Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia
Por:
Manzoni, C, Kia, DA, Ferrari, R, Leonenko, G, Costa, B, Saba, V, Jabbari, E, Tan, MMX, Albani, D, Alvarez, V, Alvarez, I, Andreassen, OA, Angiolillo, A, Arighi, A, Baker, M, Benussi, L, Bessi, V, Binetti, G, Blackburn, DJ, Boada, M, Boeve, BF, Borrego-Ecija, S, Borroni, B, Bråthen, G, Brooks, WS, Bruni, AC, Caroppo, P, Bandres-Ciga, S, Clarimon, J, Colao, R, Cruchaga, C, Danek, A, de Boer, SCM, de Rojas, I, di Costanzo, A, Dickson, DW, Diehl-Schmid, J, Dobson-Stone, C, Dols-Icardo, O, Donizetti, A, Dopper, E, Durante, E, Ferrari, C, Forloni, G, Frangipane, F, Fratiglioni, L, Kramberger, MG, Galimberti, D, Gallucci, M, García-González, P, Ghidoni, R, Giaccone, G, Graff, C, Graff-Radford, NR, Grafman, J, Halliday, GM, Hernandez, DG, Hjermind, LE, Hodges, JR, Holloway, G, Huey, ED, Illán-Gala, I, Josephs, KA, Knopman, DS, Kristiansen, M, Kwok, JB, Leber, I, Leonard, HL, Libri, I, Lleo, A, Mackenzie, IR, Madhan, GK, Maletta, R, Marquié, M, Maver, A, Menendez-Gonzalez, M, Milan, G, Miller, BL, Morris, CM, Morris, HR, Nacmias, B, Newton, J, Nielsen, JE, Nilsson, C, Novelli, V, Padovani, A, Pal, S, Pasquier, F, Pastor, P, Perneczky, R, Peterlin, B, Petersen, RC, Piguet, O, Pijnenburg, YAL, Puca, AA, Rademakers, R, Rainero, I, Reus, LM, Richardson, AMT, Riemenschneider, M, Rogaeva, E, Rogelj, B, Rollinson, S, Rosen, H, Rossi, G, Rowe, JB, Rubino, E, Ruiz, A, Salvi, E, Sanchez-Valle, R, Sando, SB, Santillo, AF, Saxon, JA, Schlachetzki, JCM, Scholz, SW, Seelaar, H, Seeley, WW, Serpente, M, Sorbi, S, Sordon, S, St George-Hyslop, P, Thompson, JC, Van Broeckhoven, C, Van Deerlin, VM, Van der Lee, SJ, Van Swieten, J, Tagliavini, F, van der Zee, J, Veronesi, A, Vitale, E, Waldo, ML, Yokoyama, JS, Nalls, MA, Momeni, P, Singleton, AB, Hardy, J, Escott-Price, V
Publicada:
11 jul 2024
Ahead of Print:
1 jul 2024
Resumen:
Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found a cluster of variants at the MAPT (rs199443; p = 2.5 3 10(-12), OR = 1.27) and APOE (rs6857; p = 1.31 3 10(-12), OR = 1.27) loci and a candidate locus on chromosome 3 (rs1009966; p = 2.41 3 10(-8), OR = 1.16) in the intergenic region between RPSA and MOBP, contributing to increased risk for sFTD through effects on expression and/or splicing in brain cortex of functionally relevant in-cis genes at the MAPT and RPSA-MOBP loci. The association with the MAPT (H1c clade) and RPSA-MOBP loci may suggest common genetic pleiotropy across FTD and progressive supranuclear palsy (PSP) (MAPT and RPSA-MOBP loci) and across FTD, AD, Parkinson disease (PD), and cortico-basal degeneration (CBD) (MAPT locus). Our data also suggest population specificity of the risk signals, with MAPT and APOE loci associations mainly driven by Central/Nordic and Mediterranean Europeans, respectively. This study lays the foundations for future work aimed at further characterizing population-specific features of potential FTD-discriminant APOE haplotype(s) and the functional involvement and contribution of the MAPT H1c haplotype and RPSA-MOBP loci to pathogenesis of sporadic forms of FTD in brain cortex.
