Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression
Por:
Argyelan, M, Deng, ZD, Ousdal, OT, Oltedal, L, Angulo, B, Baradits, M, Spitzberg, AJ, Kessler, U, Sartorius, A, Dols, A, Narr, KL, Espinoza, R, van Waarde, JA, Tendolkar, I, van Eijndhoven, P, van Wingen, GA, Takamiya, A, Kishimoto, T, Jorgensen, MB, Jorgensen, A, Paulson, OB, Yrondi, A, Péran, P, Soriano-Mas, C, Cardoner, N, Cano, M, van Diermen, L, Schrijvers, D, Belge, JB, Emsell, L, Bouckaert, F, Vandenbulcke, M, Kiebs, M, Hurlemann, R, Mulders, PCR, Redlich, R, Dannlowski, U, Erhan, K, Kritzer, MD, Ellard, KK, Camprodon, JA, Petrides, G, Malhotra, AK, Abbott, CC
Publicada:
1 feb 2024
Ahead of Print:
1 nov 2023
Resumen:
Neurostimulation is a mainstream treatment option for major depression. Neuromodulation techniques apply repetitive magnetic or electrical stimulation to some neural target but significantly differ in their invasiveness, spatial selectivity, mechanism of action, and efficacy. Despite these differences, recent analyses of transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS)-treated individuals converged on a common neural network that might have a causal role in treatment response. We set out to investigate if the neuronal underpinnings of electroconvulsive therapy (ECT) are similarly associated with this causal depression network (CDN). Our aim here is to provide a comprehensive analysis in three cohorts of patients segregated by electrode placement (N = 246 with right unilateral, 79 with bitemporal, and 61 with mixed) who underwent ECT. We conducted a data-driven, unsupervised multivariate neuroimaging analysis Principal Component Analysis (PCA) of the cortical and subcortical volume changes and electric field (EF) distribution to explore changes within the CDN associated with antidepressant outcomes. Despite the different treatment modalities (ECT vs TMS and DBS) and methodological approaches (structural vs functional networks), we found a highly similar pattern of change within the CDN in the three cohorts of patients (spatial similarity across 85 regions: r = 0.65, 0.58, 0.40, df = 83). Most importantly, the expression of this pattern correlated with clinical outcomes (t = -2.35, p = 0.019). This evidence further supports that treatment interventions converge on a CDN in depression. Optimizing modulation of this network could serve to improve the outcome of neurostimulation in depression.
Filiaciones:
Argyelan, M:
Inst Behav Sci, Feinstein Inst Med Res, Manhasset, NY USA
Zucker Hillside Hosp, Glen Oaks, NY 11004 USA
Deng, ZD:
NIMH, Noninvas Neuromodulat Unit, Expt Therapeut & Pathophysiol Branch, NIH, Bethesda, MD USA
Duke Univ, Sch Med, Dept Psychiat & Behav Sci, Durham, NC USA
Ousdal, OT:
Univ Bergen, Fac Med, Dept Biomed, Bergen, Norway
Haukeland Hosp, Dept Radiol, Bergen, Norway
Oltedal, L:
Univ Bergen, Dept Clin Med, Bergen, Norway
Haukeland Hosp, Mohn Med Imaging & Visualizat Ctr, Dept Radiol, Bergen, Norway
Angulo, B:
Inst Behav Sci, Feinstein Inst Med Res, Manhasset, NY USA
Baradits, M:
Semmelweis Univ, Dept Psychiat & Psychotherapy, Budapest, Hungary
Spitzberg, AJ:
Zucker Hillside Hosp, Glen Oaks, NY 11004 USA
Kessler, U:
Univ Bergen, Haukeland Univ Hosp, Dept Psychiat, Bergen, Norway
Sartorius, A:
Heidelberg Univ, Cent Inst Mental Hlth CIMH, Med Fac Mannheim, Dept Psychiat & Psychotherapy, Heidelberg, Germany
Dols, A:
Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Psychiat, Utrecht, Netherlands
Amsterdam UMC Locat Vrije Univ Amsterdam, Psychiat, Neurosci, Amsterdam, Netherlands
Narr, KL:
Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA USA
Espinoza, R:
Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA
van Waarde, JA:
Rijnstate, Arnhem, Netherlands
Tendolkar, I:
