Trait anxiety is associated with attentional brain networks
Por:
De la Peña-Arteaga, V, Chavarría-Elizondo, P, Juaneda-Seguí, A, Martínez-Zalacaín, I, Morgado, P, Menchón, JM, Picó-Pérez, M, Fullana, MA, Soriano-Mas, C
Publicada:
1 jun 2024
Ahead of Print:
1 mar 2024
Resumen:
Trait anxiety is a well-established risk factor for anxiety and depressive disorders, yet its neural correlates are not clearly understood. In this study, we investigated the neural correlates of trait anxiety in a large sample (n = 179) of individuals who completed the trait and state versions of the State-Trait Anxiety Inventory and underwent resting-state functional magnetic resonance imaging. We used independent component analysis to characterize individual resting-state networks (RSNs), and multiple regression analyses to assess the relationship between trait anxiety and intrinsic connectivity. Trait anxiety was significantly associated with intrinsic connectivity in different regions of three RSNs (dorsal attention network, default mode network, and auditory network) when controlling for state anxiety. These RSNs primarily support attentional processes. Notably, when state anxiety was not controlled for, a different pattern of results emerged, highlighting the importance of considering this factor in assessing the neural correlates of trait anxiety. Our findings suggest that trait anxiety is uniquely associated with resting-state brain connectivity in networks mainly supporting attentional processes. Moreover, controlling for state anxiety is crucial when assessing the neural correlates of trait anxiety. These insights may help refine current neurobiological models of anxiety and identify potential targets for neurobiologically-based interventions.
Filiaciones:
De la Peña-Arteaga, V:
Inst Invest Biomed Bellvitge IDIBLL, Neurosci Program, Psychiat & Mental Hlth Grp, Lhospitalet De Llobregat, Spain
Inst Recerca St Pau IR SANT PAU, St Pau Mental Hlth Res Grp, Barcelona, Spain
Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Med, Braga, Portugal
Chavarría-Elizondo, P:
Inst Invest Biomed Bellvitge IDIBLL, Neurosci Program, Psychiat & Mental Hlth Grp, Lhospitalet De Llobregat, Spain
Univ Barcelona UB, Sch Med, Dept Clin Sci, Lhospitalet De Llobregat, Spain
Inst Salud Carlos III ISCIII, Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Juaneda-Seguí, A:
Inst Invest Biomed Bellvitge IDIBLL, Neurosci Program, Psychiat & Mental Hlth Grp, Lhospitalet De Llobregat, Spain
Univ Barcelona UB, Sch Med, Dept Clin Sci, Lhospitalet De Llobregat, Spain
Martínez-Zalacaín, I:
Inst Invest Biomed Bellvitge IDIBLL, Neurosci Program, Psychiat & Mental Hlth Grp, Lhospitalet De Llobregat, Spain
Univ Barcelona UB, Sch Med, Dept Clin Sci, Lhospitalet De Llobregat, Spain
Morgado, P:
Univ Minho, Life & Hlth Sci Res Inst ICVS, Sch Med, Braga, Portugal
ICVS 3BS, PT Govt Associate Lab, Braga, Portugal
2CA Clin Acad Ctr, Braga, Portugal
Picó-Pérez, M:
Univ Jaume 1, Dept Psicol Basica Clin & Psicobiol, Castellon de La Plana, Spain
Fullana, MA:
Inst Salud Carlos III ISCIII, Network Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain
Hosp Clin Barcelona, Inst Neurosci, Adult Psychiat & Psychol Dept, Barcelona, Spain
Hosp Clin Barcelona, IDIBAPS, Dept Psychiat, Imaging Mood & Anxiety Related Disorders IMARD Gr, Barcelona 08036, Spain
Univ Barcelona UB, Inst Neurosci, Dept Social Psychol & Quantitat Psychol, Barcelona, Spain
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