Filiaciones:
Manzoni, C:
UCL Sch Pharm, London, England
Kia, DA:
UCL Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, London, England
Ferrari, R:
UCL Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, London, England
Leonenko, G:
Cardiff Univ, UK Dementia Res Inst, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales
Costa, B:
UCL Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, London, England
Saba, V:
Univ Pavia, Dept Brain & Behav Sci, Med & Genom Stat Unit, Pavia, Italy
Jabbari, E:
UCL Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, London, England
Tan, MMX:
UCL Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, London, England
Oslo Univ Hosp, Dept Neurol, Oslo, Norway
Albani, D:
Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy
Alvarez, V:
Hosp Univ Cent Asturias, Oviedo, Spain
Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Alvarez, I:
Hosp Univ Mutua Terrassa, Dept Neurol, Memory Disorders Unit, Barcelona, Spain
Fundacio Docencia Recerca MutuaTerrssa, Barcelona, Spain
Andreassen, OA:
Univ Oslo, Inst Clin Med, NORMENT Ctr, Oslo, Norway
Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway
Angiolillo, A:
Univ Molise, Dept Med & Hlth Sci V Tiberio, Ctr Res & Training Med Aging, Campobasso, Italy
Arighi, A:
Fdn IRCCS CaGranda, Osped Maggiore Policlin, Milan, Italy
Baker, M:
Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Benussi, L:
IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Bessi, V:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
Binetti, G:
IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, MAC Memory Clin, Brescia, Italy
Blackburn, DJ:
Univ Sheffield, Sheffield, S Yorkshire, England
Boada, M:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Boeve, BF:
Mayo Clin, Dept Neurol, Rochester, MN USA
Borrego-Ecija, S:
Fundacio Clin Barcelona IDIBAPS, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol, Hosp Clin Barcelona, Barcelona, Spain
Borroni, B:
Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy
Bråthen, G:
Univ Hosp Trondheim, Dept Neurol & Clin Neurophysiol, Trondheim, Norway
Norwegian Univ Sci & Technol, Dept Neuromed & Movement Sci, Fac Med & Hlth Sci, Trondheim, Norway
Brooks, WS:
Univ New South Wales, UNSW Med & Hlth, Neurosci Res Australia, Sydney, NSW, Australia
Univ New South Wales, UNSW Med & Hlth, Randwick Clin Campus, Sydney, NSW, Australia
Bruni, AC:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Caroppo, P:
Fdn IRCCS Ist Neurol Carlo Besta, Unit Neurol & Neuropathol 5, Milan, Italy
Bandres-Ciga, S:
NIA, Ctr Alzheimers & Related Dementias, Bethesda, MD 20892 USA
Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD USA
Clarimon, J:
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Hosp Santa Creu & St Pau, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Hosp Santa Creu & St Pau, Barcelona, Spain
Colao, R:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Cruchaga, C:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Washington Univ, Sch Med, Neurogen & Informat Ctr, St Louis, MO USA
Danek, A:
LMU Klinikum, Neurol Klin, Munich, Germany
de Boer, SCM:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam Neurosci, Neurodegenerat, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia
de Rojas, I:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
di Costanzo, A:
Univ Molise, Dept Med & Hlth Sci V Tiberio, Ctr Res & Training Med Aging, Campobasso, Italy
Dickson, DW:
Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Diehl-Schmid, J:
Tech Univ Munich, Klinikum Rechts Isar, Dept Psychiat & Psychotherapy, Sch Med, Munich, Germany
Kbo Inn Salzach Klinikum, Wasserburg, Germany
Dobson-Stone, C:
Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia
Univ Sydney, Sch Med Sci, Sydney, NSW, Australia
Dols-Icardo, O:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Hosp Santa Creu & St Pau, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Hosp Santa Creu & St Pau, Barcelona, Spain
Donizetti, A:
