Cortical Macro- and Microstructural Changes in Parkinson's Disease with Probable Rapid Eye Movement Sleep Behavior Disorder
Por:
Pardo, J, Montal, V, Campabadal, A, Oltra, J, Uribe, C, Roura, I, Bargalló, N, Martí, MJ, Compta, Y, Iranzo, A, Fortea, J, Junqué, C, Segura, B
Publicada:
8 mar 2024
Ahead of Print:
1 mar 2024
Resumen:
Background: Evidence regarding cortical atrophy patterns in Parkinson's disease (PD) with probable rapid eye movement sleep behavior disorder (RBD) (PD-pRBD) remains scarce. Cortical mean diffusivity (cMD), as a novel imaging biomarker highly sensitive to detecting cortical microstructural changes in different neurodegenerative diseases, has not been investigated in PD-pRBD yet. Objectives: The aim was to investigate cMD as a sensitive measure to identify subtle cortical microstructural changes in PD-pRBD and its relationship with cortical thickness (CTh). Methods: Twenty-two PD-pRBD, 31 PD without probable RBD (PD-nonpRBD), and 28 healthy controls (HC) were assessed using 3D T1-weighted and diffusion-weighted magnetic resonance imaging on a 3-T scanner and neuropsychological testing. Measures of cortical brain changes were obtained through cMD and CTh. Two-class group comparisons of a general linear model were performed (P < 0.05). Cohen's d effect size for both approaches was computed. Results: PD-pRBD patients showed higher cMD than PD-nonpRBD patients in the left superior temporal, superior frontal, and precentral gyri, precuneus cortex, as well as in the right middle frontal and postcentral gyri and paracentral lobule (d > 0.8), whereas CTh did not detect significant differences. PD-pRBD patients also showed increased bilateral posterior cMD in comparison with HCs (d > 0.8). These results partially overlapped with CTh results (0.5 < d < 0.8). PD-nonpRBD patients showed no differences in cMD when compared with HCs but showed cortical thinning in the left fusiform gyrus and lateral occipital cortex bilaterally (d > 0.5). Conclusions: cMD may be more sensitive than CTh displaying significant cortico-structural differences between PD subgroups, indicating this imaging biomarker's utility in studying early cortical changes in PD. (c) 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Filiaciones:
Pardo, J:
Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Spain
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Montal, V:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Dept Neurol, Barcelona, Spain
Barcelona Supercomp Ctr, Dept Life Sci, Barcelona, Spain
Campabadal, A:
Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Spain
Consorci Corp Sanitaria Parc Tauli De Sabadell, Neurol Serv, Barcelona, Spain
Oltra, J:
Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Spain
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Uribe, C:
Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Spain
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Campbell Family Mental Hlth Res Inst, Brain Hlth Imaging Ctr, Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada
Roura, I:
Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Spain
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Bargalló, N:
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Hosp Clin Univ Barcelona, Imaging Diagnost Ctr CDI, Barcelona, Spain
Martí, MJ:
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Univ Barcelona, Hosp Clin Univ Barcelona, UBNeuro Inst Neurosci, Parkinsons Dis & Movement Disorders Unit, Barcelona, Spain
Compta, Y:
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Univ Barcelona, Hosp Clin Univ Barcelona, UBNeuro Inst Neurosci, Parkinsons Dis & Movement Disorders Unit, Barcelona, Spain
Iranzo, A:
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Univ Barcelona, Hosp Clin Univ Barcelona, Sleep Disorders Ctr, Neurol Serv, Barcelona, Spain
Fortea, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Dept Neurol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Fdn Catalana Sindrome Down, Barcelona Med Ctr, Barcelona, Spain
Junqué, C:
Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Spain
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Segura, B:
Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, Barcelona, Spain
Inst Invest Biomed August Pi I Sunyer IDIBAPS, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Dept Med, Med Psychol Unit, C Casanova 143, Barcelona 08036, Catalonia, Spain
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