Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.


Por: Tobias DK, Merino J, Ahmad A, Aiken C, Benham JL, Bodhini D, Clark AL, Colclough K, Corcoy R, Cromer SJ, Duan D, Felton JL, Francis EC, Gillard P, Gingras V, Gaillard R, Haider E, Hughes A, Ikle JM, Jacobsen LM, Kahkoska AR, Kettunen JLT, Kreienkamp RJ, Lim LL, Männistö JME, Massey R, Mclennan NM, Miller RG, Morieri ML, Most J, Naylor RN, Ozkan B, Patel KA, Pilla SJ, Prystupa K, Raghavan S, Rooney MR, Schön M, Semnani-Azad Z, Sevilla-Gonzalez M, Svalastoga P, Takele WW, Tam CH, Thuesen ACB, Tosur M, Wallace AS, Wang CC, Wong JJ, Yamamoto JM, Young K, Amouyal C, Andersen MK, Bonham MP, Chen M, Cheng F, Chikowore T, Chivers SC, Clemmensen C, Dabelea D, Dawed AY, Deutsch AJ, Dickens LT, DiMeglio LA, Dudenhöffer-Pfeifer M, Evans-Molina C, Fernández-Balsells MM, Fitipaldi H, Fitzpatrick SL, Gitelman SE, Goodarzi MO, Grieger JA, Guasch-Ferré M, Habibi N, Hansen T, Huang C, Harris-Kawano A, Ismail HM, Hoag B, Johnson RK, Jones AG, Koivula RW, Leong A, Leung GKW, Libman IM, Liu K, Long SA, Lowe WL Jr, Morton RW, Motala AA, Onengut-Gumuscu S, Pankow JS, Pathirana M, Pazmino S, Perez D, Petrie JR, Powe CE, Quinteros A, Jain R, Ray D, Ried-Larsen M, Saeed Z, Santhakumar V, Kanbour S, Sarkar S, Monaco GSF, Scholtens DM, Selvin E, Sheu WH, Speake C, Stanislawski MA, Steenackers N, Steck AK, Stefan N, Støy J, Taylor R, Tye SC, Ukke GG, Urazbayeva M, Van der Schueren B, Vatier C, Wentworth JM, Hannah W, White SL, Yu G, Zhang Y, Zhou SJ, Beltrand J, Polak M, Aukrust I, de Franco E, Flanagan SE, Maloney KA, McGovern A, Molnes J, Nakabuye M, Njølstad PR, Pomares-Millan H, Provenzano M, Saint-Martin C, Zhang C, Zhu Y, Auh S, de Souza R, Fawcett AJ, Gruber C, Mekonnen EG, Mixter E, Sherifali D, Eckel RH, Nolan JJ, Philipson LH, Brown RJ, Billings LK, Boyle K, Costacou T, Dennis JM, Florez JC, Gloyn AL, Gomez MF, Gottlieb PA, Greeley SAW, Griffin K, Hattersley AT, Hirsch IB, Hivert MF, Hood KK, Josefson JL, Kwak SH, Laffel LM, Lim SS, Loos RJF, Ma RCW, Mathieu C, Mathioudakis N, Meigs JB, Misra S, Mohan V, Murphy R, Oram R, Owen KR, Ozanne SE, Pearson ER, Perng W, Pollin TI, Pop-Busui R, Pratley RE, Redman LM, Redondo MJ, Reynolds RM, Semple RK, Sherr JL, Sims EK, Sweeting A, Tuomi T, Udler MS, Vesco KK, Vilsbøll T, Wagner R, Rich SS, Franks PW

Publicada: 5 oct 2023 Ahead of Print: 5 oct 2023
Resumen:
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.

