Down Syndrome Biobank Consortium: A perspective
Por:
Aldecoa, I, Barroeta, I, Carroll, SL, Fortea, J, Gilmore, A, Ginsberg, SD, Guzman, SJ, Hamlett, ED, Head, E, Perez, SE, Potter, H, Molina-Porcel, L, Raha-Chowdhury, R, Wisniewski, T, Yong, WH, Zaman, S, Ghosh, S, Mufson, EJ, Granholm, AC
Publicada:
1 mar 2024
Ahead of Print:
1 ene 2024
Resumen:
Individuals with Down syndrome (DS) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early-onset Alzheimer's disease (AD)-type dementia by early midlife. Despite ongoing clinical trials to treat late-onset AD, individuals with DS are often excluded. Furthermore, timely diagnosis or management is often not available. Of the genetic causes of AD, people with DS represent the largest cohort. Currently, there is a knowledge gap regarding the underlying neurobiological mechanisms of DS-related AD (DS-AD), partly due to limited access to well-characterized brain tissue and biomaterials for research. To address this challenge, we created an international consortium of brain banks focused on collecting and disseminating brain tissue from persons with DS throughout their lifespan, named the Down Syndrome Biobank Consortium (DSBC) consisting of 11 biobanking sites located in Europe, India, and the USA. This perspective describes the DSBC harmonized protocols and tissue dissemination goals.
Filiaciones:
Aldecoa, I:
Univ Barcelona, Hosp Clin Barcelona, Pathol Dept, Barcelona, Spain
Hosp Clin Barcelona, Neurol Tissue Bank Biobank, FCRB, IDIBAPS, Barcelona, Spain
Barroeta, I:
Hosp St Creu i St Pau, Neurol Dept, Neurol, Barcelona, Spain
Carroll, SL:
Med Univ South Carolina, Dept Pathol & Lab Med, Charleston, SC USA
Fortea, J:
Hosp St Creu i St Pau, Neurol Dept, Neurol, Barcelona, Spain
Gilmore, A:
Univ Colorado Denver, Neurosurg, Anschutz Med Campus, Aurora, CO USA
Ginsberg, SD:
Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY USA
NYU, Dept Psychiat Neurosci & Physiol, Grossman Sch Med, New York, NY USA
NYU, NYU Neurosci Inst, Grossman Sch Med, New York, NY USA
Guzman, SJ:
Univ Colorado, Dept Pathol, Anschutz Med Campus, Aurora, CO USA
Hamlett, ED:
Med Univ South Carolina, Dept Pathol & Lab Med, Charleston, SC USA
Head, E:
Univ Calif Irvine, UCI Sch Med Med D440 Sciences1, Dept Pathol & Lab Med, Irvine, CA USA
Perez, SE:
Barrow Neurol Inst, Translat Neurosci & Neurol, Phoenix, AZ USA
Potter, H:
Univ Colorado Denver, Neurol, Anschutz Med Campus, Aurora, CO USA
Molina-Porcel, L:
Univ Barcelona, Hosp Clin Barcelona, Pathol Dept, Barcelona, Spain
Univ Barcelona, Hosp Clin, Neurol Serv, Alzheimers Dis & Other Cognit Disorders Unit,IDIBA, Barcelona, Spain
Raha-Chowdhury, R:
Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge, England
Wisniewski, T:
NYU, Ctr Cognit Neurol, Grossman Sch Med, Dept Neurol, New York, NY USA
NYU, Ctr Cognit Neurol, Dept Pathol, Grossman Sch Med, New York, NY USA
NYU, Ctr Cognit Neurol, Dept Psychiat, Grossman Sch Med, New York, NY USA
Yong, WH:
Univ Calif Irvine, UCI Sch Med Med D440 Sciences1, Dept Pathol & Lab Med, Irvine, CA USA
Zaman, S:
Univ Cambridge, Dept Psychiat, Cambridge Intellectual & Dev Disabil Res Grp, Cambridge, England
Ghosh, S:
Dept Zool, Cytogenet & Genom Res Unit, Kolkata, India
Mufson, EJ:
Barrow Neurol Inst, Translat Neurosci & Neurol, Phoenix, AZ USA
Granholm, AC:
Univ Colorado Denver, Neurosurg, Anschutz Med Campus, Aurora, CO USA
Univ Colorado, Dept Neurosurg, Anschutz Med Campus,Res Complex 2,Room P15-5112,12, Aurora, CO 80045 USA
Green Published, hybrid
|