The Free and Cued Selective Reminding Test in Parkinson's Disease Mild Cognitive Impairment: Discriminative Accuracy and Neural Correlates
Por:
Horta-Barba, A, Pagonabarraga, J, Martinez-Horta, S, Marin-Lahoz, J, Sampedro, F, Fernandez-Bobadilla, R, Boti, MA, Bejr-Kasem, H, Aracil-Bolanos, I, Perez-Perez, J, Pascual-Sedano, B, Campolongo, A, Izquierdo, C, Gomez-Anson, B, Kulisevsky, J
Publicada:
21 abr 2020
Resumen:
Introduction: Memory alterations are common in Parkinson's disease (PD) patients but the mechanisms involved in these deficits remain poorly understood. The study aims to explore the profile of episodic memory deficits in non-demented early PD patients.
Methods: We obtained neurological, cognitive and behavioral data from 114 PD patients and 41 healthy controls (HC). PD participants were grouped as normal cognition (PD-NC) and mild cognitive impairment (PD-MCI) according to the Level II criteria of the Movement Disorders Society Task Force (MDS-TF). We evaluate the performance amongst groups on an episodic memory task using the Free and Cued Selective Reminding Test (FCSRT). Additionally, gray matter volume (GMV) voxel based morphometry, and mean diffusivity (MD) analyses were conducted in a subset of patients to explore the structural brain correlates of FCSRT performance.
Results: Performance on all subscores of the FCSRT was significantly worse in PD-MCI than in PD-NC and HC. Delayed total recall (DTR) subscore was the best at differentiating PD-NC from PD-MCI. Using crosstabulation, DTR allowed identification of PD-MCI patients with an accuracy of 80%. Delayed free and cued recall was associated with decreased GMV and increased MD in multiple fronto-temporal and parietal areas.
Conclusion: Encoding and retrieval deficits are a main characteristic of PD-MCI and are associated with structural damage in temporal, parietal and prefrontal areas.
Filiaciones:
Horta-Barba, A:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Autonomous Univ Barcelona, Barcelona, Spain
Pagonabarraga, J:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Autonomous Univ Barcelona, Barcelona, Spain
Martinez-Horta, S:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Autonomous Univ Barcelona, Barcelona, Spain
Marin-Lahoz, J:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Autonomous Univ Barcelona, Barcelona, Spain
Sampedro, F:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Fernandez-Bobadilla, R:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Boti, MA:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Bejr-Kasem, H:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Aracil-Bolanos, I:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Perez-Perez, J:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Pascual-Sedano, B:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Autonomous Univ Barcelona, Barcelona, Spain
Campolongo, A:
Biomed Res Inst IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Izquierdo, C:
Biomed Res Inst IIB St Pau, Barcelona, Spain
Gomez-Anson, B:
Biomed Res Inst IIB St Pau, Barcelona, Spain
Autonomous Univ Barcelona, Barcelona, Spain
St Pau Hosp, Neuroradiol Unit, Barcelona, Spain
Kulisevsky, J:
St Pau Hosp, Neurol Dept, Movement Disorders Unit, Barcelona, Spain
Biomed Res Inst IIB St Pau, Barcelona, Spain
Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Barcelona, Spain
Autonomous Univ Barcelona, Barcelona, Spain
Gold, Green Published
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