Univ Naples Federico II, Dept Biol, Naples, Italy
Dopper, E:
Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands
Erasmus Univ, Med Ctr, Alzheimer Ctr, Rotterdam, Netherlands
Ferrari, C:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
Forloni, G:
Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy
Frangipane, F:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Fratiglioni, L:
Karolinska Inst, KI Alzheimer Dis Res Ctr, Dept NVS, Stockholm, Sweden
Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden
Kramberger, MG:
Ljubljana Univ Ljubljana, Med Fac, Univ Med Ctr, Dept Neurol, Ljubljana, Slovenia
Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Clin Geriatr, Huddinge, Sweden
Galimberti, D:
Fdn IRCCS CaGranda, Osped Maggiore Policlin, Milan, Italy
Local Hlth Author n2 Marca Trevigiana, Immunohematol & Transfus Med Serv, Treviso, Italy
Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy
Gallucci, M:
Local Hlth Author n2 Marca Trevigiana, Cognit Impairment Ctr, Treviso, Italy
García-González, P:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Ghidoni, R:
IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy
Giaccone, G:
Fdn IRCCS Ist Neurol Carlo Besta, Unit Neurol & Neuropathol 5, Milan, Italy
Graff, C:
Karolinska Inst, KI Alzheimer Dis Res Ctr, Dept NVS, Stockholm, Sweden
Karolinska Univ Hosp Solna, Unit Hereditary Dementia, Stockholm, Sweden
Graff-Radford, NR:
Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA
Grafman, J:
Shirley Ryan AbilityLab, Chicago, IL USA
Halliday, GM:
Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia
Univ Sydney, Sch Med Sci, Sydney, NSW, Australia
Hernandez, DG:
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Hjermind, LE:
Copenhagen Univ Hosp, Danish Dementia Res Ctr, Neurogenet Clin & Res Lab, Copenhagen, Denmark
Hodges, JR:
Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia
Holloway, G:
Univ Edinburgh, Anne Rowling Regenerat Neurol Clin, Edinburgh, Midlothian, Scotland
Huey, ED:
Brown Univ, Bio Med Psychiat & Human Behav, Providence, RI 02912 USA
Illán-Gala, I:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Hosp Santa Creu & St Pau, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Hosp Santa Creu & St Pau, Barcelona, Spain
Josephs, KA:
Mayo Clin, Dept Neurol, Rochester, MN USA
Knopman, DS:
Mayo Clin, Dept Neurol, Rochester, MN USA
Kristiansen, M:
UCL Genom, London, England
UCL Great Ormond St Inst Child Hlth, London, England
Zayed Ctr Res Rare Dis Children, London, England
Kwok, JB:
Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia
Univ Sydney, Sch Med Sci, Sydney, NSW, Australia
Leber, I:
Sorbonne Univ, INSERM, U1127, CNRS 7225,Inst Cerveau ICM, Paris, France
Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Neurol,Inst Memory & Alzheimers Dis, Paris, France
Leonard, HL:
NIA, Ctr Alzheimers & Related Dementias, Bethesda, MD 20892 USA
Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD USA
Data Tecn Int LLC, Washington, DC USA
DZNE Tubingen, Tubingen, Germany
Libri, I:
Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy
Lleo, A:
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Univ Autonoma Barcelona, Neurol Dept, Memory Unit, Hosp Santa Creu & St Pau, Barcelona, Spain
Univ Autonoma Barcelona, St Pau Biomed Res Inst, Hosp Santa Creu & St Pau, Barcelona, Spain
Mackenzie, IR:
Univ British Columbia, Dept Pathol, Vancouver, BC, Canada
Vancouver Coastal Hlth, Dept Pathol, Vancouver, BC, Canada
Madhan, GK:
UCL Genom, London, England
UCL Great Ormond St Inst Child Hlth, London, England
Zayed Ctr Res Rare Dis Children, London, England
Maletta, R:
ASPCZ, Reg Neurogenet Ctr, Lamezia Terme, Italy
Marquié, M:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Maver, A:
Univ Med Ctr Ljubljana, Clin Inst Genom Med, Ljubljana, Slovenia
Menendez-Gonzalez, M:
Hosp Univ Cent Asturias, Oviedo, Spain
Inst Invest Sanitaria Principado Asturias, Oviedo, Spain
Univ Oviedo, Dept Med, Oviedo, Spain
Milan, G:
