Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study
Por:
Ulugut, H, Bertoux, M, Younes, K, Montembeault, M, Fumagalli, GG, Samanci, B, Illan-Gala, I, Kuchcinski, G, Leroy, M, Thompson, JC, Kobylecki, C, Santillo, AF, Englund, E, Waldö, ML, Riedl, L, van den Stock, J, Vandenbulcke, M, Vandenberghe, R, Laforce, R Jr, Ducharme, S, Pressman, PS, Caramelli, P, de Souza, LC, Takada, LT, Gurvit, H, Hansson, O, Diehl-Schmid, J, Galimberti, D, Pasquier, F, Miller, BL, Scheltens, P, Ossenkoppele, R, van der Flier, WM, Barkhof, F, Fox, NC, Sturm, VE, Miyagawa, T, Whitwell, JL, Boeve, B, Rohrer, JD, Gorno-Tempini, ML, Josephs, KA, Snowden, J, Warren, JD, Rankin, KP, Pijnenburg, YAL
Publicada:
10 jul 2024
Ahead of Print:
1 jul 2024
Resumen:
INTRODUCTIONAlthough frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.METHODSRetrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments.RESULTSCommon symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations.DISCUSSIONThis study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients.Highlights This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.
Filiaciones:
Ulugut, H:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, De Boelelaan, Amsterdam, Netherlands
Univ Calif San Francisco, UCSF Weill Inst Neurosci, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA
Bertoux, M:
Univ Lille, Lille Neurosci & Cognit U1172, Inserm, CHU Lille,LiCEND, Lille, France
Labex DistALZ, Lille, France
Younes, K:
Univ Calif San Francisco, UCSF Weill Inst Neurosci, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA
Stanford Univ, Stanford Neurosci Hlth Ctr, Dept Neurol, Palo Alto, CA USA
Montembeault, M:
Univ Calif San Francisco, UCSF Weill Inst Neurosci, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA
McGill Univ, Douglas Mental Hlth Univ Inst, McGill Univ Hlth Ctr, Dept Psychiat, Montreal, PQ, Canada
Fumagalli, GG:
Univ Milan, Dept Neurol, Milan, Italy
Univ Trento, Ctr Mind Brain Sci, UNITN?CIMEC, Mattarello, Trentino, Italy
Samanci, B:
Istanbul Univ, Dept Neurol, Istanbul, Turkiye
Illan-Gala, I:
Univ Autonoma Barcelona, Hosp Santa & Creu St Pau, Biomed Res Inst St Pau, Dept Neurol,St Pau Memory Unit, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERNE, Madrid, Spain
Kuchcinski, G:
Univ Lille, Lille Neurosci & Cognit U1172, Inserm, CHU Lille,LiCEND, Lille, France
Labex DistALZ, Lille, France
Leroy, M:
Univ Lille, Lille Neurosci & Cognit U1172, Inserm, CHU Lille,LiCEND, Lille, France
Labex DistALZ, Lille, France
Thompson, JC:
Salford Royal NHS Fdn Trust, Greater Manchester Neurosci Ctr, Cerebral Funct Unit, Salford, England
Univ Manchester, Fac Biol Med & Hlth, Div Neurosci & Expt Psychol, Manchester, England
Kobylecki, C:
Manchester Ctr Clin Neurosci NHS Fdn Trust, Dept Neurol, Salford, England
Univ Manchester, Div Neurosci, Manchester, England
Santillo, AF:
Lund Univ, Clin Memory Res Unit, Dept Clin Sci, Fac Med, Lund, Sweden
Englund, E:
Lund Univ, Dept Clin Sci, Div Pathol, Lund, Sweden
Waldö, ML:
Lund Univ, Dept Clin Sci, Div Pathol, Lund, Sweden
Riedl, L:
Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany
van den Stock, J:
Leuven Brain Inst, Dept Neurosci, Neuropsychiat, Leuven, Belgium
Vandenbulcke, M:
Leuven Brain Inst, Dept Neurosci, Neuropsychiat, Leuven, Belgium
Vandenberghe, R:
