Cortical microinfarcts in adults with Down syndrome assessed with 3T-MRI
Por:
Aranha, MR, Montal, V, van den Brink, H, Pegueroles, J, Carmona-Iragui, M, Videla, L, Blesa, LM, Benejam, B, Arranz, J, Valldeneu, S, Barroeta, I, Fernández, S, Ribas, L, Alcolea, D, González-Ortiz, S, Bargalló, N, Biessels, GJ, Blesa, R, Lleó, A, Coutinho, AM, Leite, CC, Bejanin, A, Fortea, J
Publicada:
21 abr 2024
Ahead of Print:
1 abr 2024
Resumen:
BACKGROUNDCortical microinfarcts (CMI) were attributed to cerebrovascular disease and cerebral amyloid angiopathy (CAA). CAA is frequent in Down syndrome (DS) while hypertension is rare, yet no studies have assessed CMI in DS.METHODSWe included 195 adults with DS, 63 with symptomatic sporadic Alzheimer's disease (AD), and 106 controls with 3T magnetic resonance imaging. We assessed CMI prevalence in each group and CMI association with age, AD clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition in DS.RESULTSCMI prevalence was 11.8% in DS, 4.7% in controls, and 17.5% in sporadic AD. In DS, CMI increased in prevalence with age and the AD clinical continuum, was clustered in the parietal lobes, and was associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions.DISCUSSIONIn DS, CMI are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic CAA phenotype.Highlights This is the first study to assess cortical microinfarcts (assessed with 3T magnetic resonance imaging) in adults with Down syndrome (DS). We studied the prevalence of cortical microinfarcts in DS and its relationship with age, the Alzheimer's disease (AD) clinical continuum, vascular risk factors, vascular neuroimaging findings, amyloid/tau/neurodegeneration biomarkers, and cognition. The prevalence of cortical microinfarcts was 11.8% in DS and increased with age and along the AD clinical continuum. Cortical microinfarcts were clustered in the parietal lobes, and were associated with lacunes and cortico-subcortical infarcts, but not hemorrhagic lesions. In DS, cortical microinfarcts are posteriorly distributed and related to ischemic but not hemorrhagic findings suggesting they might be associated with a specific ischemic phenotype of cerebral amyloid angiopathy.
Filiaciones:
Aranha, MR:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Univ Sao Paulo, Fac Med FMUSP, Dept Radiol & Oncol, Lab Nucl Med LIM 43,Hosp Clin HCFMUSP, Sao Paulo, Brazil
Univ Sao Paulo, Hosp Clin HCFMUSP, Dept Radiol & Oncol, Fac Med,Lab Magnet Resonance Neuroradiol LIM 44, Sao Paulo, Brazil
Montal, V:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Barcelona Supercomp Ctr, Placa Eusebi Guell, Barcelona, Spain
van den Brink, H:
Univ Med Ctr Utrecht, Brain Ctr, Dept Neurol & Neurosurg, Utrecht, Netherlands
Pegueroles, J:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Carmona-Iragui, M:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Videla, L:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Blesa, LM:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Benejam, B:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Arranz, J:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Valldeneu, S:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Barroeta, I:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Fernández, S:
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Ribas, L:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Alcolea, D:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
González-Ortiz, S:
Hosp del Mar, Parc Salut Mar, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Diagnost Image Ctr, Neuroradiol Sect,Radiol Dept, Barcelona, Spain
Bargalló, N:
Univ Barcelona, Hosp Clin Barcelona, Diagnost Image Ctr, Neuroradiol Sect,Radiol Dept, Barcelona, Spain
Univ Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Magnet Resonance Image Facil, Barcelona, Spain
Biessels, GJ:
Univ Med Ctr Utrecht, Brain Ctr, Dept Neurol & Neurosurg, Utrecht, Netherlands
Blesa, R:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Lleó, A:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Coutinho, AM:
Univ Sao Paulo, Fac Med FMUSP, Dept Radiol & Oncol, Lab Nucl Med LIM 43,Hosp Clin HCFMUSP, Sao Paulo, Brazil
Leite, CC:
Univ Sao Paulo, Hosp Clin HCFMUSP, Dept Radiol & Oncol, Fac Med,Lab Magnet Resonance Neuroradiol LIM 44, Sao Paulo, Brazil
Bejanin, A:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Fortea, J:
Inst Invest Biomed St Pau IIB St PAU, St Pau Memory Unit, Barcelona, Spain
Ctr Biomed Invest Network Neurodegenerat Dis CIBER, Barcelona, Spain
Fundacio Catalana Sindrome, Barcelona Med Ctr, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Neurol Dept, St Antoni Ma Claret 167, Barcelona 08025, Spain
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