Implantable cardioverter defibrillator use in arrhythmogenic right ventricular cardiomyopathy in North America and Europe
Por:
Carrick, RT, De Marco, C, Gasperetti, A, Bosman, LP, Gourraud, JB, Trancuccio, A, Mazzanti, A, Murray, B, Pendleton, C, Tichnell, C, Tandri, H, Zeppenfeld, K, Wilde, AAM, Davies, B, Seifer, C, Roberts, JD, Healey, JS, MacIntyre, C, Alqarawi, W, Tadros, R, Cutler, MJ, Targetti, M, Calò, L, Vitali, F, Bertini, M, Compagnucci, P, Casella, M, Dello Russo, A, Cappelletto, C, De Luca, A, Stolfo, D, Duru, F, Jensen, HK, Svensson, A, Dahlberg, P, Hasselberg, NE, Di Marco, A, Jordà, P, Arbelo, E, Weidmann, ZM, Borowiec, K, Delinière, A, Biernacka, EK, van Tintelen, JP, Platonov, PG, Olivotto, I, Saguner, AM, Haugaa, KH, Cox, M, Tondo, C, Merlo, M, Krahn, AD, te Riele, ASJM, Wu, KC, Calkins, H, James, CA, Cadrin-Tourigny, J
Publicada:
16 feb 2024
Ahead of Print:
1 ene 2024
Resumen:
Background and Aims Implantable cardioverter-defibrillators (ICDs) are critical for preventing sudden cardiac death (SCD) in arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to identify cross-continental differences in utilization of primary prevention ICDs and survival free from sustained ventricular arrhythmia (VA) in ARVC.Methods This was a retrospective analysis of ARVC patients without prior VA enrolled in clinical registries from 11 countries throughout Europe and North America. Patients were classified according to whether they received treatment in North America or Europe and were further stratified by baseline predicted VA risk into low- (<10%/5 years), intermediate- (10%-25%/5 years), and high-risk (>25%/5 years) groups. Differences in ICD implantation and survival free from sustained VA events (including appropriate ICD therapy) were assessed.Results One thousand ninety-eight patients were followed for a median of 5.1 years; 554 (50.5%) received a primary prevention ICD, and 286 (26.0%) experienced a first VA event. After adjusting for baseline risk factors, North Americans were more than three times as likely to receive ICDs {hazard ratio (HR) 3.1 [95% confidence interval (CI) 2.5, 3.8]} but had only mildly increased risk for incident sustained VA [HR 1.4 (95% CI 1.1, 1.8)]. North Americans without ICDs were at higher risk for incident sustained VA [HR 2.1 (95% CI 1.3, 3.4)] than Europeans.Conclusions North American ARVC patients were substantially more likely than Europeans to receive primary prevention ICDs across all arrhythmic risk strata. A lower rate of ICD implantation in Europe was not associated with a higher rate of VA events in those without ICDs.
