Clinical and research application of fluid bio markers in autosomal dominant Alzheimer's disease and Down syndrome
Por:
Carmona-Iragui, M, 'Connor, AO, Llibre-Guerra, J, Lao, PT, Ashton, NJ, Fortea, J, Sánchez-Valle, R
Publicada:
1 oct 2024
Ahead of Print:
1 oct 2024
Resumen:
Autosomal dominant Alzheimer's disease (ADAD) and Down syndrome (DS) constitute genetic forms of Alzheimer's disease (AD). The study of these forms has been crucial in understanding the biomarker changes and disease progression, notably in advancing our knowledge of the natural history of AD. However, some specific characteristics of biomarkers in genetically determined forms and, most importantly, the near full penetrance and predictability of disease onset lead to a very different context of use for biomarkers in these populations. This article delves into the similarities and differences in biomarker profiles between genetically determined AD and sporadic cases, discussing the implications for research and clinical practice. It also emphasizes the need to account for factors that may affect biomarker reliability differently in genetically determined AD. Enhancing our understanding of the disease will pave the way for more personalized therapeutic approaches for affected individuals.
Filiaciones:
Carmona-Iragui, M:
Univ Autonoma Barcelona, Hosp Santa Creu St Pau, Biomed Res Inst St Pau, Neurol Dept,St Pau Memory Unit, Barcelona, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
CIBERNED, Ctr Biomed Invest Network Neurodegenerat Dis, Madrid, Spain
'Connor, AO:
Tallaght Univ Hosp, Dept Neurol, Dublin, Ireland
Tallaght Univ Hosp, Inst Memory & Cognit, Dublin, Ireland
Llibre-Guerra, J:
Washington Univ, Sch Med St Louis, Dept Neurol, Dominantly Inherited Alzheimers Network Trials Uni, St Louis, MO USA
Lao, PT:
Columbia Univ, GH Sergievsky Ctr, Irving Med Ctr, New York, NY 10019 USA
Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, Irving Med Ctr, Dept Neurol, New York, NY 10019 USA
Ashton, NJ:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden
Kings Coll London, Inst Psychiat Psychol & Neurosci, Maurice Wohl Inst Clin Neurosci Inst, London, England
South London & Maudsley NHS Fdn, NIHR Biomed Res Ctr Mental Hlth, London, England
South London & Maudsley NHS Fdn, Biomed Res Unit Dementia, London, England
Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway
Fortea, J:
Univ Autonoma Barcelona, Hosp Santa Creu St Pau, Biomed Res Inst St Pau, Neurol Dept,St Pau Memory Unit, Barcelona, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
CIBERNED, Ctr Biomed Invest Network Neurodegenerat Dis, Madrid, Spain
Sánchez-Valle, R:
Univ Barcelona, Hosp Clin Barcelona, Fundacio Recerca Clin Barcelona IDIBAPS, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain
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