netherlands
Jager, KJ:
Amsterdam UMC locat Univ Amsterdam, ERA Registry, Med Informat, Amsterdam, Netherlands
Amsterdam Publ Hlth Res Inst, Qual Care, Amsterdam, Netherlands
Torra, R:
Univ Autonoma Barcelona, Inherited Kidney Dis Nephrol Dept, REDinREN, Inherited Kidney Dis,Fundacio Puigvert, Barcelona, Spain
Green Submitted, hybrid
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