Low-Density Lipoprotein Subfraction Phenotype Is Associated with Epicardial Adipose Tissue Volume in Type 2 Diabetes
Por:
Rives, J, Gil-Millan, P, Viladés, D, García-Osuna, A, Genua, I, Miñambres, I, Grau-Agramunt, M, Gich, I, Puig, N, Benitez, S, Julve, J, Pérez, A, Sánchez-Quesada, JL
Publicada:
1 feb 2025
Resumen:
Background: Increased epicardial adipose tissue (EAT) volume is a common feature in type 2 diabetes (T2DM) which is directly associated with heart failure and advanced atherosclerosis. We aimed to evaluate lipoprotein-related biomarkers of EAT volume in T2DM patients before and after glycemic control. Methods: This study included 36 T2DM patients before and after optimization of glycemic control and on 14 healthy controls (HCs). EAT volume was measured using computed tomography imaging indexed to the body surface area (iEAT). Biochemical and lipid profiles were determined using commercial methods. Lipoproteins were isolated by ultracentrifugation, and variables of lipoprotein function were assessed. Multivariable regression analysis was used to find variables independently associated with iEAT. Results: iEAT was higher in T2DM than in controls and decreased with glycemic optimization. HDLs from T2DM had less apoA-I and cholesterol and more apoC-III and triglycerides. LDLs from T2DM had more triglycerides and apoB and smaller sizes than those from HCs. Significant correlations were found between iEAT and age, BMI, HbA1c, GGT, VLDLc, triglycerides, LDL size, apoA-I in HDL, and apoC-III in HDL. In the multivariable regression analysis, age, LDL size, and GGT associations remained statistically significant, and predicted 50% of the variability in EAT volume. ROC analysis using these variables showed an AUC of 0.835. Conclusions: Qualitative characteristics of lipoproteins were altered in T2DM. Multivariable analysis showed that LDL size and GGT plasma levels were independently associated with iEAT volume, suggesting that these variables might be useful biomarkers for stratifying T2DM patients with increased EAT volume.
Filiaciones:
Rives, J:
Inst Recerca St Pau Irsant Pau, Cardiovasc Biochem, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Biochem & Mol Biol, Barcelona 08193, Spain
Gil-Millan, P:
Hosp Santa Creu & Sant Pau, Endocrinol Dept, Barcelona 08041, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona 08193, Spain
Viladés, D:
Hosp Santa Creu & Sant Pau, Cardiol Dept, Barcelona 08041, Spain
CIBER Cardiovasc Dis CIBERCV, Madrid, Spain
García-Osuna, A:
Inst Recerca St Pau Irsant Pau, Cardiovasc Biochem, Barcelona 08041, Spain
Genua, I:
Hosp Santa Creu & Sant Pau, Endocrinol Dept, Barcelona 08041, Spain
Miñambres, I:
Hosp Santa Creu & Sant Pau, Endocrinol Dept, Barcelona 08041, Spain
CIBER Diabet & Metab Dis CIBERDEM, Madrid, Spain
Grau-Agramunt, M:
Inst Recerca St Pau Irsant Pau, Cardiovasc Biochem, Barcelona 08041, Spain
Gich, I:
Hosp Santa Creu & Sant Pau, Epidemiol Dept, Barcelona 08041, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
Puig, N:
Inst Recerca St Pau Irsant Pau, Cardiovasc Biochem, Barcelona 08041, Spain
Benitez, S:
Inst Recerca St Pau Irsant Pau, Cardiovasc Biochem, Barcelona 08041, Spain
CIBER Diabet & Metab Dis CIBERDEM, Madrid, Spain
Julve, J:
Hosp Santa Creu & Sant Pau, Endocrinol Dept, Barcelona 08041, Spain
CIBER Diabet & Metab Dis CIBERDEM, Madrid, Spain
Pérez, A:
Hosp Santa Creu & Sant Pau, Endocrinol Dept, Barcelona 08041, Spain
CIBER Diabet & Metab Dis CIBERDEM, Madrid, Spain
Sánchez-Quesada, JL:
Inst Recerca St Pau Irsant Pau, Cardiovasc Biochem, Barcelona 08041, Spain
CIBER Diabet & Metab Dis CIBERDEM, Madrid, Spain
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