Real-World Long-Term Effectiveness of Risankizumab Among Patients with Moderate-to-Severe Psoriasis: Analysis from an International Medical Chart Review (RAPID) Study
Por:
Pinter, A, Soliman, AM, Pivneva, I, Ghanbariamin, R, Yang, M, Truong, B, Puig, L, Lebwohl, M
Publicada:
1 may 2024
Ahead of Print:
1 may 2024
Resumen:
Introduction Real-world data on the efficacy of risankizumab (RZB) in clinical moderate-to-severe plaque psoriasis (PsO) are limited. The RAPID study assessed real-world clinical and patient-reported outcomes in RZB-treated PsO patients using data collected from dermatologists in Canada, the Czech Republic, Germany, Japan, and Poland.Methods This ongoing, retrospective chart review collected data from medical records of RZB-treated adults with moderate-to-severe PsO (09/2022-06/2023). Eligible patients received RZB, had >= 12 months of medical records after RZB initiation (index date), and had Psoriasis Area and Severity Index (PASI), Investigator Global Assessment (IGA), or static Physician's Global Assessment (sPGA) scores >= 3 months before and up to 18 months after the index date. The proportion of patients achieving a clear/almost clear PsO (IGA/sPGA = 0/1), PASI <= 1, Dermatology Life Quality Index (DLQI) = 0/1, and a 90%/100% improvement from baseline in PASI as well as the mean changes in PASI, DLQI, itch, and skin pain scores at 12 and 18 months were reported for patients with non-missing assessments at baseline and 12 months.Results Most patients (66.4%) were male, 74.0% were biologic na & iuml;ve, and 73.0% had scalp PsO. Mean baseline IGA/sPGA was 3.7 +/- 0.5, with a mean PASI of 23.3 +/- 11.8. After 12 months, 86.1% of patients reported IGA/sPGA <= 1, and 75.7% achieved PASI90; these further increased to 91.1% and 80.5% at 18 months. DLQI, itch, and skin pain scores improved over time.Conclusions These data demonstrated the durable, real-world effectiveness of RZB in patients with moderate-to-severe PsO through continued improvement in disease and symptom severity over 18 months, with most of the patients reporting clear/almost clear skin.
Filiaciones:
Pinter, A:
Univ Hosp Frankfurt Main, Dept Dermatol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany
Soliman, AM:
AbbVie Inc, Chicago, IL USA
Pivneva, I:
Anal Grp Inc, Montreal, PQ, Canada
Ghanbariamin, R:
Anal Grp Inc, Boston, MA USA
Yang, M:
Anal Grp Inc, Boston, MA USA
Truong, B:
AbbVie Inc, Chicago, IL USA
Puig, L:
Hosp Santa Creu & Sant Pau, Dept Dermatol, Barcelona, Spain
Lebwohl, M:
Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY USA
Green Published, gold
|