Examining Gene-Environment Interactions Using Aggregate Scores in a First-Episode Psychosis Cohort
Por:
Mas, S, Boloc, D, Rodriguez, N, Mezquida, G, Amoretti, S, Cuesta, MJ, Gonzalez-Penas, J, Garcia-Alcon, A, Lobo, A, Gonzalez-Pinto, A, Corripio, I, Vieta, E, Castro-Fornieles, J, Mane, A, Saiz-Ruiz, J, Gasso, P, Bioque, M, Bernardo, M
Publicada:
1 jul 2020
Resumen:
Gene-environment (GxE) interactions have been related to psychosis spectrum disorders, involving multiple common genetic variants in multiple genes with very small effect sizes, and several environmental factors that constitute a dense network of exposures named the exposome. Here, we aimed to analyze GxE in a cohort of 310 first-episode psychotic (FEP) and 236 healthy controls, by using aggregate scores estimated in large populations such as the polygenic risk score for schizophrenia and (PRS-SCZ) and the Maudsley environmental risk score (ERS). In contrast to previous findings, in our study, the PRS-SCZ did not discriminate cases from controls, but the ERS score explained a similar percentage of the variance as in other studies using similar approaches. Our study supports a positive additive interaction, indicating synergy between genetic susceptibility to schizophrenia (PRS-SCZ dichotomized according to the highest quartile distribution of the control population) and the exposome (ERS > 75% of the controls). This additive interaction showed genetic and environmental dose dependence. Our study shows that the use of aggregate scores derived from large and powered studies instead of statistics derived from specific sample characteristics is a powerful tool for the study of the effects of GxE on the risk of psychotic spectrum disorders. In conclusion, by using a genetic risk score and an ERS we have provided further evidence for the role of GxE in psychosis.
Filiaciones:
Mas, S:
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
Boloc, D:
Univ Barcelona, Dept Med, Barcelona, Spain
Rodriguez, N:
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
Mezquida, G:
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Barcelona Clin, Neurosci Inst, Schizophrenia Unit, Barcelona, Spain
Amoretti, S:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Barcelona Clin, Neurosci Inst, Schizophrenia Unit, Barcelona, Spain
Cuesta, MJ:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Gonzalez-Penas, J:
Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IiSGM Ctr, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat,Ctr Invest Biome, Madrid, Spain
Garcia-Alcon, A:
Hosp Gen Univ Gregorio Maranon, Inst Invest Sanitaria Gregorio Maranon IiSGM Ctr, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat,Ctr Invest Biome, Madrid, Spain
Lobo, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Zaragoza Univ, Dept Med & Psychiat, Zaragoza, Spain
Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain
Gonzalez-Pinto, A:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Hosp Univ Alava, Dept Psychiat, Vitoria, Spain
BIOARABA Hlth Res Inst, Vitoria, Spain
Univ Basque Country, Vitoria, Spain
Corripio, I:
Hosp Santa Creu & Sant Pau, Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona UAB, Barcelona, Spain
CIBERSAM, Mental Hlth Networking Biomed Res Ctr, Madrid, Spain
Vieta, E:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Barcelona, Spain
Castro-Fornieles, J:
Univ Barcelona, Hosp Clin Barcelona, Clin Inst Neurosci, CIBERSAM,IDIBAPS,Dept Child & Adolescent Psychiat, 2017SGR881, Barcelona, Spain
Mane, A:
Hosp del Mar Med Res Inst IMIM, Barcelona, Spain
Autonomous Univ Barcelona UAB, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Saiz-Ruiz, J:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Univ Alcala De Henares, Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain
Gasso, P:
Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
Bioque, M:
Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
Hosp Clin Barcelona, Barcelona Clin, Neurosci Inst, Schizophrenia Unit, Barcelona, Spain
Bernardo, M:
Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Barcelona Clin, Neurosci Inst, Schizophrenia Unit, Barcelona, Spain
Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain
Green Published, Bronze
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