Vaccinated COVID-19 Index Cases Are Less Likely to Transmit SARS-CoV-2 to Their Household Contacts: A Cohort Study
Por:
Godoy, P, Martínez-Baz, I, Parron, I, García-Cenoz, M, Ferras, J, Carol, M, Bes, N, Guillaumes, M, Godoy, S, Toledo, D, Follia, N, Miret, C, Pardos, J, Alsedà, M, Plans-Rubio, P, Sanz, I, Sala, MR, Caylà, JA, Mendioroz, J, Muñoz-Almagro, C, Castilla, J, Domínguez, A
Publicada:
1 mar 2024
Resumen:
The aim of this study was to evaluate the impact of index case vaccination on SARS-CoV-2 transmission to household contacts. In our epidemiological cohort study (May 2022-November 2023), we surveyed registered index case vaccination status and test results for contacts (testing on day 0, and on day 7 for negative contacts) and calculated the secondary attack rate (SAR), i.e., newly infected contacts/susceptible included contacts. The association of the independent variable, index case COVID-19 vaccination (yes/no), with household contact infection was determined using the adjusted odds ratio (aOR) and its 95% confidence interval (CI). We recorded 181 index cases and 314 contacts, of whom 250 agreed to participate; 16 contacts were excluded upon testing positive on day 0. Of the 234 included contacts, 49.1% were women, and the mean (SD) age was 51.9 (19.8) years. The overall SAR of 37.2% (87/234) was lower in the contacts of both vaccinated index cases (34.9% vs. 63.2%; p = 0.014) and index cases with a previous SARS-CoV-2 infection history (27.0% vs. 46.3%; p = 0.002). Index case vaccination showed a protective effect against infection for their household contacts (aOR = 0.21; 95% CI: 0.07, 0.67). The household SAR was high when the Omicron variant circulated. Vaccinated index cases were less likely to transmit SARS-CoV-2 to their contacts.
Filiaciones:
Godoy, P:
Univ Lleida, Inst Recerca Biomed IRB Lleida, Lleida 25006, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Martínez-Baz, I:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Inst Salud Publ Navarra IdiSNA, Pamplona 31008, Spain
Parron, I:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
García-Cenoz, M:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Inst Salud Publ Navarra IdiSNA, Pamplona 31008, Spain
Ferras, J:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Carol, M:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Bes, N:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Guillaumes, M:
Agencia Salut Publ Barcelona, Barcelona 08023, Spain
Godoy, S:
Univ Lleida, Inst Recerca Biomed IRB Lleida, Lleida 25006, Spain
ICS, Lleida 08007, Spain
Toledo, D:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Univ Barcelona, Dept Med, Barcelona 08036, Spain
Follia, N:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Miret, C:
Univ Lleida, Inst Recerca Biomed IRB Lleida, Lleida 25006, Spain
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Pardos, J:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Alsedà, M:
Univ Lleida, Inst Recerca Biomed IRB Lleida, Lleida 25006, Spain
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Plans-Rubio, P:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Sanz, I:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Sala, MR:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Caylà, JA:
Barcelona TB Res Unit Fdn, Barcelona 08008, Spain
Mendioroz, J:
Agencia Salut Publ Catalunya, Barcelona 08005, Spain
Muñoz-Almagro, C:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Hosp St Joan Deu, Lab Microbiol, Barcelona 08950, Spain
Castilla, J:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Inst Salud Publ Navarra IdiSNA, Pamplona 31008, Spain
Domínguez, A:
CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Univ Barcelona, Dept Med, Barcelona 08036, Spain
Green Published, gold
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