Geriatr Ctr Frullone ASL NA1, Naples, Italy
Miller, BL:
Univ Calif San Francisco, Weill Inst Neurosci, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Univ Calif San Francisco, Global Brain Hlth Inst, San Francisco, CA 94143 USA
Morris, CM:
Newcastle Univ, Newcastle Brain Tissue Resource, Edwardson Bldg,Nuns Moor Rd, Newcastle Upon Tyne, Tyne & Wear, England
Morris, HR:
UCL Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, London, England
Nacmias, B:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
IRCCS Fdn Don Carlo Gnocchi, Florence, Italy
Newton, J:
Univ Edinburgh, Anne Rowling Regenerat Neurol Clin, Edinburgh, Midlothian, Scotland
Nielsen, JE:
Copenhagen Univ Hosp, Danish Dementia Res Ctr, Neurogenet Clin & Res Lab, Copenhagen, Denmark
Nilsson, C:
Lund Univ, Dept Clin Sci, Neurol, Lund, Sweden
Novelli, V:
Ctr Cardiol Monzino IRCCS, Milan, Italy
Padovani, A:
Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy
Pal, S:
Univ Edinburgh, Anne Rowling Regenerat Neurol Clin, Edinburgh, Midlothian, Scotland
Pasquier, F:
Univ Lille, Lille, France
CHU Lille, Lille, France
INSERM, Labex DISTALZ, LiCEND, Lille, France
Pastor, P:
Univ Hosp Germans Trias & Pujol, Dept Neurol, Unit Neurodegenerat Dis, Badalona, Spain
Germans Trias & Pujol Res Inst IGTP Badalona, Barcelona, Spain
Perneczky, R:
Ludwig Maximilians UnivMunich, LMU Hosp, Dept Psychiat & Psychotherapy, Munich, Germany
German Ctr Neurodegenerat Dis DZNE Munich, Munich, Germany
Munich Cluster Syst Neurol SyNergy, Munich, Germany
Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol AGE Res Unit, London, England
Univ Sheffield, Sheffield Inst Translat Neurosci SITraN, Sheffield, S Yorkshire, England
Peterlin, B:
Univ Med Ctr Ljubljana, Clin Inst Genom Med, Ljubljana, Slovenia
Petersen, RC:
Mayo Clin, Dept Neurol, Rochester, MN USA
Piguet, O:
Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia
Univ Sydney, Sch Psychol, Sydney, NSW, Australia
Pijnenburg, YAL:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam Neurosci, Neurodegenerat, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Puca, AA:
Univ Salerno, Dept Med Surg & Dent, Scuola Med Salernitana, Fisciano, Italy
IRCCS Multimed, Cardiovasc Res Unit, Milan, Italy
Rademakers, R:
Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
VIB, Ctr Mol Neurol, Antwerp, Belgium
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
Rainero, I:
Univ Torino, Rita Levi Montalcini, Dept Neurosci, Turin, Italy
AOUCitta Salute & Sci Torino, Dept Neurosci & Mental Hlth, Ctr Alzheimers Dis & Related Dementias, Turin, Italy
Reus, LM:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam Neurosci, Neurodegenerat, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA USA
Richardson, AMT:
Univ Manchester, Manchester Acad Hlth Sci Unit, Northern Care Alliance NHS Trust, Manchester Ctr Clin Neurosci, Manchester, Lancs, England
Riemenschneider, M:
Univ Saarland, Dept Psychiat, Homburg, Germany
Rogaeva, E:
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
Univ Toronto, Dept Med, Toronto, ON, Canada
Rogelj, B:
Jozef Stefan Inst, Dept Biotechnol, Ljubljana, Slovenia
Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana, Slovenia
Rollinson, S:
Univ Manchester, Sch Biol Sci, Div Neurosci & Expt Psychol, Manchester, Lancs, England
Rosen, H:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
Rossi, G:
Fdn IRCCS Ist Neurol Carlo Besta, Unit Neurol & Neuropathol 5, Milan, Italy
Rowe, JB:
Univ Cambridge, Dept Clin Neurosci, Cambridge, England
Cambridge Univ Hosp NHS Trust, Cambridge, England
Rubino, E:
Univ Torino, Rita Levi Montalcini, Dept Neurosci, Turin, Italy
AOUCitta Salute & Sci Torino, Dept Neurosci & Mental Hlth, Ctr Alzheimers Dis & Related Dementias, Turin, Italy
Ruiz, A:
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Res Ctr, Barcelona, Spain
Univ Int Catalunya, Ace Alzheimer Ctr Barcelona, Memory Clin, Barcelona, Spain
Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain
Salvi, E:
