No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis
Por:
de Kovel, CGF, Aftanas, L, Aleman, A, Alexander-Bloch, AF, Baune, BT, Brack, I, Bulow, R, Busatto, G, Carballedo, A, Connolly, CG, Cullen, KR, Dannlowski, U, Davey, CG, Dima, D, Dohm, K, Erwin-Grabner, T, Frodl, T, Fu, CHY, Hall, GB, Glahn, DC, Godlewska, B, Gotlib, IH, Goya-Maldonado, R, Grabe, HJ, Groenewold, NA, Grotegerd, D, Gruber, O, Harris, MA, Harrison, BJ, Hatton, SN, Hickie, IB, Ho, TC, Jahanshad, N, Kircher, T, Kramer, B, Krug, A, Lagopoulos, J, Leehr, EJ, Li, M, MacMaster, FP, MacQueen, G, McIntosh, AM, McLellan, Q, Medland, SE, Mueller, BA, Nenadic, I, Osipov, E, Papmeyer, M, Portella, MJ, Reneman, L, Rosa, PGP, Sacchet, MD, Schnell, K, Schrantee, A, Sim, K, Simulionyte, E, Sindermann, L, Van der Werff, SJA, Veer, IM, Vives-Gilabert, Y, Volzke, H, Walter, H, Walter, M, Schreiner, MW, Whalley, H, Winter, N, Wittfeld, K, Yang, TT, Yuksel, D, Zaremba, D, Thompson, PM, Veltman, DJ, Schmaal, L, Francks, C
Publicada:
1 dic 2019
Resumen:
Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects.
Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T-1-weighted MRI data were processedwith a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1.
Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset.
Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.
Filiaciones:
de Kovel, CGF:
Max Planck Inst Psycholinguist, Dept Language & Genet, Nijmegen, Netherlands
Aftanas, L:
Sci Res Inst Physiol & Basic Med, Lab Affect Cognit & Translat Neurosci, Novosibirsk, Russia
Novosibirsk State Univ, Dept Neurosci, Novosibirsk, Russia
Aleman, A:
Univ Groningen, Univ Med Ctr Groningen, Neuroimaging Ctr, Dept Neurosci, Groningen, Netherlands
Univ Groningen, Dept Psychol, Groningen, Netherlands
Alexander-Bloch, AF:
Yale Sch Med, Dept Psychiat, New Haven, CT USA
Baune, BT:
Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia
Brack, I:
Sci Res Inst Physiol & Basic Med, Lab Affect Cognit & Translat Neurosci, Novosibirsk, Russia
Bulow, R:
Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol, Greifswald, Germany
Busatto, G:
Univ Sao Paulo, Dept & Inst Psiquiatria, Hosp Clin HCFMUSP, Fac Med,Lab Psychiatr Neuroimaging LIM 21, Sao Paulo, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci, Sao Paulo, SP, Brazil
Carballedo, A:
Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland
Connolly, CG:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
Univ Calif San Francisco, Div Child & Adolescent Psychiat, Weill Inst Neurosci, San Francisco, CA 94143 USA
Florida State Univ, Dept Biomed Sci, Tallahassee, FL 32306 USA
Cullen, KR:
Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Dannlowski, U:
Univ Munster, Dept Psychiat, Munster, Germany
Davey, CG:
Orygen, Natl Ctr Excellence Youth Mental Hlth, Melbourne, Vic, Australia
Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia
Dima, D:
City Univ London, Sch Arts & Social Sci, Dept Psychol, London, England
Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London, England
Dohm, K:
Univ Munster, Dept Psychiat, Munster, Germany
Erwin-Grabner, T:
Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
Frodl, T:
Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland
Otto von Guericke Univ, Dept Psychiat & Psychotherapy, Magdeburg, Germany
Fu, CHY:
Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Affect Disorders, London, England
Univ East London, Sch Psychol, London, England
Hall, GB:
McMaster Univ, Dept Psychol Neurosci & Behav, Hamilton, ON, Canada
Glahn, DC:
Yale Sch Med, Dept Psychiat, New Haven, CT USA
Godlewska, B:
Univ Oxford, Dept Psychiat, Psychopharmacol Res Unit, Oxford, England
Gotlib, IH:
Stanford Univ, Dept Psychol, Stanford, CA USA
Goya-Maldonado, R:
Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
Grabe, HJ:
Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany
German Ctr Neurodegenerat Dis, Site Rostock Greifswald, Rostock, Germany
Groenewold, NA:
Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Dept Psychiat, Groningen, Netherlands
Univ Cape Town, Dept Psychiat, Med Res Council Unit Risk & Resilience Mental Dis, Cape Town, South Africa
Grotegerd, D:
Univ Munster, Dept Psychiat, Munster, Germany
Gruber, O:
Heidelberg Univ, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging, Heidelberg, Germany
Harris, MA:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Harrison, BJ:
Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia
Melbourne Hlth, Melbourne, Vic, Australia
Hickie, IB:
Univ Sydney, Youth Mental Hlth Team, Brain & Mind Ctr, Sydney, NSW, Australia
Ho, TC:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
Univ Calif San Francisco, Div Child & Adolescent Psychiat, Weill Inst Neurosci, San Francisco, CA 94143 USA
