Physicochemical Compatibility of Ceftolozane-Tazobactam with Parenteral Nutrition
Por:
De Pourcq, JT, Riera, A, Gras, L, Garin, N, Busquets, MA, Cardenete, J, Cardona, D, Riera, P
Publicada:
1 jul 2024
Resumen:
Ceftolozane-tazobactam (CT) is used for the treatment of complicated infections and for multidrug-resistant strains of Pseudomonas aeruginosa and extended-spectrum beta-lactamase-producing enterobacteria. In certain cases, simultaneous administration of CT and parenteral nutrition (PN) may be required, but compatibility of Y-site co-administration is unknown. The aim of this study was to analyse the physicochemical compatibility of CT Y-site administered with PN. We evaluated a protocolized PN approach for critical patients in our center. We studied both bolus infusion (2 g ceftolozane/1 g tazobactam in 1 h) and continuous infusion (CI) (6 g ceftolozane/3 g tazobactam) strategies. Samples were visually observed against light, microscopically inspected, and pH was analysed using a pH meter. The mean lipid droplet diameter (MDD) was determined via dynamic light scattering. CT concentration was quantified using HPLC-HRMS. No alterations were observed through visual or microscopic inspection. Changes in pH were <= 0.2, and changes in osmolarity were less than 5%. MDD remained below 500 nm (284.5 +/- 2.1 for bolus CT and 286.8 +/- 7.5 for CI CT). CT concentrations at t = 0 h and t = 24 h remained within prespecified parameters in both infusion strategies. CT is physiochemically compatible with PN during simulated Y-site administration at the tested concentration and infusion rates.
Filiaciones:
De Pourcq, JT:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Pharm, Barcelona 08025, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona 08025, Spain
Inst Recerca St Pau IR SANT PAU, Barcelona 08041, Spain
Riera, A:
Hosp St Pau & Santa Tecla, Dept Pharm, Tarragona 43003, Spain
Gras, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Pharm, Barcelona 08025, Spain
Inst Recerca St Pau IR SANT PAU, Barcelona 08041, Spain
Garin, N:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Pharm, Barcelona 08025, Spain
Univ Ramon Llull, Sch Hlth Sci Blanquerna, Barcelona 08025, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28007, Spain
Busquets, MA:
Univ Barcelona, Inst Nanosci & Nanotechnol IN2UB, Barcelona 08028, Spain
Univ Barcelona, Fac Pharm & Food Sci, Dept Pharm & Pharmaceut Technol & Phys Chem, Barcelona 08028, Spain
Cardenete, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Pharm, Barcelona 08025, Spain
Inst Recerca St Pau IR SANT PAU, Barcelona 08041, Spain
Cardona, D:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Pharm, Barcelona 08025, Spain
Riera, P:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Pharm, Barcelona 08025, Spain
Inst Recerca St Pau IR SANT PAU, Barcelona 08041, Spain
Inst Salud Carlos III, CIBER Enfermedades Raras CIBERER, Madrid 28029, Spain
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