Filiaciones:
Tobias DK:
 Division of Preventative Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

 Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

Merino J:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

 Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA

 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA

Ahmad A:
 Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden

Aiken C:
 Department of Obstetrics and Gynaecology, The Rosie Hospital, Cambridge, UK

 NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK

Benham JL:
 Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Bodhini D:
 Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India

Clark AL:
 Division of Pediatric Endocrinology, Department of Pediatrics, Saint Louis University School of Medicine, SSM Health Cardinal Glennon Children's Hospital, St. Louis, MO, USA

Colclough K:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

Corcoy R:
 CIBER-BBN, ISCIII, Madrid, Spain

 Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Barcelona, Spain

 Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain

Cromer SJ:
 Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA

 Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA

 Department of Medicine, Harvard Medical School, Boston, MA, USA

Duan D:
 Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA

Felton JL:
 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA

 Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA

 Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA

Francis EC:
 Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA

Gillard P:
 University Hospital Leuven, Leuven, Belgium

Gingras V:
 Department of Nutrition, Université de Montréal, Montreal, Quebec, Quebec, Canada

 Research Center, Sainte-Justine University Hospital Center, Montreal, Quebec, Quebec, Canada

Gaillard R:
 Department of Pediatrics, Erasmus Medical Center, Rotterdam, the Netherlands

Haider E:
 Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK

Hughes A:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

Ikle JM:
 Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA

 Stanford Diabetes Research Center, Stanford School of Medicine, Stanford University, Stanford, CA, USA

Jacobsen LM:
 University of Florida, Gainesville, FL, USA

Kahkoska AR:
 Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Kettunen JLT:
 Helsinki University Hospital, Abdominal Centre/Endocrinology, Helsinki, Finland

 Folkhälsan Research Center, Helsinki, Finland

 Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland

Kreienkamp RJ:
 Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA

 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA

 Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA

 Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital, Boston, MA, USA

Lim LL:
 Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

 Asia Diabetes Foundation, Hong Kong SAR, China

 Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China

Männistö JME:
 Departments of Pediatrics and Clinical Genetics, Kuopio University Hospital, Kuopio, Finland

 Department of Medicine, University of Eastern Finland, Kuopio, Finland

Massey R:
 Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK

Mclennan NM:
 Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK

Miller RG:
 Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA

Morieri ML:
 Metabolic Disease Unit, University Hospital of Padova, Padova, Italy

 Department of Medicine, University of Padova, Padova, Italy

Most J:
 Department of Orthopedics, Zuyderland Medical Center, Sittard-Geleen, The Netherlands

Naylor RN:
 Departments of Pediatrics and Medicine, University of Chicago, Chicago, IL, USA

Ozkan B:
 Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

 Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine, Baltimore, MD, USA

Patel KA:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

Pilla SJ:
 Department of Medicine, Johns Hopkins University, Baltimore, MD, USA

 Department of Health Policy and Management, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA

Prystupa K:
 Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany

 German Center for Diabetes Research (DZD), Neuherberg, Germany

Raghavan S:
 Section of Academic Primary Care, US Department of Veterans Affairs Eastern Colorado Health Care System, Aurora, CO, USA

 Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA

Rooney MR:
 Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Schön M:
 Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany

 German Center for Diabetes Research (DZD), Neuherberg, Germany

 Institute of Diabetes Research and Metabolic Diseases (IDM), Helmholtz Center Munich, Neuherberg, Germany

 Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia

Semnani-Azad Z:
 Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

Sevilla-Gonzalez M:
 Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA

 Department of Medicine, Harvard Medical School, Boston, MA, USA

 Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA

Svalastoga P:
 Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway

 Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway

Takele WW:
 Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia

Tam CH:
 Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China

 Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

 Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China

Thuesen ACB:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Tosur M:
 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

 Division of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Houston, TX, USA

 Children's Nutrition Research Center, USDA/ARS, Houston, TX, USA

Wallace AS:
 Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Wang CC:
 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Wong JJ:
 Stanford University School of Medicine, Stanford, CA, USA

Yamamoto JM:
 Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada

Young K:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

Amouyal C:
 Department of Diabetology, APHP, Paris, France

 Sorbonne Université, INSERM, NutriOmic team, Paris, France

Andersen MK:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Bonham MP:
 Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia

Chen M:
 Monash Centre for Health Research and Implementation, Monash University, Clayton, Victoria, Australia

Cheng F:
 Health Management Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China

Chikowore T:
 Department of Medicine, Harvard Medical School, Boston, MA, USA

 MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

 Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA

 Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Chivers SC:
 Department of Women and Children's Health, King's College London, London, UK

