Genetic architecture of neurodegenerative dementias
Por:
Clarimon, J, Moreno-Grau, S, Cervera-Carles, L, Dols-Icardo, O, Sanchez-Juan, P, Ruiz, A
Publicada:
15 may 2020
Resumen:
Molecular genetics has been an invaluable tool to help understand the molecular basis of neurodegenerative dementias. In this review, we provide an overview of the genetic architecture underlying some of the most prevalent causes of dementia, including Alzheimer's dementia, frontotemporal lobar degeneration, Lewy body dementia, and prion diseases. We also discuss the complexity of the human genome and how the novel technologies have revolutionized and accelerated the way we screen the variety of our DNA. Finally, we also provide some examples about how this genetic knowledge is being transferred into the clinic through personalized medicine.
This article is part of the special issue entitled 'The Quest for Disease-Modifying Therapies for Neurodegenerative Disorders'.
Filiaciones:
Clarimon, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Genet Neurodegenerat Disorders Unit, Barcelona, Spain
Ctr Networked Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Moreno-Grau, S:
Ctr Networked Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
UIC, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain
UIC, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
Cervera-Carles, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Genet Neurodegenerat Disorders Unit, Barcelona, Spain
Ctr Networked Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Dols-Icardo, O:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, St Pau Biomed Res Inst, Genet Neurodegenerat Disorders Unit, Barcelona, Spain
Ctr Networked Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Sanchez-Juan, P:
Ctr Networked Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Cantabria, Univ Hosp Marques Valdecilla, Neurol Serv, Santander, Spain
IDIVAL, Santander, Spain
Ruiz, A:
Ctr Networked Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
UIC, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain
UIC, Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain
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