Filiaciones:
Carrick, RT:
Johns Hopkins Univ, Heart & Vasc Inst, Baltimore, MD USA
De Marco, C:
Univ Montreal, Montreal Heart Inst, Cardiovasc Genet Ctr, 5000 Rue Belanger, Montreal, PQ H1T 1C8, Canada
Gasperetti, A:
Johns Hopkins Univ, Heart & Vasc Inst, Baltimore, MD USA
Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
Bosman, LP:
Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Gourraud, JB:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Ctr Hosp Univ Nantes, Dept Cardiol, Nantes, France
Trancuccio, A:
Ist Clin Sci Maugeri IRCCS, Mol Cardiol, Pavia, Italy
Mazzanti, A:
Ist Clin Sci Maugeri IRCCS, Mol Cardiol, Pavia, Italy
Murray, B:
Johns Hopkins Univ, Heart & Vasc Inst, Baltimore, MD USA
Pendleton, C:
Johns Hopkins Univ, Heart & Vasc Inst, Baltimore, MD USA
Tichnell, C:
Johns Hopkins Univ, Heart & Vasc Inst, Baltimore, MD USA
Tandri, H:
Johns Hopkins Univ, Heart & Vasc Inst, Baltimore, MD USA
Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA
Zeppenfeld, K:
Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands
Wilde, AAM:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Univ Amsterdam, Amsterdam UMC, Amsterdam Cardiovasc Sci Heart Failure & Arrhythm, Heart Ctr,Dept Cardiol, Amsterdam, Netherlands
Davies, B:
Univ British Columbia, Div Cardiol, Ctr Cardiac Innovat, Vancouver, BC, Canada
Seifer, C:
Univ Manitoba, St Boniface Hosp, Winnipeg, MB, Canada
Roberts, JD:
McMaster Univ, Populat Hlth Res Inst, Hamilton Hlth Sci, Hamilton, ON, Canada
Western Univ, Dept Med, Div Cardiol, Sect Cardiac Electrophysiol, London, ON, Canada
Healey, JS:
McMaster Univ, Populat Hlth Res Inst, Hamilton Hlth Sci, Hamilton, ON, Canada
MacIntyre, C:
Dalhousie Univ, Queen Elizabeth II Hlth Sci Ctr, Halifax, NS, Canada
Mayo Clin, Dept Med, Rochester, MN USA
Alqarawi, W:
King Saudi Univ, Coll Med, Dept Cardiac Sci, Riyadh, Saudi Arabia
Univ Ottawa, Univ Ottawa Heart Inst, Div Cardiol, Ottawa, ON, Canada
Tadros, R:
Univ Montreal, Montreal Heart Inst, Cardiovasc Genet Ctr, 5000 Rue Belanger, Montreal, PQ H1T 1C8, Canada
Cutler, MJ:
Intermt Med Ctr, Intermt Med Ctr Heart Inst, Murray, UT USA
Targetti, M:
Careggi Hosp, Cardiomyopathy Unit, Florence, Italy
Meyer Childrens Hosp IRCCS, Florence, Italy
Calò, L:
Policlin Casilino, Div Cardiol, Rome, Italy
Vitali, F:
Univ Ferrara, St Anna Univ Hosp, Cardiol Unit, Ferrara, Italy
Bertini, M:
Univ Ferrara, St Anna Univ Hosp, Cardiol Unit, Ferrara, Italy
Compagnucci, P:
Univ Hosp Osped Riuniti, Cardiol & Arrhythmol Clin, Ancona, Italy
Casella, M:
Univ Hosp Osped Riuniti, Cardiol & Arrhythmol Clin, Ancona, Italy
Dello Russo, A:
Univ Hosp Osped Riuniti, Cardiol & Arrhythmol Clin, Ancona, Italy
Cappelletto, C:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Azienda Sanit Univ Giuliano Isontina, Cardiothoracovasc Dept, Div Cardiol, Trieste, Italy
Univ Trieste, Trieste, Italy
Karolinska Inst, Dept Med, Div Cardiol, Stockholm, Sweden
De Luca, A:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Azienda Sanit Univ Giuliano Isontina, Cardiothoracovasc Dept, Div Cardiol, Trieste, Italy
Univ Trieste, Trieste, Italy
Stolfo, D:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Azienda Sanit Univ Giuliano Isontina, Cardiothoracovasc Dept, Div Cardiol, Trieste, Italy
Univ Trieste, Trieste, Italy
Karolinska Inst, Dept Med, Div Cardiol, Stockholm, Sweden
Duru, F:
