Sex differences in neural projections of fear memory processing in mice and humans
Por:
Florido, A, Velasco, ER, Romero, LR, Acharya, N, Blasco, IJM, Nabás, JF, Perez-Caballero, L, Rivero, G, Olabarrieta, E, Nuñez-delMoral, A, González-Parra, JA, Porta-Casteràs, D, Cano, M, Steward, T, Antony, MS, Cardoner, N, Torrubia, R, Jackson, AC, Fullana, MA, Andero, R
Publicada:
10 jul 2024
Resumen:
It remains unexplored in the field of fear memory whether functional neuronal connectivity between two brain areas is necessary for one sex but not the other. Here, we show that chemogenetic silencing of centromedial (CeM)-Tac2 fibers in the lateral posterior BNST (BNSTpl) decreased fear memory consolidation in male mice but not females. Optogenetic excitation of CeM-Tac2 fibers in the BNSTpl exhibited enhanced inhibitory postsynaptic currents in males compared to females. In vivo calcium imaging analysis revealed a sex-dimorphic fear memory engram in the BNSTpl. Furthermore, in humans, the single-nucleotide polymorphism (SNP) in the Tac2 receptor (rs2765) (TAC3R) decreased CeM-BNST connectivity in a fear task, impaired fear memory consolidation, and increased the expression of the TAC3R mRNA in AA-carrier men but not in women. These sex differences in critical neuronal circuits underlying fear memory formation may be relevant to human neuropsychiatric disorders with fear memory alterations such as posttraumatic stress disorder.
Filiaciones:
Florido, A:
Univ Autonoma Barcelona, Inst Neurociencies, Cerdanyola Del Valles, Barcelona, Spain
Univ Autonoma Barcelona, Dept Psicobiol & Metodol Ciencies Salut, Cerdanyola Del Valles, Barcelona, Spain
Velasco, ER:
Univ Autonoma Barcelona, Inst Neurociencies, Cerdanyola Del Valles, Barcelona, Spain
Hosp Univ Vall dHebron, Inst Catala Salut icS, Dept Radiol, Barcelona, Spain
Romero, LR:
Univ Autonoma Barcelona, Inst Neurociencies, Cerdanyola Del Valles, Barcelona, Spain
Acharya, N:
Univ Autonoma Barcelona, Inst Neurociencies, Cerdanyola Del Valles, Barcelona, Spain
Blasco, IJM:
Univ Autonoma Barcelona, Inst Neurociencies, Cerdanyola Del Valles, Barcelona, Spain
Nabás, JF:
Univ Autonoma Barcelona, Inst Neurociencies, Cerdanyola Del Valles, Barcelona, Spain
Perez-Caballero, L:
Univ Autonoma Barcelona, Inst Neurociencies, Cerdanyola Del Valles, Barcelona, Spain
Univ Autonoma Barcelona, Dept Psicobiol & Metodol Ciencies Salut, Cerdanyola Del Valles, Barcelona, Spain
Rivero, G:
Univ Basque Country, UPV EHU, Dept Pharmacol, Leioa, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Biobizkaia Hlth Res Inst, Baracaldo, Spain
Olabarrieta, E:
Univ Basque Country, UPV EHU, Dept Pharmacol, Leioa, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Nuñez-delMoral, A:
Univ Basque Country, UPV EHU, Dept Pharmacol, Leioa, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
González-Parra, JA:
IMIM Hosp Mar Med Res Inst, Cell Type Mech Normal & Pathol Behav, Barcelona, Spain
Porta-Casteràs, D:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Recerca St Pau IR ST PAU, St Pau Mental Hlth Res Grp, Barcelona, Spain
Parc Tauli Univ Hosp, Inst Invest & Innovacio Sanitaria Parc Tauli i I3P, Mental Hlth Dept, Unitat Neurociencia Traslac, Barcelona, Spain
Univ Autonoma Barcelona, Sch Med Bellaterra, Dept Psychiat & Forens Med, Barcelona, Spain
Cano, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Recerca St Pau IR ST PAU, St Pau Mental Hlth Res Grp, Barcelona, Spain
Steward, T:
Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia
Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia
Antony, MS:
Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT USA
Cardoner, N:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Recerca St Pau IR ST PAU, St Pau Mental Hlth Res Grp, Barcelona, Spain
Parc Tauli Univ Hosp, Inst Invest & Innovacio Sanitaria Parc Tauli i I3P, Mental Hlth Dept, Unitat Neurociencia Traslac, Barcelona, Spain
Univ Autonoma Barcelona, Sch Med Bellaterra, Dept Psychiat & Forens Med, Barcelona, Spain
Torrubia, R:
Univ Autonoma Barcelona, Dept Psiquiatria & Med legal, Unitat Psicol Med, Bellaterra, Barcelona, Spain
Univ Autonoma Barcelona, Inst Neurociencies, Bellaterra, Barcelona, Spain
Jackson, AC:
Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT USA
Inst Brain & Cognit Sci IBACS, Storrs, CT USA
Fullana, MA:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Inst Neurosci, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Adult Psychiat & Psychol Dept, Barcelona, Spain
Andero, R:
Univ Autonoma Barcelona, Inst Neurociencies, Cerdanyola Del Valles, Barcelona, Spain
Univ Autonoma Barcelona, Dept Psicobiol & Metodol Ciencies Salut, Cerdanyola Del Valles, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Parc Tauli Hosp Univ, Inst Invest & Innovacio Parc Tauli I3Pt, Unitat Neurociencia Traslac, Sabadell, Spain
ICREA, Barcelona, Spain
Green Published, gold
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