Staging Parkinson's disease according to the MNCD classification correlates with caregiver burden
Por:
Santos-García, D, Fonticoba, TD, Bartolomé, CC, Painceiras, MJF, Díaz, IG, Alvarado, MCI, Paz, JM, Jesús, S, Cosgaya, M, Caldentey, JG, Caballol, N, Legarda, I, Vara, JH, Cabo, I, Manzanares, LL, Aramburu, IG, Rivera, MAA, Mayordomo, VG, Nogueira, V, García-Soto, JD, Borrué, C, Vila, BS, Sauco, MA, Vela, L, Escalante, S, Cubo, E, Mendoza, Z, Castrillo, JCM, Alonso, PS, Losada, MGA, Ariztegui, NL, Gastón, I, Kulisevsky, J, Seijo, M, Valero, C, Redondo, RA, Buongiorno, MT, Ordás, C, Menéndez-González, M, Mcafee, D, Martinez-Martin, P, Mir, P, COPPADIS Study Grp
Publicada:
8 nov 2023
Ahead of Print:
1 nov 2023
Resumen:
Background and objective: Recently, we demonstrated that staging Parkinson's disease (PD) with a novel simple classification called MNCD, based on four axes (motor, non-motor, cognition, and dependency) and five stages, correlated with disease severity and patients' quality of life. Here, we analyzed the correlation of MNCD staging with PD caregiver's status.Patients and methods: Data from the baseline visit of PD patients and their principal caregiver recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD total score (from 0 to 12) and MNCD stages (from 1 to 5) in this cross-sectional analysis. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), PQ-10, and EUROHIS-QOL 8-item index (EUROHIS-QOL8).Results: Two hundred and twenty-four PD patients (63 +/- 9.6 years old; 61.2% males) and their caregivers (58.5 +/- 12.1 years old; 67.9% females) were included. The frequency of MNCD stages was 1, 7.6%; 2, 58.9%; 3, 31.3%; and 4-5, 2.2%. A more advanced MNCD stage was associated with a higher score on the ZCBI (p < .0001) and CSI (p < .0001), and a lower score on the PQ-10 (p = .001), but no significant differences were observed in the BDI-II (p = .310) and EUROHIS-QOL8 (p = .133). Moderate correlations were observed between the MNCD total score and the ZCBI (r = .496; p < .0001), CSI (r = .433; p < .0001), and BDI-II (r = .306; p < .0001) in caregivers.Conclusion: Staging PD according to the MNCD classification is correlated with caregivers' strain and burden.
Filiaciones:
Santos-García, D:
Complejo Hosp Univ Coruna, CHUAC, Dept Neurol, La Coruna, Spain
Complejo Hosp Univ Coruna CHUAC, Hosp Univ Coruna HUAC, Dept Neurol, C As Xubias 84, La Coruna 15006, Spain
Fonticoba, TD:
Complejo Hosp Univ Ferrol, CHUF, Dept Neurol, La Coruna, Spain
Bartolomé, CC:
Complejo Hosp Univ Coruna, CHUAC, Dept Neurol, La Coruna, Spain
Painceiras, MJF:
Complejo Hosp Univ Coruna, CHUAC, Dept Neurol, La Coruna, Spain
Díaz, IG:
Complejo Hosp Univ Coruna, CHUAC, Dept Neurol, La Coruna, Spain
Alvarado, MCI:
Complejo Hosp Univ Coruna, CHUAC, Dept Neurol, La Coruna, Spain
Paz, JM:
Complejo Hosp Univ Coruna, CHUAC, Dept Neurol, La Coruna, Spain
Jesús, S:
Univ Seville, Hosp Univ Virgen Rocio, Dept Neurol,Inst Biomed Sevilla,CSIC, Unidad Trastornos Movimiento,Serv Neurol & Neurofi, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Cosgaya, M:
Hosp Clin Barcelona, Dept Neurol, Barcelona, Spain
Caldentey, JG:
Ctr Neurol Oms 42, Dept Neurol, Palma De Mallorca, Spain
Caballol, N:
Hosp Moises Broggi St Joan Despi, Dept Neurol, Consorci Sanit Integral, Barcelona, Spain
Legarda, I:
Hosp Univ Son Espases, Dept Neurol, Palma De Mallorca, Spain
Vara, JH:
Hosp Univ Bellvitge, Neurol Dept, Barcelona, Spain
Cabo, I:
Complejo Hosp Univ Pontevedra CHOP, Dept Neurol, Pontevedra, Spain
Manzanares, LL:
Hosp Univ La Princesa, Dept Neurol, Madrid, Spain
Aramburu, IG:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Hosp Univ Marques Valdecilla, IDIVAL, Dept Neurol, Santander, Spain
Rivera, MAA:
Hosp Gen LHospitalet, Dept Neurol, Consorci Sanit Integral, LHospitalet Llobregat, Barcelona, Spain
Mayordomo, VG:
Vithas Madrid Milagrosa Univ Hosp, Vithas Hosp Grp, Inst Neurosci, Dept Neurol, Madrid, Spain
Nogueira, V:
Hosp Univ Lucus Augusti, Dept Neurol, Lugo, Spain
García-Soto, JD:
Hosp Univ Virgen Macarena, Dept Neurol, Seville, Spain
Borrué, C:
Hosp Infanta Sofia, Dept Neurol, Madrid, Spain
Vila, BS:
Inst Assistencia Sanit IAS, Inst Catala Salut, Dept Neurol, Girona, Spain
Sauco, MA:
Hosp Gen Univ Elche, Dept Neurol, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Dept Neurol, Madrid, Spain
Escalante, S:
Hosp Tortosa Verge Cinta HTVC, Dept Neurol, Tortosa, Tarragona, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Dept Neurol, Burgos, Spain
Mendoza, Z:
Hosp Univ Canarias, Dept Neurol, San Cristobal Laguna, Santa Cruz De Tenerife, Spain
Castrillo, JCM:
Hosp Univ Ramon & Cajal, IRYCIS, Dept Neurol, Madrid, Spain
Alonso, PS:
Hosp Univ Puerta Hierro, Dept Neurol, Madrid, Spain
Losada, MGA:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Dept Neurol, Vigo, Spain
Ariztegui, NL:
Complejo Hosp Toledo, Dept Neurol, Toledo, Spain
Gastón, I:
Complejo Hosp Navarra, Dept Neurol, Pamplona, Spain
Kulisevsky, J:
Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona, Spain
Valero, C:
Hosp Arnau Vilanova, Dept Neurol, Valencia, Spain
Redondo, RA:
Hosp Univ Lucus Augusti, Dept Neurol, Lugo, Spain
Buongiorno, MT:
Hosp Univ Mutua Terrassa, Dept Neurol, Terrassa, Barcelona, Spain
Ordás, C:
Hosp Rey Juan Carlos, Dept Neurol, Madrid, Spain
Menéndez-González, M:
Hosp Univ Cent Asturias, Dept Neurol, Oviedo, Spain
Mcafee, D:
Univ Maryland, Sch Med, Baltimore, MD USA
Martinez-Martin, P:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Mir, P:
Univ Seville, Hosp Univ Virgen Rocio, Dept Neurol,Inst Biomed Sevilla,CSIC, Unidad Trastornos Movimiento,Serv Neurol & Neurofi, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Green Accepted, gold
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