Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.
Por:
Tobias DK, Merino J, Ahmad A, Aiken C, Benham JL, Bodhini D, Clark AL, Colclough K, Corcoy R, Cromer SJ, Duan D, Felton JL, Francis EC, Gillard P, Gingras V, Gaillard R, Haider E, Hughes A, Ikle JM, Jacobsen LM, Kahkoska AR, Kettunen JLT, Kreienkamp RJ, Lim LL, Männistö JME, Massey R, Mclennan NM, Miller RG, Morieri ML, Most J, Naylor RN, Ozkan B, Patel KA, Pilla SJ, Prystupa K, Raghavan S, Rooney MR, Schön M, Semnani-Azad Z, Sevilla-Gonzalez M, Svalastoga P, Takele WW, Tam CH, Thuesen ACB, Tosur M, Wallace AS, Wang CC, Wong JJ, Yamamoto JM, Young K, Amouyal C, Andersen MK, Bonham MP, Chen M, Cheng F, Chikowore T, Chivers SC, Clemmensen C, Dabelea D, Dawed AY, Deutsch AJ, Dickens LT, DiMeglio LA, Dudenhöffer-Pfeifer M, Evans-Molina C, Fernández-Balsells MM, Fitipaldi H, Fitzpatrick SL, Gitelman SE, Goodarzi MO, Grieger JA, Guasch-Ferré M, Habibi N, Hansen T, Huang C, Harris-Kawano A, Ismail HM, Hoag B, Johnson RK, Jones AG, Koivula RW, Leong A, Leung GKW, Libman IM, Liu K, Long SA, Lowe WL Jr, Morton RW, Motala AA, Onengut-Gumuscu S, Pankow JS, Pathirana M, Pazmino S, Perez D, Petrie JR, Powe CE, Quinteros A, Jain R, Ray D, Ried-Larsen M, Saeed Z, Santhakumar V, Kanbour S, Sarkar S, Monaco GSF, Scholtens DM, Selvin E, Sheu WH, Speake C, Stanislawski MA, Steenackers N, Steck AK, Stefan N, Støy J, Taylor R, Tye SC, Ukke GG, Urazbayeva M, Van der Schueren B, Vatier C, Wentworth JM, Hannah W, White SL, Yu G, Zhang Y, Zhou SJ, Beltrand J, Polak M, Aukrust I, de Franco E, Flanagan SE, Maloney KA, McGovern A, Molnes J, Nakabuye M, Njølstad PR, Pomares-Millan H, Provenzano M, Saint-Martin C, Zhang C, Zhu Y, Auh S, de Souza R, Fawcett AJ, Gruber C, Mekonnen EG, Mixter E, Sherifali D, Eckel RH, Nolan JJ, Philipson LH, Brown RJ, Billings LK, Boyle K, Costacou T, Dennis JM, Florez JC, Gloyn AL, Gomez MF, Gottlieb PA, Greeley SAW, Griffin K, Hattersley AT, Hirsch IB, Hivert MF, Hood KK, Josefson JL, Kwak SH, Laffel LM, Lim SS, Loos RJF, Ma RCW, Mathieu C, Mathioudakis N, Meigs JB, Misra S, Mohan V, Murphy R, Oram R, Owen KR, Ozanne SE, Pearson ER, Perng W, Pollin TI, Pop-Busui R, Pratley RE, Redman LM, Redondo MJ, Reynolds RM, Semple RK, Sherr JL, Sims EK, Sweeting A, Tuomi T, Udler MS, Vesco KK, Vilsbøll T, Wagner R, Rich SS, Franks PW
Publicada:
5 oct 2023
Ahead of Print:
5 oct 2023
Resumen:
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
Filiaciones:
Tobias DK:
Division of Preventative Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Merino J:
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Ahmad A:
Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Aiken C:
Department of Obstetrics and Gynaecology, The Rosie Hospital, Cambridge, UK
NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK
Benham JL:
Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Bodhini D:
Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India
Clark AL:
Division of Pediatric Endocrinology, Department of Pediatrics, Saint Louis University School of Medicine, SSM Health Cardinal Glennon Children's Hospital, St. Louis, MO, USA
Colclough K:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Corcoy R:
CIBER-BBN, ISCIII, Madrid, Spain
Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain
Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain
Cromer SJ:
Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA
Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
Department of Medicine, Harvard Medical School, Boston, MA, USA
Duan D:
Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Felton JL:
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
Francis EC:
Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA
Gillard P:
University Hospital Leuven, Leuven, Belgium
Gingras V:
Department of Nutrition, Université de Montréal, Montreal, Quebec, Quebec, Canada
Research Center, Sainte-Justine University Hospital Center, Montreal, Quebec, Quebec, Canada
Gaillard R:
Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands
Haider E:
Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK
Hughes A:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Ikle JM:
Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA
Stanford Diabetes Research Center, Stanford School of Medicine, Stanford University, Stanford, CA, USA
Jacobsen LM:
University of Florida, Gainesville, FL, USA
Kahkoska AR:
Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Kettunen JLT:
Helsinki University Hospital, Abdominal Centre/Endocrinology, Helsinki, Finland
Folkhälsan Research Center, Helsinki, Finland
Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
Kreienkamp RJ:
Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA
Lim LL:
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Asia Diabetes Foundation, Hong Kong SAR, China
Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China
Männistö JME:
Departments of Pediatrics and Clinical Genetics, Kuopio University Hospital, Kuopio, Finland
Department of Medicine, University of Eastern Finland, Kuopio, Finland
Massey R:
Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK
Mclennan NM:
Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK
Miller RG:
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
Morieri ML:
Metabolic Disease Unit, University Hospital of Padova, Padova, Italy
Department of Medicine, University of Padova, Padova, Italy
Most J:
Department of Orthopedics, Zuyderland Medical Center, Sittard-Geleen, The Netherlands
Naylor RN:
Departments of Pediatrics and Medicine, University of Chicago, Chicago, IL, USA
Ozkan B:
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine, Baltimore, MD, USA
Patel KA:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Pilla SJ:
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Department of Health Policy and Management, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA
Prystupa K:
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany
Raghavan S:
Section of Academic Primary Care, US Department of Veterans Affairs Eastern Colorado Health Care System, Aurora, CO, USA
Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA
Rooney MR:
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Schön M:
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany
Institute of Diabetes Research and Metabolic Diseases (IDM), Helmholtz Center Munich, Neuherberg, Germany
Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia
Semnani-Azad Z:
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Sevilla-Gonzalez M:
Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
Department of Medicine, Harvard Medical School, Boston, MA, USA
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA
Svalastoga P:
Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway
Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway
Takele WW:
Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia
Tam CH:
Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China
Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China
Thuesen ACB:
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Tosur M:
Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
Division of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Houston, TX, USA
Children's Nutrition Research Center, USDA/ARS, Houston, TX, USA
Wallace AS:
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Wang CC:
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Wong JJ:
Stanford University School of Medicine, Stanford, CA, USA
Yamamoto JM:
Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Young K:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Amouyal C:
Department of Diabetology, APHP, Paris, France
Sorbonne Université, INSERM, NutriOmic team, Paris, France
Andersen MK:
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Bonham MP:
Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia
Chen M:
Monash Centre for Health Research and Implementation, Monash University, Clayton, Victoria, Australia
Cheng F:
Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China
Chikowore T:
Department of Medicine, Harvard Medical School, Boston, MA, USA
MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA
Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Chivers SC:
Department of Women and Children's Health, King's College London, London, UK
Clemmensen C:
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Dabelea D:
Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Dawed AY:
Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK
Deutsch AJ:
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
Department of Medicine, Harvard Medical School, Boston, MA, USA
Dickens LT:
Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Kovler Diabetes Center, University of Chicago, Chicago, IL, USA
DiMeglio LA:
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
Dudenhöffer-Pfeifer M:
Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Evans-Molina C:
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
Richard L. Roudebush VAMC, Indianapolis, IN, USA
Fernández-Balsells MM:
Biomedical Research Institute Girona, IdIBGi, Girona, Spain
Diabetes, Endocrinology and Nutrition Unit Girona, University Hospital Dr Josep Trueta, Girona, Spain
Fitipaldi H:
Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Fitzpatrick SL:
Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA
Gitelman SE:
University of California at San Francisco, Department of Pediatrics, Diabetes Center, San Francisco, CA, USA
Goodarzi MO:
Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Grieger JA:
Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia
Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia
Guasch-Ferré M:
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
Department of Public Health and Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Habibi N:
Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia
Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia
Hansen T:
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Huang C:
Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China
Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
Harris-Kawano A:
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
Ismail HM:
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
Hoag B:
Division of Endocrinology and Diabetes, Department of Pediatrics, Sanford Children's Hospital, Sioux Falls, SD, USA
University of South Dakota School of Medicine, E Clark St, Vermillion, SD, USA
Johnson RK:
Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA
Jones AG:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK
Koivula RW:
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
Leong A:
Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA
Department of Medicine, Harvard Medical School, Boston, MA, USA
Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA
Leung GKW:
Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia
Libman IM:
UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA
Liu K:
Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia
Long SA:
Center for Translational Immunology, Benaroya Research Institute, Seattle, WA, USA
Lowe WL Jr:
Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Morton RW:
Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Population Health Research Institute, Hamilton, Ontario, Canada
Department of Translational Medicine, Medical Science, Novo Nordisk Foundation, Hellerup, Denmark
Motala AA:
Department of Diabetes and Endocrinology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa
Onengut-Gumuscu S:
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA
Pankow JS:
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Pathirana M:
Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia
Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia
Pazmino S:
Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinologyó, KU Leuven, Leuven, Belgium