Clemmensen C:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Dabelea D:
 Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Dawed AY:
 Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK

Deutsch AJ:
 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA

 Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA

 Department of Medicine, Harvard Medical School, Boston, MA, USA

Dickens LT:
 Section of Adult and Pediatric Endocrinology, Diabetes and Metabolism, Kovler Diabetes Center, University of Chicago, Chicago, IL, USA

DiMeglio LA:
 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA

 Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA

 Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA

 Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA

Dudenhöffer-Pfeifer M:
 Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden

Evans-Molina C:
 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA

 Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA

 Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA

 Richard L. Roudebush VAMC, Indianapolis, IN, USA

Fernández-Balsells MM:
 Biomedical Research Institute Girona, IdIBGi, Girona, Spain

 Diabetes, Endocrinology and Nutrition Unit Girona, University Hospital Dr Josep Trueta, Girona, Spain

Fitipaldi H:
 Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden

Fitzpatrick SL:
 Institute of Health System Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA

Gitelman SE:
 University of California at San Francisco, Department of Pediatrics, Diabetes Center, San Francisco, CA, USA

Goodarzi MO:
 Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA

 Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Grieger JA:
 Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia

 Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia

Guasch-Ferré M:
 Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

 Department of Public Health and Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Habibi N:
 Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia

 Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia

Hansen T:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Huang C:
 Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China

 Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

Harris-Kawano A:
 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA

 Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA

 Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA

Ismail HM:
 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA

 Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA

 Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA

Hoag B:
 Division of Endocrinology and Diabetes, Department of Pediatrics, Sanford Children's Hospital, Sioux Falls, SD, USA

 University of South Dakota School of Medicine, E Clark St, Vermillion, SD, USA

Johnson RK:
 Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

 Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA

Jones AG:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

 Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK

Koivula RW:
 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

Leong A:
 Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA

 Department of Medicine, Harvard Medical School, Boston, MA, USA

 Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA

Leung GKW:
 Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Victoria, Australia

Libman IM:
 UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA

Liu K:
 Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia

Long SA:
 Center for Translational Immunology, Benaroya Research Institute, Seattle, WA, USA

Lowe WL Jr:
 Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Morton RW:
 Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

 Population Health Research Institute, Hamilton, Ontario, Canada

 Department of Translational Medicine, Medical Science, Novo Nordisk Foundation, Hellerup, Denmark

Motala AA:
 Department of Diabetes and Endocrinology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

Onengut-Gumuscu S:
 Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA

Pankow JS:
 Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA

Pathirana M:
 Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia

 Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia

Pazmino S:
 Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinologyó, KU Leuven, Leuven, Belgium

Perez D:
 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA

 Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA

 Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA

Petrie JR:
 School of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

Powe CE:
 Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA

 Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA

 Department of Medicine, Harvard Medical School, Boston, MA, USA

 Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

Quinteros A:
 Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia

Jain R:
 Sanford Children's Specialty Clinic, Sioux Falls, SD, USA

 Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA

Ray D:
 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Ried-Larsen M:
 Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark

 Institute for Sports and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark

Saeed Z:
 Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Indiana University School of Medicine, Indianapolis, IN, USA

Santhakumar V:
 Division of Preventative Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

Kanbour S:
 Department of Medicine, Johns Hopkins University, Baltimore, MD, USA

 AMAN Hospital, Doha, Qatar

Sarkar S:
 Department of Medicine, Johns Hopkins University, Baltimore, MD, USA

Monaco GSF:
 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA

 Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA

 Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA

Scholtens DM:
 Department of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Selvin E:
 Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Sheu WH:
 Institute of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan

 Divsion of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan

 Division of Endocrinology and Metabolism, Taipei Veterans General Hospital, Taipei, Taiwan

Speake C:
 Center for Interventional Immunology, Benaroya Research Institute, Seattle, WA, USA

Stanislawski MA:
 Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Steenackers N:
 Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinologyó, KU Leuven, Leuven, Belgium

Steck AK:
 Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Stefan N:
 German Center for Diabetes Research (DZD), Neuherberg, Germany