Univ Hosp Leuven, Dept Neurol, Leuven, Belgium
Laforce, R Jr:
Laval Univ, Dept Sci Neurol, Clin Interdisciplinaire Memoire CIME, Quebec City, PQ, Canada
Ducharme, S:
McGill Univ, Douglas Mental Hlth Univ Inst, McGill Univ Hlth Ctr, Dept Psychiat, Montreal, PQ, Canada
Pressman, PS:
Univ Colorado, Dept Neurol, Behav Neurol Sect, Anschutz Med Campus, Aurora, CO USA
Caramelli, P:
Univ Fed Minas Gerais, Fac Med, Dept Internal Med, Behav & Cognit Neurol Unit, Belo Horizonte, MG, Brazil
de Souza, LC:
Univ Fed Minas Gerais, Fac Med, Dept Internal Med, Behav & Cognit Neurol Unit, Belo Horizonte, MG, Brazil
Takada, LT:
Univ Sao Paulo, Med Sch, Hosp Clin, Cognit & Behav Unit,Dept Neurol, Sao Paulo, Brazil
Gurvit, H:
Istanbul Univ, Dept Neurol, Istanbul, Turkiye
Hansson, O:
Lund Univ, Clin Memory Res Unit, Dept Clin Sci, Fac Med, Lund, Sweden
Diehl-Schmid, J:
Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany
Kbo Inn Salzach Klinikum, Clin Ctr Psychiat Psychotherapy Psychosomat Med Ge, Wasserburg am Inn, Germany
Galimberti, D:
Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy
Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Milan, Italy
Pasquier, F:
Univ Lille, Lille Neurosci & Cognit U1172, Inserm, CHU Lille,LiCEND, Lille, France
Labex DistALZ, Lille, France
Miller, BL:
Univ Calif San Francisco, UCSF Weill Inst Neurosci, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA
Scheltens, P:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, De Boelelaan, Amsterdam, Netherlands
Ossenkoppele, R:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, De Boelelaan, Amsterdam, Netherlands
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Radiol, Amsterdam Neurosci, Amsterdam, Netherlands
van der Flier, WM:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, De Boelelaan, Amsterdam, Netherlands
Barkhof, F:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Radiol, Amsterdam Neurosci, Amsterdam, Netherlands
UCL, UCL Inst Neurol & Healthcare Engn, London, England
Fox, NC:
UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England
Sturm, VE:
Univ Calif San Francisco, UCSF Weill Inst Neurosci, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA
Miyagawa, T:
Mayo Clin, Dept Neurol, Rochester, MN USA
Whitwell, JL:
Mayo Clin, Dept Radiol, Rochester, MN USA
Boeve, B:
Mayo Clin, Dept Neurol, Rochester, MN USA
Rohrer, JD:
UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England
Gorno-Tempini, ML:
Univ Calif San Francisco, UCSF Weill Inst Neurosci, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA
Univ Calif San Francisco, UCSF Weill Inst Neurosci, Dyslexia Ctr, San Francisco, CA USA
Josephs, KA:
Mayo Clin, Dept Neurol, Rochester, MN USA
Snowden, J:
Salford Royal NHS Fdn Trust, Greater Manchester Neurosci Ctr, Cerebral Funct Unit, Salford, England
Univ Manchester, Fac Biol Med & Hlth, Div Neurosci & Expt Psychol, Manchester, England
Warren, JD:
UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England
Rankin, KP:
Univ Calif San Francisco, UCSF Weill Inst Neurosci, Memory & Aging Ctr, Dept Neurol, San Francisco, CA USA
Pijnenburg, YAL:
Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, De Boelelaan, Amsterdam, Netherlands
Lund Univ, Div Clin Sci Helsingborg, Dept Clin Sci Lund, Lund, Sweden
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