Univ Heart Ctr Zurich, Dept Cardiol, Zurich, Switzerland
Jensen, HK:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Aarhus Univ Hosp, Dept Cardiol, Aarhus N, Denmark
Aarhus Univ, Dept Clin Med, Hlth, Aarhus N, Denmark
Svensson, A:
Linkoping Univ Hosp, Dept Cardiol, Linkoping, Sweden
Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden
Dahlberg, P:
Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden
Hasselberg, NE:
Univ Oslo, Oslo Univ Hosp, Rikshosp, ProCardio Ctr Innovat,Dept Cardiol, Oslo, Norway
Di Marco, A:
Hosp Univ Bellvitge, Dept Cardiol, Arrhythmia Unit, Barcelona, Spain
Bellvitge Biomed Res Inst IDIBELL, BioHeartCardiovasc Dis Res Grp, Barcelona, Spain
Jordà, P:
Univ Montreal, Montreal Heart Inst, Cardiovasc Genet Ctr, 5000 Rue Belanger, Montreal, PQ H1T 1C8, Canada
Univ Barcelona, Hosp Clin, Dept Cardiol, Arrhythmia Sect, Barcelona, Spain
Arbelo, E:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Univ Barcelona, Hosp Clin, Dept Cardiol, Arrhythmia Sect, Barcelona, Spain
Inst Invest August Pi & Sunyer IDIBAPS, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid, Spain
Weidmann, ZM:
Hosp Univ St Pau, Dept Cardiol, Arrhythmia Unit, Barcelona, Spain
Borowiec, K:
Cardinal Wyszynski Natl Inst Cardiol, Dept Congenital Heart Dis, Warsaw, Poland
Cardinal Wyszynski Natl Inst Cardiol, Outpatient Dept Genet Arrhythmias, Warsaw, Poland
Delinière, A:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Hosp Civils Lyon, Louis Pradel Cardiovasc Hosp, Natl Reference Ctr Inherited Arrhythmias Lyon, Dept Cardiol, Lyon, France
Claude Bernard Lyon 1 Univ, Univ Lyon, Inst NeuroMyoGene, MeLiS,CNRS,UMR 5284,INSERM,U1314, Lyon, France
Biernacka, EK:
Cardinal Wyszynski Natl Inst Cardiol, Dept Congenital Heart Dis, Warsaw, Poland
Cardinal Wyszynski Natl Inst Cardiol, Outpatient Dept Genet Arrhythmias, Warsaw, Poland
van Tintelen, JP:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Univ Utrecht, Univ Med Ctr Utrecht, Dept Genet, Utrecht, Netherlands
Platonov, PG:
Lund Univ, Dept Cardiol, Clin Sci, Lund, Sweden
Olivotto, I:
Careggi Hosp, Cardiomyopathy Unit, Florence, Italy
Meyer Childrens Hosp IRCCS, Florence, Italy
Saguner, AM:
Univ Heart Ctr Zurich, Dept Cardiol, Zurich, Switzerland
Haugaa, KH:
Univ Oslo, Oslo Univ Hosp, Rikshosp, ProCardio Ctr Innovat,Dept Cardiol, Oslo, Norway
Cox, M:
Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
Tondo, C:
Univ Milan, IRCCS, Ctr Cardiol Monzino, Dept Clin Electrophysiol & Cardiac Pacing, Milan, Italy
Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy
Merlo, M:
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Azienda Sanit Univ Giuliano Isontina, Cardiothoracovasc Dept, Div Cardiol, Trieste, Italy
Univ Trieste, Trieste, Italy
Krahn, AD:
Univ British Columbia, Div Cardiol, Ctr Cardiac Innovat, Vancouver, BC, Canada
te Riele, ASJM:
Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
European Reference Network Rare Low Prevalence &, Amsterdam, Netherlands
Wu, KC:
Johns Hopkins Univ, Heart & Vasc Inst, Baltimore, MD USA
Calkins, H:
Johns Hopkins Univ, Heart & Vasc Inst, Baltimore, MD USA
James, CA:
Johns Hopkins Univ, Heart & Vasc Inst, Baltimore, MD USA
Cadrin-Tourigny, J:
Univ Montreal, Montreal Heart Inst, Cardiovasc Genet Ctr, 5000 Rue Belanger, Montreal, PQ H1T 1C8, Canada
Green Published, hybrid
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