Perez D:
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
Petrie JR:
School of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK
Powe CE:
Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA
Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
Department of Medicine, Harvard Medical School, Boston, MA, USA
Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Quinteros A:
Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia
Jain R:
Sanford Children's Specialty Clinic, Sioux Falls, SD, USA
Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA
Ray D:
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Ried-Larsen M:
Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark
Institute for Sports and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
Saeed Z:
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Indiana University School of Medicine, Indianapolis, IN, USA
Santhakumar V:
Division of Preventative Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Kanbour S:
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
AMAN Hospital, Doha, Qatar
Sarkar S:
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Monaco GSF:
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
Scholtens DM:
Department of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Selvin E:
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Sheu WH:
Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan
Divsion of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan
Division of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei, Taiwan
Speake C:
Center for Interventional Immunology, Benaroya Research Institute, Seattle, WA, USA
Stanislawski MA:
Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Steenackers N:
Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinologyó, KU Leuven, Leuven, Belgium
Steck AK:
Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Stefan N:
German Center for Diabetes Research (DZD), Neuherberg, Germany
Institute of Diabetes Research and Metabolic Diseases (IDM), Helmholtz Center Munich, Neuherberg, Germany
University Hospital of Tübingen, Tübingen, Germany
Støy J:
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
Taylor R:
University of Newcastle, Newcastle upon Tyne, UK
Tye SC:
Sections on Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, the Netherlands
Ukke GG:
Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia
Urazbayeva M:
Division of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Houston, TX, USA
Gastroenterology, Baylor College of Medicine, Houston, TX, USA
Van der Schueren B:
Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinologyó, KU Leuven, Leuven, Belgium
Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium
Vatier C:
Sorbonne University, Inserm U938, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition, Paris, France
Department of Endocrinology, Diabetology and Reproductive Endocrinology, Assistance Publique-Hôpitaux de Paris, Saint-Antoine University Hospital, National Reference Center for Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS), Paris, France
Wentworth JM:
Royal Melbourne Hospital Department of Diabetes and Endocrinology, Parkville, Victoria, Australia
Walter and Eliza Hall Institute, Parkville, Victoria, Australia
University of Melbourne Department of Medicine, Parkville, Victoria, Australia
Hannah W:
Deakin University, Melbourne, Victoria, Australia
Department of Epidemiology, Madras Diabetes Research Foundation, Chennai, India
White SL:
Department of Women and Children's Health, King's College London, London, UK
Department of Diabetes and Endocrinology, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, UK
Yu G:
Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China
Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
Zhang Y:
Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China
Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
Zhou SJ:
Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia
School of Agriculture, Food and Wine, University of Adelaide, Adelaide, South Australia, Australia
Beltrand J:
Institut Cochin, Inserm U 10116, Paris, France
Pediatric Endocrinology and Diabetes, Hopital Necker Enfants Malades, APHP Centre, Université de Paris, Paris, France
Polak M:
Institut Cochin, Inserm U 10116, Paris, France
Pediatric Endocrinology and Diabetes, Hopital Necker Enfants Malades, APHP Centre, Université de Paris, Paris, France
Aukrust I:
Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway
de Franco E:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Flanagan SE:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Maloney KA:
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
McGovern A:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Molnes J:
Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway
Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway
Nakabuye M:
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Njølstad PR:
Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway
Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway
Pomares-Millan H:
Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA
Provenzano M:
Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna, Bologna, Italy
Saint-Martin C:
Department of Medical Genetics, AP-HP Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France
Zhang C:
Global Center for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
Zhu Y:
Kaiser Permanente Northern California Division of Research, Oakland, CA, USA
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
Auh S:
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
de Souza R:
Population Health Research Institute, Hamilton, Ontario, Canada
Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Fawcett AJ:
Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Department of Clinical and Organizational Development, Chicago, IL, USA
Gruber C:
American Diabetes Association, Arlington, VA, USA
