A re-assessment of the value of markers of corticosteroid contact allergy in the Spanish baseline series: Clobetasol propionate in the spotlight
Por:
Mercader-García, P, Silvestre, JF, Navarro-Triviño, FJ, Giménez-Arnau, AM, Pastor-Nieto, MA, Cordoba-Guijarro, S, Melé-Ninot, G, Tous-Romero, F, González-Pérez, R, Ruiz-González, I, Sánchez-Pérez, J, Gática-Ortega, ME, Sánchez-Pedreño, P, Miquel-Miquel, J, Ortiz-Frutos, J, Carrascosa, JM, Serra-Baldrich, E, Sanz-Sanchez, T, Soria-Aledo, V, Carrillo, A, Borrego, L
Publicada:
1 sep 2024
Ahead of Print:
1 jul 2024
Resumen:
BackgroundBudesonide and tixocortol pivalate as markers of contact allergy to corticosteroids have been questioned, as they are not able to detect a significant percentage of allergic patients.ObjectivesTo investigate the potential role of clobetasol propionate in enhancing corticosteroid sensitisation detection.MethodsBetween January 2022 and December 2023, patients who attended centres involved in the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy were tested with an extended baseline series that included budesonide, tixocortol pivalate, clobetasol propionate 0.1% in ethanol and 1% in petrolatum.ResultsA total of 4338 patients were tested. Twenty-four patients were allergic to budesonide (0.55%, 95% CI: 0.37-0.82); nine patients were allergic to tixocortol pivalate (0.21%, 95% CI: 0.11-0.39); and 23 patients were allergic to clobetasol (0.53%, 95% CI: 0.35-0.79). Only four of those patients allergic to clobetasol were detected by budesonide and one by tixocortol pivalate. No significant differences in the number of positive tests were found between clobetasol in petrolatum or ethanol.ConclusionsIn Spain budesonide remains the main corticosteroid allergy marker whereas the role of tixocortol pivalate is questionable. The addition of clobetasol propionate to the Spanish baseline series would improve the ability to detect patients allergic to corticosteroids.
Clobetasol propionate has similar prevalence of positive patch test than that of budesonide in Spain. Most of the allergic patients to clobetasol propionate are not detected by budesonide nor tixocortol pivalate. image
Filiaciones:
Mercader-García, P:
Univ Murcia, Hosp Gen Univ Morales Meseguer, Murcia, Spain
Silvestre, JF:
Hosp Gen Univ Dr Balmis, Dermatol Dept, Alicante, Spain
Navarro-Triviño, FJ:
Hosp Univ San Cecilio, Dermatol Dept, Granada, Spain
Giménez-Arnau, AM:
Hosp Mar IMIM, Dermatol Dept, Barcelona, Spain
Pastor-Nieto, MA:
Fdn Jimenez Diaz, Dept Pathol, Madrid, Spain
Cordoba-Guijarro, S:
Hosp Univ Fuenlabrada, Dermatol Dept, Madrid, Spain
Melé-Ninot, G:
Hosp Univ Sagrat Cor, Dermatol Dept, Barcelona, Spain
Tous-Romero, F:
Hosp Gen Univ 12 Octubre, Dermatol Dept, Madrid, Spain
González-Pérez, R:
Hosp Univ Araba, Dermatol Dept, Vitoria, Spain
Ruiz-González, I:
Complejo Asistencial Univ Leon, Dermatol Dept, Leon, Spain
Sánchez-Pérez, J:
Hosp Univ Princesa, Dermatol Dept, Madrid, Spain
Gática-Ortega, ME:
Complejo Hosp Univ Toledo, Dermatol Dept, Toledo, Spain
Sánchez-Pedreño, P:
Hosp Clin Univ Virgen Arrixaca, Dermatol Dept, Murcia, Spain
Miquel-Miquel, J:
Hosp Arnau Vilanova, Dermatol Dept, Valencia, Spain
Ortiz-Frutos, J:
Hosp Gen Univ 12 Octubre, Dermatol Dept, Madrid, Spain
Carrascosa, JM:
Hosp Univ German Trias i Pujol, Dermatol Dept, Barcelona, Spain
Serra-Baldrich, E:
Hosp Univ Santa Creu i St Pau, Cardiol Dept, Barcelona, Spain
Sanz-Sanchez, T:
Hosp Univ Infanta Sofia, Dermatol Dept, Madrid, Spain
Soria-Aledo, V:
Univ Murcia, Hosp Gen Univ Morales Meseguer, Murcia, Spain
Carrillo, A:
Univ Murcia, Hosp Gen Univ Morales Meseguer, Murcia, Spain
Borrego, L:
Univ Las Palmas Gran Canaria, Complejo Hosp Univ Insular Materno Infantil, Las Palmas Gran Canaria, Spain
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