Donders Inst Brain Cognit & Behav, Dept Psychiat, Nijmegen, Netherlands
van Eijndhoven, P:
Donders Inst Brain Cognit & Behav, Dept Psychiat, Nijmegen, Netherlands
van Wingen, GA:
Amsterdam UMC Locat Univ Amsterdam, Dept Psychiat, Amsterdam, Netherlands
Amsterdam Neurosci, Amsterdam, Netherlands
Takamiya, A:
Keio Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan
Katholieke Univ Leuven, Leuven Brain Inst, Dept Neurosci, Neuropsychiat, Leuven, Belgium
Kishimoto, T:
Keio Univ, Sch Med, Hills Joint Res Lab Future Prevent Med & Wellness, Tokyo, Japan
Jorgensen, MB:
Univ Copenhagen, Psychiat Ctr Copenhagen, Copenhagen, Denmark
Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
Jorgensen, A:
Univ Copenhagen, Psychiat Ctr Copenhagen, Copenhagen, Denmark
Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
Paulson, OB:
Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark
Univ Copenhagen, Neurobiol Res Unit, Rigshosp, Copenhagen, Denmark
Yrondi, A:
Univ Toulouse, Ctr Expert Depress Resistante, Serv Psychiat & Psychol Med, Fdn Fondamental,CHU Toulouse,ToNIC,Toulouse NeuroI, Toulouse, France
Péran, P:
Univ Toulouse, Toulouse NeuroImaging Ctr, ToNIC, Inserm,UPS, Toulouse, France
Soriano-Mas, C:
Univ Barcelona UB, Dept Social Psychol & Quantitat Psychol, Barcelona, Spain
Bellvitge Univ Hosp, Bellvitge Biomed Res Inst, Dept Psychiat, IDIBELL, Barcelona, Spain
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Cardoner, N:
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, St Pau Mental Hlth Res Grp, Barcelona, Spain
Univ Autonoma Barcelona, Sch Med Bellaterra, Dept Psychiat & Forens Med, Barcelona, Spain
Cano, M:
Carlos III Hlth Inst, CIBERSAM, Madrid, Spain
Hosp Santa Creu & Sant Pau, Inst Invest Biomed St Pau IIB St Pau, St Pau Mental Hlth Res Grp, Barcelona, Spain
van Diermen, L:
Univ Antwerp, Collaborat Antwerp Psychiat Res Inst CAPRI, Fac Med & Hlth Sci, Dept Psychiat, Antwerp, Belgium
Psychiat Ctr Bethanie, Andreas Vesaliuslaan 39, B-2980 Zoersel, Belgium
Schrijvers, D:
Univ Antwerp, Collaborat Antwerp Psychiat Res Inst CAPRI, Fac Med & Hlth Sci, Dept Psychiat, Antwerp, Belgium
Univ Psychiat Ctr Duffel, Dept Psychiat, Stn Str 22, B-2570 Duffel, Belgium
Belge, JB:
Univ Antwerp, Collaborat Antwerp Psychiat Res Inst CAPRI, Fac Med & Hlth Sci, Dept Psychiat, Antwerp, Belgium
Radboud Univ Nijmegen, Dept Psychiat, Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands
Emsell, L:
Katholieke Univ Leuven, Geriatr Psychiat, Univ Psychiat Ctr, Leuven, Belgium
Bouckaert, F:
Katholieke Univ Leuven, Geriatr Psychiat, Univ Psychiat Ctr, Leuven, Belgium
Vandenbulcke, M:
Katholieke Univ Leuven, Geriatr Psychiat, Univ Psychiat Ctr, Leuven, Belgium
Kiebs, M:
Univ Hosp Oldenburg, Sch Med & Hlth Sci, Oldenburg, Germany
Univ Hosp Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany
Hurlemann, R:
Univ Hosp Oldenburg, Sch Med & Hlth Sci, Oldenburg, Germany
Mulders, PCR:
Donders Inst Brain Cognit & Behav, Dept Psychiat, Nijmegen, Netherlands
Redlich, R:
Univ Halle, Dept Psychol, Halle, Germany
German Ctr Mental Hlth DZPG, Site Jena Magdeburg Halle, Halle, Germany
Dannlowski, U:
Univ Munster, Dept Translat Psychiat, Munster, Germany
Erhan, K:
Univ Munster, Dept Mental Hlth, Munster, Germany
Kritzer, MD:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA
Ellard, KK:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA
Camprodon, JA:
Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA
Petrides, G:
Zucker Hillside Hosp, Glen Oaks, NY 11004 USA
Malhotra, AK:
Inst Behav Sci, Feinstein Inst Med Res, Manhasset, NY USA
Zucker Hillside Hosp, Glen Oaks, NY 11004 USA
Abbott, CC:
Univ New Mexico, Dept Psychiat, Albuquerque, NM USA
Green Published, hybrid, All Open Access; Green Open Access; Hybrid Gold Open Access
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