Exploring Plasma Coenzyme Q10 Status in Paediatric Dyslipidaemia
Por:
Minguez, B, de Los Santos, M, Garcia-Volpe, C, Molera, C, Paredes-Fuentes, AJ, Oliva, C, Arias, A, Rodriguez-Gonzalez, H, Yubero, D, Tondo, M, Santos-Ocaña, C, Meavilla, S, Artuch, R
Publicada:
1 ago 2024
Resumen:
Coenzyme Q10 (CoQ) is a ubiquitous lipid with different biological functions. In blood, there is a close relationship between CoQ status and cholesterol, which strongly supports the study of both molecules simultaneously. The objective of this study was to evaluate plasma CoQ, lipoprotein concentrations and CoQ/Chol ratio in a cohort of paediatric patients with different types of dyslipidaemias. A total of 60 paediatric patients were recruited (age range: 7 months-18 years), including 52 with different types of hypercholesterolemia, 2 with isolated hypertriglyceridemia and 6 with hypobetalipoproteinemia. Plasma CoQ was analysed by HPLC with electrochemical detection, and lipoprotein and cholesterol concentrations by standard automated methods. The lowest CoQ values were detected in patients with hypobetalipoproteinemia and in two cases of liver cirrhosis. Mean CoQ values were significantly higher in hypercholesterolemic patients compared to controls (average values 1.07 mu mol/L and 0.63 mu mol/L) while the CoQ/cholesterol ratio did not show differences (170 vs. 163, respectively). Mean CoQ values were significantly lower in the group of patients with hypobetalipoproteinemia compared to controls (mean CoQ values of 0.22 mu mol/L vs. 0.63 mu mol/L, respectively), while those of CoQ/cholesterol did not show differences. Pearson's correlation test showed a positive correlation between the CoQ and cholesterol values (r = 0.565, p < 0.001) and between the CoQ and the LDL cholesterol values (r = 0.610, p < 0.001). Our results suggest that it is advisable to analyse plasma CoQ and cholesterol concentrations in patients with hypobetalipoproteinemia and hypercholesterolemia associated with liver damage.
Filiaciones:
Minguez, B:
Hosp San Juan Dios, Gastroenterol & Nutr Dept, Barcelona 08950, Spain
de Los Santos, M:
Hosp San Juan Dios, Gastroenterol & Nutr Dept, Barcelona 08950, Spain
Garcia-Volpe, C:
Hosp San Juan Dios, Gastroenterol & Nutr Dept, Barcelona 08950, Spain
Molera, C:
Hosp San Juan Dios, Gastroenterol & Nutr Dept, Barcelona 08950, Spain
Paredes-Fuentes, AJ:
Hosp Clin Barcelona, Biochem & Mol Genet Dept, Div Inborn Errors Metab IBC, Barcelona 08036, Spain
Oliva, C:
Hosp Clin Barcelona, Biochem & Mol Genet Dept, Div Inborn Errors Metab IBC, Barcelona 08036, Spain
Arias, A:
Inst Recerca St Joan de Deu, Clin Biochem Dept, Barcelona 08950, Spain
Rodriguez-Gonzalez, H:
Inst Recerca St Joan de Deu, Clin Biochem Dept, Barcelona 08950, Spain
Yubero, D:
Hosp St Joan de Deu, Genet Dept, Barcelona 08950, Spain
Tondo, M:
Hosp Santa Creu i St Pau, Biomed Res Inst IIB St Pau, Dept Biochem, Barcelona 08041, Spain
Ctr Biomed Invest Network Diabet & Metab Dis CIBER, Madrid 28029, Spain
Santos-Ocaña, C:
Univ Pablo de Olavide, Ctr Andaluz Biol Desarrollo, Dept Fisiol Anat & Biol Celular, Seville 41013, Spain
Inst Salud Carlos III, U703 U729 CIBERER, Madrid 28029, Spain
Meavilla, S:
Hosp San Juan Dios, Gastroenterol & Nutr Dept, Barcelona 08950, Spain
Artuch, R:
Inst Recerca St Joan de Deu, Clin Biochem Dept, Barcelona 08950, Spain
Inst Salud Carlos III, U703 U729 CIBERER, Madrid 28029, Spain
gold
|