Characterization of white matter hyperintensities in Down syndrome
Por:
Morcillo-Nieto, AO, Zsadanyi, SE, Arriola-Infante, JE, Carmona-Iragui, M, Montal, V, Pegueroles, J, Aranha, MR, Vaque-Alcazar, L, Padilla, C, Benejam, B, Videla, L, Barroeta, I, Fernandez, S, Altuna, M, Gimenez, S, Gonzalez-Ortiz, S, Bargallo, N, Ribas, L, Arranz, J, Torres, S, Iulita, MF, Belbin, O, Camacho, V, Alcolea, D, Lleo, A, Fortea, J, Bejanin, A
Publicada:
1 ago 2024
Ahead of Print:
1 ago 2024
Resumen:
INTRODUCTION: In Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer's disease (AD) biomarkers remain largely unexplored. METHODS: In 261 DS adults and 131 euploid controls, fluid-attenuated inversion recovery magnetic resonance imaging scans were segmented and WMHs were extracted in concentric white matter layers and lobar regions. We tested associations with AD clinical stages, sociodemographic data, cerebrospinal fluid (CSF) AD biomarkers, and gray matter (GM) volume. RESULTS: In DS, total WMHs arose at age 43 and showed stronger associations with age than in controls. WMH volume increased along the AD continuum, particularly in periventricular regions, and frontal, parietal, and occipital lobes. Associations were found with CSF biomarkers and temporo-parietal GM volumes. DISCUSSION: WMHs increase 10 years before AD symptom onset in DS and are closely linked with AD biomarkers and neurodegeneration. This suggests a direct connection to AD pathophysiology, independent of vascular risks.
Filiaciones:
Morcillo-Nieto, AO:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Zsadanyi, SE:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Arriola-Infante, JE:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Carmona-Iragui, M:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Montal, V:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Barcelona Supercomp Ctr, Barcelona, Spain
Pegueroles, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Aranha, MR:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Vaque-Alcazar, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Fac Med & Hlth Sci, Dept Med, Barcelona, Spain
Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain
Padilla, C:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Univ Oberta Catalunya, Estudis Ciencies Salut, Barcelona, Spain
Benejam, B:
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Videla, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Barroeta, I:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fernandez, S:
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Altuna, M:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fdn CITA Alzheimer Fundazia, Donostia San Sebastian, Spain
Gimenez, S:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Hosp Santa Creu i St Pau, Inst Invest Biomed St Pau IIB ST PAU, Resp Dept, Multidisciplinary Sleep Unit, Barcelona, Spain
Gonzalez-Ortiz, S:
Univ Barcelona, Hosp Clin Barcelona, Diagnost Image Ctr, Neuroradiol Sect,Radiol Dept, Barcelona, Spain
Bargallo, N:
Univ Barcelona, Hosp Clin Barcelona, Diagnost Image Ctr, Neuroradiol Sect,Radiol Dept, Barcelona, Spain
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Magnet Resonance Image Core Facil, Barcelona, Spain
Ribas, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Arranz, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Torres, S:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Iulita, MF:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Belbin, O:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Camacho, V:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Serv Otorrinolaringol, Barcelona, Spain
Alcolea, D:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Lleo, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fortea, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Bejanin, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, St Pau Memory Unit,Dept Neurol, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBE, Madrid, Spain
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