2-Hydroxyethyl methacrylate (2-HEMA) sensitization, a global epidemic at its peak in Spain?
Por:
Gatica-Ortega, ME, Pastor-Nieto, MA, Giménez-Arnau, AM, Mercader-García, P, Sanz-Sánchez, T, Carrascosa-Carrillo, JM, Córdoba-Guijarro, S, Sánchez-Pérez, J, Silvestre, JF, Frutos, FJOD, Tous-Romero, F, Fernández-Redondo, V, Serra-Baldrich, E, Ruíz-González, I, Pérez, RG, Miquel-Miquel, J, Guillén, PSP, Hervella-García, M, Heras-Mendaza, F, Gómez-de-la-Fuente, E, Zaragoza-Ninet, V, Gilo, AS, Rodríguez-Serna, M, Melé-Ninot, G, Descalzo, MA, de-Vega, M, García-Doval, I, Borrego, L
Publicada:
1 may 2024
Ahead of Print:
1 feb 2024
Resumen:
Background: A global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products. Objectives: To evaluate the frequency of sensitization to 2-hydroxyethyl methacrylate (2-HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates. Methods: From January 2019 to December 2022, 2-HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres. ResultsSix thousand one hundred thirty-four patients were consecutively patch tested with 2-HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable 'occupational' was found to be significantly associated with a higher risk for relevant positive reactions to 2-HEMA (OR: 10.9; 95% CI: 8.1-14.9). Conclusion: (Meth)acrylate sensitization is a prevalent health issue in Spain. 2-HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means.
Filiaciones:
Gatica-Ortega, ME:
Complejo Hosp Univ Toledo, Dermatol Dept, Toledo, Spain
Univ Castilla La Mancha, Escuela Int Doctorado, Toledo, Spain
Acad Espanola Dermatol & Venereol, Unidad Invest, Ferraz 100,1 Izda, Madrid 28008, Spain
Pastor-Nieto, MA:
Univ Castilla La Mancha, Escuela Int Doctorado, Toledo, Spain
Hosp Univ Guadalajara, Dermatol Dept, Guadalajara, Spain
Hosp Univ Fdn Jimenez Diaz, Dermatol Dept, Madrid, Spain
Univ Alcala, Fac Med & Hlth Sci, Dept Med & Med Specialties, Alcala De Henares, Spain
Giménez-Arnau, AM:
Univ Pompeu Fabra, Hosp Mar Res Inst, Dept Dermatol, Barcelona, Spain
Mercader-García, P:
Hosp Gen Univ Jose Ma Morales Meseguer, Dept Dermatol, Murcia, Spain
Sanz-Sánchez, T:
Hosp Univ Infanta Sofia, Dermatol Dept, Madrid, Spain
Carrascosa-Carrillo, JM:
UAB, Dermatol Dept, IGTP, Hosp Univ Germans Trias & Pujol, Barcelona, Spain
Córdoba-Guijarro, S:
Hosp Univ Fuenlabrada, Dermatol Dept, Madrid, Spain
Sánchez-Pérez, J:
Hosp Univ La Princesa, Dermatol Dept, Madrid, Spain
Silvestre, JF:
Hosp Gen Univ Dr Balmis, Dept Dermatol, ISABIAL, Alicante, Spain
Frutos, FJOD:
Hosp Univ 12 Octubre, Dermatol Dept, Madrid, Spain
Tous-Romero, F:
Hosp Univ 12 Octubre, Dermatol Dept, Madrid, Spain
Fernández-Redondo, V:
Complejo Hosp Univ, Dermatol Dept, Santiago De Compostela, Spain
Serra-Baldrich, E:
Hosp La Santa Creu i St Pau, Dermatol Dept, Barcelona, Spain
Ruíz-González, I:
Complejo Asistencial Univ Leon, Dermatol Dept, Leon, Spain
Pérez, RG:
Hosp Univ Araba, Dermatol Dept, Vitoria, Spain
Miquel-Miquel, J:
Hosp Arnau Vilanova, Dermatol Dept, Valencia, Spain
Guillén, PSP:
Hosp Univ Virgen Arrixaca, Dermatol Dept, Murcia, Spain
Hervella-García, M:
Complejo Hosp Navarra, Dermatol Dept, Pamplona, Spain
Heras-Mendaza, F:
Hosp Univ Fdn Jimenez Diaz, Dermatol Dept, Madrid, Spain
Gómez-de-la-Fuente, E:
Hosp Univ Fdn Alcorcon, Dept Dermatol, Madrid, Spain
Zaragoza-Ninet, V:
Hosp Gen Univ Valencia, Dept Dermatol, Valencia, Spain
Gilo, AS:
Hosp Univ Rey Juan Carlos, Dept Dermatol, Madrid, Spain
Rodríguez-Serna, M:
Hosp Univ La Fe, Dermatol Dept, Valencia, Spain
Melé-Ninot, G:
Hosp Univ Sagrat Cor, Dept Dermatol, Grp Quironsalud, Barcelona, Spain
Descalzo, MA:
Spanish Acad Dermatol, Unidad Invest Fdn Piel Sana AEDV, Madrid, Spain
de-Vega, M:
Spanish Acad Dermatol, Unidad Invest Fdn Piel Sana AEDV, Madrid, Spain
García-Doval, I:
Spanish Acad Dermatol, Unidad Invest Fdn Piel Sana AEDV, Madrid, Spain
Borrego, L:
Univ Las Palmas Gran Canaria, Dept Dermatol, Hosp Univ Insular de Gran Canaria, Las Palmas Gran Canaria, Spain
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