White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group
Por:
van Velzen, LS, Kelly, S, Isaev, D, Aleman, A, Aftanas, LI, Bauer, J, Baune, BT, Brak, IV, Carballedo, A, Connolly, CG, Couvy-Duchesne, B, Cullen, KR, Danilenko, KV, Dannlowski, U, Enneking, V, Filimonova, E, Foerster, K, Frodl, T, Gotlib, IH, Groenewold, NA, Grotegerd, D, Harris, MA, Hatton, SN, Hawkins, EL, Hickie, IB, Ho, TC, Jansen, A, Kircher, T, Klimes-Dougan, B, Kochunov, P, Krug, A, Lagopoulos, J, Lee, R, Lett, TA, Li, M, MacMaster, FP, Martin, NG, McIntosh, AM, McLellan, Q, Meinert, S, Nenadic, I, Osipov, E, Penninx, BWJH, Portella, MJ, Repple, J, Roos, A, Sacchet, MD, Saemann, PG, Schnell, K, Shen, XY, Sim, K, Stein, DJ, van Tol, MJ, Tomyshev, AS, Tozzi, L, Veer, IM, Vermeiren, R, Vives-Gilabert, Y, Walter, H, Walter, M, van der Wee, NJA, van der Werff, SJA, Schreiner, MW, Whalley, HC, Wright, MJ, Yang, TT, Zhu, A, Veltman, DJ, Thompson, PM, Jahanshad, N, Schmaal, L
Publicada:
1 jul 2020
Resumen:
Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12-88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Working Group of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium. Processing of diffusion tensor imaging (DTI) data and statistical analyses were harmonized across sites and effects were meta-analyzed across studies. We observed subtle, but widespread, lower fractional anisotropy (FA) in adult MDD patients compared with controls in 16 out of 25 WM tracts of interest (Cohen'sdbetween 0.12 and 0.26). The largest differences were observed in the corpus callosum and corona radiata. Widespread higher radial diffusivity (RD) was also observed (all Cohen'sdbetween 0.12 and 0.18). Findings appeared to be driven by patients with recurrent MDD and an adult age of onset of depression. White matter microstructural differences in a smaller sample of adolescent MDD patients and controls did not survive correction for multiple testing. In this coordinated and harmonized multisite DTI study, we showed subtle, but widespread differences in WM microstructure in adult MDD, which may suggest structural disconnectivity in MDD.
Filiaciones:
van Velzen, LS:
Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands
Natl Ctr Excellence Youth Mental Hlth, Orygen, Parkville, Vic, Australia
Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia
Kelly, S:
Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA 02115 USA
Harvard Med Sch, Brigham & Womens Hosp, Psychiat Neuroimaging Lab, Boston, MA 02115 USA
Isaev, D:
Univ Southern Calif, Imaging Genet Ctr, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA
Aleman, A:
Univ Groningen, Univ Med Ctr Groningen, Cognit Neurosci Ctr, Groningen, Netherlands
Aftanas, LI:
FSSBI Sci Res Inst Physiol & Basic Med, Lab Affect Cognit & Translat Neurosci, Novosibirsk, Russia
Novosibirsk State Univ, Dept Neurosci, Novosibirsk, Russia
Bauer, J:
Univ Munster, Inst Clin Radiol, Munster, Germany
Baune, BT:
Univ Munster, Dept Psychiat, Munster, Germany
Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia
Univ Melbourne, Florey Inst Neurosci & Mental Heatlh, Melbourne, Vic, Australia
Brak, IV:
FSSBI Sci Res Inst Physiol & Basic Med, Lab Affect Cognit & Translat Neurosci, Novosibirsk, Russia
Novosibirsk State Univ, Lab Expt & Translat Neurosci, Novosibirsk, Russia
Carballedo, A:
Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland
Trinity Coll Dublin, Trinity Inst Neurosci, Dublin, Ireland
North Dublin Mental Hlth Serv, Dublin, Ireland
Connolly, CG:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
Florida State Univ, Dept Biomed Sci, Tallahassee, FL 32306 USA
Couvy-Duchesne, B:
Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia
Cullen, KR:
Univ Minnesota, Dept Psychiat & Behav Sci, Minneapolis, MN USA
Danilenko, KV:
FSSBI Sci Res Inst Physiol & Basic Med, Lab Affect Cognit & Translat Neurosci, Novosibirsk, Russia
Dannlowski, U:
Univ Munster, Dept Psychiat, Munster, Germany
Enneking, V:
Univ Munster, Dept Psychiat, Munster, Germany
Filimonova, E:
FSSBI Sci Res Inst Physiol & Basic Med, Lab Affect Cognit & Translat Neurosci, Novosibirsk, Russia
Foerster, K:
Univ Munster, Dept Psychiat, Munster, Germany
Frodl, T:
Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland
Trinity Coll Dublin, Trinity Inst Neurosci, Dublin, Ireland
Otto von Guericke Univ, Dept Psychiat & Psychotherapy, Magdeburg, Germany
German Ctr Neurodegenerat Dis, Magdeburg, Germany
Gotlib, IH:
Stanford Univ, Dept Psychol, Stanford, CA USA
Groenewold, NA:
Univ Cape Town, Dept Psychiat, Cape Town, South Africa
Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Dept Psychiat, Groningen, Netherlands
Grotegerd, D:
Univ Munster, Dept Psychiat, Munster, Germany
Harris, MA:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Hatton, SN:
Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth Team, Camperdown, NSW, Australia
Hawkins, EL:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Hickie, IB:
Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth Team, Camperdown, NSW, Australia
Ho, TC:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
Stanford Univ, Dept Psychol, Stanford, CA USA
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
Jansen, A:
Univ Marburg, Dept Psychiat, Marburg, Germany
Kircher, T:
Univ Marburg, Dept Psychiat, Marburg, Germany
Klimes-Dougan, B:
Univ Minnesota, Dept Psychol, Minneapolis, MN USA
Kochunov, P:
Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21201 USA
Krug, A:
Univ Marburg, Dept Psychiat, Marburg, Germany
Lagopoulos, J:
Sunshine Coast Mind & Neurosci Thompson Inst, Birtinya, Qld, Australia
Lee, R:
Inst Mental Hlth, Res Div, Singapore, Singapore
Lett, TA:
Charite Univ Med Berlin, Div Mind & Brain Res, Dept Psychiat & Psychotherapy CCM, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Berlin Inst Hlth, Berlin, Germany
Li, M:
Univ Magdeburg, Dept Neurol, Magdeburg, Germany
MacMaster, FP:
Univ Calgary, Psychiat & Paediat, Calgary, AB, Canada
Strateg Clin Network Addict & Mental Hlth, Calgary, AB, Canada
Martin, NG:
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
McIntosh, AM:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland
McLellan, Q:
Univ Calgary, Dept Neurosci, Calgary, AB, Canada
Alberta Childrens Prov Gen Hosp, Res Inst, Calgary, AB, Canada
Meinert, S:
Univ Munster, Dept Psychiat, Munster, Germany
Nenadic, I:
Univ Marburg, Dept Psychiat, Marburg, Germany
Osipov, E:
Novosibirsk State Univ, Lab Expt & Translat Neurosci, Novosibirsk, Russia
Penninx, BWJH:
Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands
Portella, MJ:
Inst Biomed Res St Pau, Dept Psychiat, Barcelona, Spain
CIBERSAM, Madrid, Spain
Univ Autonoma Barcelona, Barcelona, Spain
Repple, J:
Univ Munster, Dept Psychiat, Munster, Germany
Roos, A:
Stellenbosch Univ, Dept Psychiat, SAMRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa
Sacchet, MD:
Harvard Med Sch, Ctr Depress Anxiety & Stress Res, McLean Hosp, Belmont, MA USA
Saemann, PG:
Max Planck Inst Psychiat, Munich, Germany
Schnell, K:
Heidelberg Univ, Dept Psychiat, Heidelberg, Germany
Shen, XY:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Sim, K:
Inst Mental Hlth, West Reg & Res Div, Singapore, Singapore
Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore
Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Stein, DJ:
Univ Cape Town, Dept Psychiat & Neurosci Inst, SAMRC Unit Risk & Resilience Mental Disorders, Cape Town, South Africa
van Tol, MJ:
Univ Groningen, Univ Med Ctr Groningen, Cognit Neurosci Ctr, Groningen, Netherlands
Tomyshev, AS:
Mental Hlth Res Ctr, Moscow, Russia
Tozzi, L:
Otto von Guericke Univ, Dept Psychiat & Psychotherapy, Magdeburg, Germany
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
Veer, IM:
Charite Univ Med Berlin, Div Mind & Brain Res, Dept Psychiat & Psychotherapy CCM, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Berlin Inst Hlth, Berlin, Germany
Vermeiren, R:
Leiden Univ, Med Ctr, Curium LUMC Child & Adolescent Psychiat, Leiden, Netherlands
Leiden Inst Brain & Cognit, Leiden, Netherlands
Leiden Univ, Inst Psychol, Leiden, Netherlands
Vives-Gilabert, Y:
Univ Politecn Valencia, Inst ITACA, Valencia, Spain
Walter, H:
Charite Univ Med Berlin, Div Mind & Brain Res, Dept Psychiat & Psychotherapy CCM, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Berlin Inst Hlth, Berlin, Germany
Walter, M:
Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany
van der Wee, NJA:
Leiden Inst Brain & Cognit, Leiden, Netherlands
Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands
van der Werff, SJA:
Leiden Inst Brain & Cognit, Leiden, Netherlands
Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands
Schreiner, MW:
Univ Minnesota, Dept Psychol, Minneapolis, MN USA
Whalley, HC:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Wright, MJ:
Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia
Yang, TT:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
Zhu, A:
Univ Southern Calif, Imaging Genet Ctr, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA
Veltman, DJ:
Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands
Amsterdam Neurosci, Amsterdam, Netherlands
Thompson, PM:
Univ Southern Calif, Imaging Genet Ctr, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA
Jahanshad, N:
Univ Southern Calif, Imaging Genet Ctr, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA
Schmaal, L:
Natl Ctr Excellence Youth Mental Hlth, Orygen, Parkville, Vic, Australia
Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia
Green Published, Green Accepted, Hybrid Gold
|