Intradialytic Parenteral Nutrition in Patients on Hemodialysis: A Multicenter Retrospective Study
Por:
Arias-Guillén, M, González, JC, Betancourt, L, Coll, E, Collado, S, Romano-Andrioni, B, Lupiañez-Barbero, A, Garro, J, Duarte, V, Soler-Majoral, J, Calabia, J
Publicada:
1 dic 2024
Resumen:
Background and Objective: To evaluate the effectiveness and safety of intradialytic parenteral nutrition (IDPN) on different nutritional outcomes. Methods: This was a retrospective analysis for a "routinely collected data bank" in a multicenter cohort, conducted on consecutive malnourished or at-risk of malnutrition patients with chronic kidney disease on hemodialysis who underwent IDPN with a three-in-one parenteral nutrition formula for a period >= 2 weeks. The primary endpoint was the mean change in the malnutrition inflammation score (MIS) score between baseline and the last follow-up visit on IDPN. Results: Fifty-six patients were included. The mean age was 72.4 +/- 12.0 years, and 24 (42.9%) were women. In the overall study sample, MIS significantly decreased from 16.4 (95%CI: 15.3-17.65) at baseline to 14.3 (95%CI: 12.8-15.8) at the last follow-up visit on IDPN (p = 0.0019). Fifteen (26.8%) patients achieved a MIS reduction >= 5 points after IDPN. As compared to baseline, IDPN significantly reduced the proportion of patients with protein-energy wasting (PEW) (89.3% versus 66.1%, respectively, p = 0.0023). Regarding analytical parameters, serum albumin (p = 0.0003) and total proteins (p = 0.0024) significantly increased after IDPN administration. Throughout the study's follow-up period, 45 (80.4%) patients reported experiencing some type of adverse event. Conclusions: IDPN was associated with a significant improvement in the nutritional profile. Notably, our research found that the administration of IDPN over a duration > 3 months significantly improved the nutritional status of patients evaluated by the MIS test.
Filiaciones:
Arias-Guillén, M:
Hosp Clin Barcelona, Dept Nephrol & Renal Transplantat, E-08036 Barcelona, Spain
González, JC:
Hosp Mollet, Dept Oncol, Barcelona 08100, Spain
Betancourt, L:
Corporacio Sanitaria Parc Tauli, Nephrol Dept, Barcelona 08208, Spain
Coll, E:
Fundacio Puigvert, Nephrol Dept, Barcelona 08025, Spain
Collado, S:
Hosp Mar Parc Salut Mar, Dept Hematol, Barcelona 08003, Spain
Romano-Andrioni, B:
Hosp Clin Barcelona, Nutr & Dietet Unit, Barcelona 08036, Spain
Lupiañez-Barbero, A:
Diaverum Renal Serv, Nutr, Barcelona 08024, Catalonia, Spain
Garro, J:
Hosp Univ Joan XXIII, Nephrol Dept, Tarragona 43005, Spain
Duarte, V:
Hosp Terrassa, Nephrol Dept, Terrassa 08227, Spain
Soler-Majoral, J:
Hosp Germans Trias I Pujol, Nephrol Dept, Barcelona 08916, Spain
Calabia, J:
Hosp Univ Dr J Trueta, Nephrol Dept, Girona 17007, Spain
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