 Institute of Diabetes Research and Metabolic Diseases (IDM), Helmholtz Center Munich, Neuherberg, Germany

 University Hospital of Tübingen, Tübingen, Germany

Støy J:
 Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

Taylor R:
 University of Newcastle, Newcastle upon Tyne, UK

Tye SC:
 Sections on Genetics and Epidemiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA

 Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, the Netherlands

Ukke GG:
 Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia

Urazbayeva M:
 Division of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Houston, TX, USA

 Gastroenterology, Baylor College of Medicine, Houston, TX, USA

Van der Schueren B:
 Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinologyó, KU Leuven, Leuven, Belgium

 Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium

Vatier C:
 Sorbonne University, Inserm U938, Saint-Antoine Research Centre, Institute of Cardiometabolism and Nutrition, Paris, France

 Department of Endocrinology, Diabetology and Reproductive Endocrinology, Assistance Publique-Hôpitaux de Paris, Saint-Antoine University Hospital, National Reference Center for Rare Diseases of Insulin Secretion and Insulin Sensitivity (PRISIS), Paris, France

Wentworth JM:
 Royal Melbourne Hospital Department of Diabetes and Endocrinology, Parkville, Victoria, Australia

 Walter and Eliza Hall Institute, Parkville, Victoria, Australia

 University of Melbourne Department of Medicine, Parkville, Victoria, Australia

Hannah W:
 Deakin University, Melbourne, Victoria, Australia

 Department of Epidemiology, Madras Diabetes Research Foundation, Chennai, India

White SL:
 Department of Women and Children's Health, King's College London, London, UK

 Department of Diabetes and Endocrinology, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, UK

Yu G:
 Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China

 Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

Zhang Y:
 Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China

 Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

Zhou SJ:
 Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia

 School of Agriculture, Food and Wine, University of Adelaide, Adelaide, South Australia, Australia

Beltrand J:
 Institut Cochin, Inserm U 10116, Paris, France

 Pediatric Endocrinology and Diabetes, Hopital Necker Enfants Malades, APHP Centre, Université de Paris, Paris, France

Polak M:
 Institut Cochin, Inserm U 10116, Paris, France

 Pediatric Endocrinology and Diabetes, Hopital Necker Enfants Malades, APHP Centre, Université de Paris, Paris, France

Aukrust I:
 Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway

 Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway

de Franco E:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

Flanagan SE:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

Maloney KA:
 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA

McGovern A:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

Molnes J:
 Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway

 Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway

Nakabuye M:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Njølstad PR:
 Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway

 Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway

Pomares-Millan H:
 Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden

 Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA

Provenzano M:
 Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum University of Bologna, Bologna, Italy

Saint-Martin C:
 Department of Medical Genetics, AP-HP Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France

Zhang C:
 Global Center for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

 Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Zhu Y:
 Kaiser Permanente Northern California Division of Research, Oakland, CA, USA

 Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA

Auh S:
 National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

de Souza R:
 Population Health Research Institute, Hamilton, Ontario, Canada

 Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

Fawcett AJ:
 Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

 Department of Clinical and Organizational Development, Chicago, IL, USA

Gruber C:
 American Diabetes Association, Arlington, VA, USA

Mekonnen EG:
 College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia

 Global Health Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium

Mixter E:
 Department of Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA

Sherifali D:
 Population Health Research Institute, Hamilton, Ontario, Canada

 School of Nursing, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada

Eckel RH:
 Division of Endocrinology, Metabolism, Diabetes, University of Colorado, Aurora, CO, USA

Nolan JJ:
 Department of Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland

 Department of Endocrinology, Wexford General Hospital, Wexford, Ireland

Philipson LH:
 Department of Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA

Brown RJ:
 National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

Billings LK:
 Division of Endocrinology, NorthShore University HealthSystem, Skokie, IL, USA

 Department of Medicine, Prtizker School of Medicine, University of Chicago, Chicago, IL, USA

Boyle K:
 Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Costacou T:
 Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA

Dennis JM:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

Florez JC:
 Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA

 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA

 Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA

 Department of Medicine, Harvard Medical School, Boston, MA, USA

Gloyn AL:
 Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA

 Stanford Diabetes Research Center, Stanford School of Medicine, Stanford University, Stanford, CA, USA