Fdn IRCCS Ist Neurol Carlo Besta, Unit Neuroalgol 3, Milan, Italy
Fdn IRCCS Ist Neurol Carlo Besta, Data Sci Ctr, Milan, Italy
Sanchez-Valle, R:
Fundacio Clin Barcelona IDIBAPS, Alzheimers Dis & Other Cognit Disorders Unit, Serv Neurol, Hosp Clin Barcelona, Barcelona, Spain
Sando, SB:
Univ Hosp Trondheim, Dept Neurol & Clin Neurophysiol, Trondheim, Norway
Norwegian Univ Sci & Technol, Dept Neuromed & Movement Sci, Fac Med & Hlth Sci, Trondheim, Norway
Santillo, AF:
Lund Univ, Fac Med, Clin Memory Res Unit, Dept Clin Sci, Lund, Sweden
Saxon, JA:
Univ Manchester, Manchester Acad Hlth Sci Unit, Northern Care Alliance NHS Trust, Manchester Ctr Clin Neurosci, Manchester, Lancs, England
Schlachetzki, JCM:
Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
Scholz, SW:
Natl Inst Neurol Disorders & Stroke, Neurodegenerat Dis Res Unit, Bethesda, MD USA
Johns Hopkins Univ, Med Ctr, Dept Neurol, Baltimore, MD 21218 USA
Seelaar, H:
Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands
Erasmus Univ, Med Ctr, Alzheimer Ctr, Rotterdam, Netherlands
Seeley, WW:
Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
Serpente, M:
Fdn IRCCS CaGranda, Osped Maggiore Policlin, Milan, Italy
Sorbi, S:
Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy
IRCCS Fdn Don Carlo Gnocchi, Florence, Italy
Sordon, S:
Univ Saarland, Dept Psychiat, Homburg, Germany
St George-Hyslop, P:
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
Univ Toronto, Dept Med, Toronto, ON, Canada
Columbia Univ, Dept Neurol, New York, NY USA
Thompson, JC:
Univ Manchester, Manchester Acad Hlth Sci Unit, Northern Care Alliance NHS Trust, Manchester Ctr Clin Neurosci, Manchester, Lancs, England
Univ Manchester, Sch Biol Sci, Div Neurosci & Expt Psychol, Manchester, Lancs, England
Van Broeckhoven, C:
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
VIB, Ctr Mol Neurol, Neurodegenerat Brain Dis, Antwerp, Belgium
Van Deerlin, VM:
Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA USA
Van der Lee, SJ:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Neurol, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam Neurosci, Neurodegenerat, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam UMC, Dept Clin Genet, Sect Genom Neurodegenerat Dis & Aging, Amsterdam, Netherlands
Van Swieten, J:
Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands
Erasmus Univ, Med Ctr, Alzheimer Ctr, Rotterdam, Netherlands
Tagliavini, F:
Fdn IRCCS Ist Neurol Carlo Besta, Unit Neurol & Neuropathol 5, Milan, Italy
van der Zee, J:
Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium
VIB, Ctr Mol Neurol, Neurodegenerat Brain Dis, Antwerp, Belgium
Vitale, E:
Natl Res Council CNR, Inst Biochem & Cell Biol, Naples, Italy
Kean Univ, Dept Biol, Sch Integrat Sci & Technol, Union, NJ USA
Waldo, ML:
Lund Univ, Dept Clin Sci, Clin Sci Helsingborg, Lund, Sweden
Yokoyama, JS:
Univ Calif San Francisco, Weill Inst Neurosci, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA
Univ Calif San Francisco, Global Brain Hlth Inst, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA
Nalls, MA:
NIA, Ctr Alzheimers & Related Dementias, Bethesda, MD 20892 USA
Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD USA
Data Tecn Int LLC, Washington, DC USA
Momeni, P:
Rona Holdings, Cupertino, CA USA
Singleton, AB:
NIA, Ctr Alzheimers & Related Dementias, Bethesda, MD 20892 USA
Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD USA
NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Hardy, J:
UK Dementia Res Inst UCL, London, England
UCL Queen Sq Inst Neurol, Dept Neurodegenerat Dis, London, England
UCL Queen Sq Inst Neurol, Reta Lila Weston Inst, London, England
NIHR Univ Coll London Hosp, Biomed Res Ctr, London, England
Hong Kong Univ Sci & Technol, Inst Adv Study, Hong Kong, Peoples R China
Escott-Price, V:
Cardiff Univ, UK Dementia Res Inst, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales
Trinity Coll Dublin, Dublin, Ireland
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