Stanford Univ, Dept Psychol, Stanford, CA USA
Jahanshad, N:
Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA
Kircher, T:
Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
Kramer, B:
Heidelberg Univ, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging, Heidelberg, Germany
Krug, A:
Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
Lagopoulos, J:
Univ Sydney, Youth Mental Hlth Team, Brain & Mind Ctr, Sydney, NSW, Australia
Sunshine Coast Mind & Neurosci Thompson Inst, Birtinya, Qld, Australia
Leehr, EJ:
Univ Munster, Dept Psychiat, Munster, Germany
Li, M:
Univ Magdeburg, Dept Neurol, Magdeburg, Germany
MacMaster, FP:
Univ Calgary, Dept Psychiat, Calgary, AB, Canada
Univ Calgary, Dept Paediat, Calgary, AB, Canada
Strateg Clin Network Addict & Mental Hlth, Edmonton, AB, Canada
MacQueen, G:
Univ Calgary, Cumming Sch Med, Dept Psychiat, Calgary, AB, Canada
McIntosh, AM:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland
McLellan, Q:
Univ Calgary, Dept Psychiat, Calgary, AB, Canada
Univ Calgary, Dept Paediat, Calgary, AB, Canada
Medland, SE:
QIMR Berghofer Med Res Inst, Psychiat Genet, Brisbane, Qld, Australia
Mueller, BA:
Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Nenadic, I:
Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
Osipov, E:
Sci Res Inst Physiol & Basic Med, Lab Affect Cognit & Translat Neurosci, Novosibirsk, Russia
Papmeyer, M:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Swiss Parapleg Res, Rehabil Serv & Care Unit, Nottwil, Switzerland
Portella, MJ:
Inst Biomed Res St Pau, Dept Psychiat, Barcelona, Spain
CIBERSAM, Madrid, Spain
Reneman, L:
Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands
Rosa, PGP:
Univ Sao Paulo, Dept & Inst Psiquiatria, Hosp Clin HCFMUSP, Fac Med,Lab Psychiatr Neuroimaging LIM 21, Sao Paulo, Brazil
Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci, Sao Paulo, SP, Brazil
Sacchet, MD:
Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
Schnell, K:
Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany
Schrantee, A:
Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands
Royal Netherlands Acad Arts & Sci, Spinoza Ctr Neuroimaging, Amsterdam, Netherlands
Sim, K:
Inst Mental Hlth, West Reg & Res Div, Singapore, Singapore
Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore
Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Simulionyte, E:
Heidelberg Univ, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging, Heidelberg, Germany
Sindermann, L:
Univ Munster, Dept Psychiat, Munster, Germany
Van der Werff, SJA:
Leids Univ, Med Centrum, Brain Funct & Dysfunct, Leiden, Netherlands
Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands
Leiden Inst Brain & Cognit, Leiden, Netherlands
Veer, IM:
Charite Univ Med Berlin, Dept Psychiat & Psychotherapy CCM, Div Mind & Brain Res, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Berlin Inst Hlth, Berlin, Germany
Vives-Gilabert, Y:
Univ Politecn Valencia, Inst ITACA, Inst Informat & Commun Technol, Valencia, Spain
Volzke, H:
Univ Med Greifswald, Inst Community Med, Greifswald, Germany
German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany
Walter, H:
Charite Univ Med Berlin, Dept Psychiat & Psychotherapy CCM, Div Mind & Brain Res, Berlin, Germany
Free Univ Berlin, Berlin, Germany
Humboldt Univ, Berlin, Germany
Berlin Inst Hlth, Berlin, Germany
Walter, M:
Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany
Schreiner, MW:
Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA
Univ Minnesota, Dept Psychol, Minneapolis, MN USA
Whalley, H:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Winter, N:
Univ Munster, Dept Psychiat, Munster, Germany
Wittfeld, K:
Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany
German Ctr Neurodegenerat Dis, Site Rostock Greifswald, Rostock, Germany
Yang, TT:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
Univ Calif San Francisco, Div Child & Adolescent Psychiat, Weill Inst Neurosci, San Francisco, CA 94143 USA
Yuksel, D:
Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
Zaremba, D:
Univ Munster, Dept Psychiat, Munster, Germany
Thompson, PM:
Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Mark & Mary Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA USA
Veltman, DJ:
Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Neurosci Campus Amsterdam, Amsterdam, Netherlands
Schmaal, L:
Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia
Francks, C:
Max Planck Inst Psycholinguist, Dept Language & Genet, Nijmegen, Netherlands
Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands
Boston Univ, Sch Publ Hlth, Boston, MA USA.
Green Submitted, Bronze, Green Accepted
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