 Department of Genetics, Stanford School of Medicine, Stanford University, Stanford, CA, USA

Gomez MF:
 Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden

 Faculty of Health, Aarhus University, Aarhus, Denmark

Gottlieb PA:
 Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Greeley SAW:
 Departments of Pediatrics and Medicine and Kovler Diabetes Center, University of Chicago, Chicago, IL, USA

Griffin K:
 Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA

 Sanford Research, Sioux Falls, SD, USA

Hattersley AT:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

 Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK

Hirsch IB:
 University of Washington School of Medicine, Seattle, WA, USA

Hivert MF:
 Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA

 Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA

 Department of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada

Hood KK:
 Stanford University School of Medicine, Stanford, CA, USA

Josefson JL:
 Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Kwak SH:
 Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea

Laffel LM:
 Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA

Lim SS:
 Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia

Loos RJF:
 Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

 Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Ma RCW:
 Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China

 Laboratory for Molecular Epidemiology in Diabetes, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

 Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China

Mathieu C:
 University Hospital Leuven, Leuven, Belgium

Mathioudakis N:
 Department of Medicine, Johns Hopkins University, Baltimore, MD, USA

Meigs JB:
 Department of Medicine, Harvard Medical School, Boston, MA, USA

 Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA

 Broad Institute, Cambridge, MA, USA

Misra S:
 Division of Metabolism, Digestion and Reproduction, Imperial College London, London, UK

 Department of Diabetes & Endocrinology, Imperial College Healthcare NHS Trust, London, UK

Mohan V:
 Department of Diabetology, Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Chennai, India

Murphy R:
 Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand

 Auckland Diabetes Centre, Te Whatu Ora Health New Zealand, Auckland, New Zealand

 Medical Bariatric Service, Te Whatu Ora Counties, Health New Zealand, Auckland, New Zealand

Oram R:
 Department of Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK

 Royal Devon University Healthcare NHS Foundation Trust, Exeter, UK

Owen KR:
 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK

 Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK

Ozanne SE:
 University of Cambridge, Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, Cambridge, UK

Pearson ER:
 Division of Population Health & Genomics, School of Medicine, University of Dundee, Dundee, UK

Perng W:
 Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

Pollin TI:
 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA

 Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USA

Pop-Busui R:
 Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, USA

Pratley RE:
 AdventHealth Translational Research Institute, Orlando, FL, USA

Redman LM:
 Pennington Biomedical Research Center, Baton Rouge, LA, USA

Redondo MJ:
 Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

 Division of Pediatric Diabetes and Endocrinology, Texas Children's Hospital, Houston, TX, USA

Reynolds RM:
 Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK

Semple RK:
 Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK

 MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK

Sherr JL:
 Yale School of Medicine, New Haven, CT, USA

Sims EK:
 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA

 Herman B Wells Center for Pediatric Research, University School of Medicine, Indianapolis, IN, USA

 Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA

Sweeting A:
 Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia

 Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia

Tuomi T:
 Helsinki University Hospital, Abdominal Centre/Endocrinology, Helsinki, Finland

 Folkhälsan Research Center, Helsinki, Finland

 Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland

Udler MS:
 Diabetes Unit, Endocrine Division, Massachusetts General Hospital, Boston, MA, USA

 Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA

 Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA

 Department of Medicine, Harvard Medical School, Boston, MA, USA

Vesco KK:
 Kaiser Permanente Northwest, Kaiser Permanente Center for Health Research, Portland, OR, USA

Vilsbøll T:
 Clinial Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

 Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Wagner R:
 Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany

 German Center for Diabetes Research (DZD), Neuherberg, Germany

 Department of Endocrinology and Diabetology, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

Rich SS:
 Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA

Franks PW:
 Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

 Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden.

 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.

 Department of Translational Medicine, Medical Science, Novo Nordisk Foundation, Hellerup, Denmark.
ISSN: 10788956
Editorial
NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 29 Número: 10
Páginas: 2438-2457
WOS Id: 001085074500001
ID de PubMed: 37794253
imagen Bronze, All Open Access; Bronze

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