Mekonnen EG:
College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia
Global Health Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium
Mixter E:
Department of Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA
Sherifali D:
Population Health Research Institute, Hamilton, Ontario, Canada
School of Nursing, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
Eckel RH:
Division of Endocrinology, Metabolism, Diabetes, University of Colorado, Aurora, CO, USA
Nolan JJ:
Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland
Department of Endocrinology, Wexford General Hospital, Wexford, Ireland
Philipson LH:
Department of Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA
Brown RJ:
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Billings LK:
Division of Endocrinology, NorthShore University HealthSystem, Skokie, IL, USA
Department of Medicine, Prtizker School of Medicine, University of Chicago, Chicago, IL, USA
Boyle K:
Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Costacou T:
Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
Dennis JM:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Florez JC:
Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
Department of Medicine, Harvard Medical School, Boston, MA, USA
Gloyn AL:
Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA
Stanford Diabetes Research Center, Stanford School of Medicine, Stanford University, Stanford, CA, USA
Department of Genetics, Stanford School of Medicine, Stanford University, Stanford, CA, USA
Gomez MF:
Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Faculty of Health, Aarhus University, Aarhus, Denmark
Gottlieb PA:
Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Greeley SAW:
Departments of Pediatrics and Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA
Griffin K:
Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA
Sanford Research, Sioux Falls, SD, USA
Hattersley AT:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK
Hirsch IB:
University of Washington School of Medicine, Seattle, WA, USA
Hivert MF:
Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA
Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA
Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
Hood KK:
Stanford University School of Medicine, Stanford, CA, USA
Josefson JL:
Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Kwak SH:
Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea
Laffel LM:
Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
Lim SS:
Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia
Loos RJF:
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Ma RCW:
Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China
Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China
Mathieu C:
University Hospital Leuven, Leuven, Belgium
Mathioudakis N:
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Meigs JB:
Department of Medicine, Harvard Medical School, Boston, MA, USA
Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA
Broad Institute, Cambridge, MA, USA
Misra S:
Division of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
Department of Diabetes & Endocrinology, Imperial College Healthcare NHS Trust, London, UK
Mohan V:
Department of Diabetology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Chennai, India
Murphy R:
Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
Auckland Diabetes Centre, Te Whatu Ora Health New Zealand, Auckland, New Zealand
Medical Bariatric Service, Te Whatu Ora Counties, Health New Zealand, Auckland, New Zealand
Oram R:
Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK
Owen KR:
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK
Ozanne SE:
University of Cambridge, Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Cambridge, UK
Pearson ER:
Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK
Perng W:
Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Pollin TI:
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USA
Pop-Busui R:
Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA
Pratley RE:
AdventHealth Translational Research Institute, Orlando, FL, USA
Redman LM:
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Redondo MJ:
Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
Division of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Houston, TX, USA
Reynolds RM:
Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK
Semple RK:
Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK
MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
Sherr JL:
Yale School of Medicine, New Haven, CT, USA
Sims EK:
Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA
Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA
Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA
Sweeting A:
Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia
Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
Tuomi T:
Helsinki University Hospital, Abdominal Centre/Endocrinology, Helsinki, Finland
Folkhälsan Research Center, Helsinki, Finland
Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland
Udler MS:
Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA
Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
Department of Medicine, Harvard Medical School, Boston, MA, USA
Vesco KK:
Kaiser Permanente Northwest, Kaiser Permanente Center for Health Research, Portland, OR, USA
Vilsbøll T:
Clinial Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Wagner R:
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany
German Center for Diabetes Research (DZD), Neuherberg, Germany
Department of Endocrinology and Diabetology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany
Rich SS:
Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA
Franks PW:
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Department of Translational Medicine, Medical Science, Novo Nordisk Foundation, Hellerup, Denmark.
Bronze, All Open Access; Bronze
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