Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register
Por:
Fernández-Lozano, D, Hernández-Rodríguez, I, Narvaez, J, Domínguez-Alvaro, M, De Miguel, E, Silva-Díaz, M, Belzunegui, JM, Morales, CM, Sánchez, J, Galíndez-Agirregoikoa, E, Aldaroso, V, Abasolo, L, Loricera, J, Garrido-Puñal, N, Alvarado, PM, Larena, C, Navarro, VA, Calvet, J, Casafont-Solé, I, Ortiz-Sanjuán, F, Monte, TCS, Castañeda, S, Blanco, R
Publicada:
1 mar 2024
Resumen:
Objective This study aimed to estimate the incidence of giant cell arteritis (GCA) in Spain and to analyse its clinical manifestations, and distribution by age group, sex, geographical area and season.Methods We included all patients diagnosed with GCA between 1 June 2013 and 29 March 2019 at 26 hospitals of the National Health System. They had to be aged >= 50 years and have at least one positive results in an objective diagnostic test (biopsy or imaging techniques), meet 3/5 of the 1990 American College of Rheumatology classification criteria or have a clinical diagnosis based on the expert opinion of the physician in charge. We calculated incidence rate using Poisson regression and assessed the influence of age, sex, geographical area and season.Results We identified 1675 cases of GCA with a mean age at diagnosis of 76.9 +/- 8.3 years. The annual incidence was estimated at 7.42 (95% CI 6.57 to 8.27) cases of GCA per 100 000 people >= 50 years with a peak for patients aged 80-84 years (23.06 (95% CI 20.89 to 25.4)). The incidence was greater in women (10.06 (95% CI 8.7 to 11.5)) than in men (4.83 (95% CI 3.8 to 5.9)). No significant differences were found between geographical distribution and incidence throughout the year (p=0.125). The phenotypes at diagnosis were cranial in 1091 patients, extracranial in 337 patients and mixed in 170 patients.Conclusions This is the first study to estimate the incidence of GCA in Spain at a national level. We found a predominance among women and during the ninth decade of life with no clear variability according to geographical area or seasons of the year.
Filiaciones:
Fernández-Lozano, D:
Hosp Clin Univ Valencia, Rheumatol, Valencia, Spain
Hernández-Rodríguez, I:
Complexo Hosp Univ Vigo, Rheumatol, Vigo, Spain
Narvaez, J:
Hosp Univ Bellvitge, Rheumatol, Lhospitalet De Llobregat, Spain
Domínguez-Alvaro, M:
Soc Espanola Reumatol, Res Unit, Madrid, Spain
De Miguel, E:
Hosp Univ La Paz, Rheumatol, Madrid, Spain
Silva-Díaz, M:
Complexo Hosp Univ A Coruna, Rheumatol, La Coruna, Spain
Belzunegui, JM:
Hosp Donostia, Rheumatol, San Sebastian, Spain
Morales, CM:
Complejo Asistencial Univ Leon, Rheumatol, Leon, Spain
Sánchez, J:
Hosp Univ 12 Octubre, Rheumatol, Madrid, Spain
Galíndez-Agirregoikoa, E:
Hosp Univ Basurto, Rheumatol, Bilbao, Spain
Aldaroso, V:
Complejo Hosp Navarra, Rheumatol, Pamplona, Spain
Abasolo, L:
Hosp Clin Univ San Carlos, Rheumatol, Madrid, Spain
Hosp Clin San Carlos, Inst Invest Sanitaria, Madrid, Spain
Loricera, J:
Hosp Univ Marques De Valdecilla, Rheumatol, Santander, Spain
IDIVAL, Immunopathol Grp, Santander, Spain
Garrido-Puñal, N:
Hosp Univ Virgen Del Rocio, Rheumatol, Seville, Spain
Alvarado, PM:
Hosp Santa Creu & Sant Pau, Rheumatol, Barcelona, Spain
Larena, C:
Hosp Univ Ramon Y Cajal, Rheumatol, Madrid, Spain
Navarro, VA:
Hosp Moises Broggi, Rheumatol, Barcelona, Spain
Calvet, J:
Parc Tauli Hosp Univ, Inst Invest & Innovac Parc Tauli I3PT CERCA, Rheumatol, Sabadell, Spain
Univ Autonoma Barcelona, Sabadell, Spain
Casafont-Solé, I:
Hosp Germans Trias I Pujol, Rheumatol, Barcelona, Spain
Ortiz-Sanjuán, F:
Hosp Politecn & Univ La Fe, Rheumatol, Valencia, Spain
Monte, TCS:
Hosp Mar, Rheumatol, Barcelona, Spain
Castañeda, S:
Hosp Univ Princesa, Rheumatol, IIS Princesa, Madrid, Spain
Blanco, R:
Hosp Univ Marques De Valdecilla, Rheumatol, Santander, Spain
IDIVAL, Immunopathol Grp, Santander, Spain
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