Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group
Por:
Leerssen, J, Blanken, TF, Pozzi, E, Jahanshad, N, Aftanas, L, Andreassen, OA, Baune, BT, Brack, I, Carballedo, A, Ching, CRK, Dannlowski, U, Dohm, K, Enneking, V, Filimonova, E, Fingas, SM, Frodl, T, Godlewska, BR, Goltermann, J, Gotlib, IH, Grotegerd, D, Gruber, O, Harris, MA, Hatton, SN, Hawkins, E, Hickie, IB, Jaworska, N, Kircher, T, Krug, A, Lagopoulos, J, Lemke, H, Li, M, MacMaster, FP, McIntosh, AM, McLellan, Q, Meinert, S, Mwangi, B, Nenadic, I, Osipov, E, Portella, MJ, Redlich, R, Repple, J, Sacchet, MD, Samann, PG, Simulionyte, E, Soares, JC, Walter, M, Watanabe, N, Whalley, HC, Yuksel, D, Veltman, DJ, Thompson, PM, Schmaal, L, Van Someren, EJW
Publicada:
8 dic 2020
Resumen:
It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of overall depression severity. Disease specificity was evaluated in two independent samples comprising 2108 healthy controls, and in 260 clinical controls with bipolar disorder. Results showed that MDD patients with more severe insomnia had a smaller cortical surface area, mostly driven by the right insula, left inferior frontal gyrus pars triangularis, left frontal pole, right superior parietal cortex, right medial orbitofrontal cortex, and right supramarginal gyrus. Associations were specific for insomnia severity, and were not found for overall depression severity. Associations were also specific to MDD; healthy controls and clinical controls showed differential insomnia severity association profiles. The findings indicate that MDD patients with more severe insomnia show smaller surfaces in several frontoparietal cortical areas. While explained variance remains small, symptom-specific associations could bring us closer to clues on underlying biological phenomena of MDD.
Filiaciones:
Leerssen, J:
Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Dept Sleep & Cognit, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam Neurosci, Ctr Neurogen & Cognit Res CNCR, Dept Integrat Neurophysiol, Amsterdam, Netherlands
Blanken, TF:
Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Dept Sleep & Cognit, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam Neurosci, Ctr Neurogen & Cognit Res CNCR, Dept Integrat Neurophysiol, Amsterdam, Netherlands
Pozzi, E:
Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia
Melbourne Hlth, Melbourne, Vic, Australia
Orygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic, Australia
Jahanshad, N:
Univ Southern Calif, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA USA
Aftanas, L:
Sci Res Inst Neurosci & Med, Dept Clin Neurosci Behav & Neurotechnol, Novosibirsk, Russia
Novosibirsk State Univ, Dept Neurosci, Novosibirsk, Russia
Andreassen, OA:
Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT Ctr, Oslo, Norway
Univ Oslo, Inst Clin Med, Oslo, Norway
Baune, BT:
Univ Melbourne, Melbourne Med Sch, Dept Psychiat, Parkville, Vic, Australia
Univ Munster, Dept Psychiat, Munster, Germany
Brack, I:
Sci Res Inst Neurosci & Med, Dept Clin Neurosci Behav & Neurotechnol, Novosibirsk, Russia
Carballedo, A:
Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland
Ching, CRK:
Univ Southern Calif, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA USA
Dannlowski, U:
Univ Munster, Dept Psychiat, Munster, Germany
Dohm, K:
Univ Munster, Dept Psychiat, Munster, Germany
Enneking, V:
Univ Munster, Dept Psychiat, Munster, Germany
Filimonova, E:
Sci Res Inst Neurosci & Med, Dept Clin Neurosci Behav & Neurotechnol, Novosibirsk, Russia
Fingas, SM:
Univ Munster, Dept Psychiat, Munster, Germany
Frodl, T:
Trinity Coll Dublin, Dept Psychiat, Dublin, Ireland
Otto von Guericke Univ, Dept Psychiat & Psychotherapy, Magdeburg, Germany
Godlewska, BR:
Univ Oxford, Dept Psychiat, Psychopharmacol Res Unit, Oxford, England
Goltermann, J:
Univ Munster, Dept Psychiat, Munster, Germany
Gotlib, IH:
Stanford Univ, Dept Psychol, Stanford, CA USA
Grotegerd, D:
Univ Munster, Dept Psychiat, Munster, Germany
Gruber, O:
Heidelberg Univ, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging, Heidelberg, Germany
Harris, MA:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Hatton, SN:
Univ Sydney, Youth Mental Hlth Team Brain & Mind Ctr, Sydney, NSW, Australia
Hawkins, E:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Hickie, IB:
Univ Sydney, Youth Mental Hlth Team Brain & Mind Ctr, Sydney, NSW, Australia
Jaworska, N:
Univ Ottawa, Inst Mental Hlth Res, Ottawa, ON, Canada
Univ Ottawa, Cellular Mol Med, Ottawa, ON, Canada
Kircher, T:
Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
Krug, A:
Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany
Lagopoulos, J:
Sunshine Coast Mind & Neurosci Thompson Inst, Birtinya, Qld, Australia
Lemke, H:
Univ Munster, Dept Psychiat, Munster, Germany
Li, M:
Jena Univ Hosp, Dept Psychiat & Psychotherapy, Jena, Germany
Max Planck Inst Biol Cybernet, Tubingen, Germany
MacMaster, FP:
Univ Calgary, Psychiat & Paediat, Calgary, AB, Canada
Strateg Clin Network Addict & Mental Hlth, Calgary, AB, Canada
McIntosh, AM:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland
McLellan, Q:
Univ Calgary, Psychiat & Paediat, Calgary, AB, Canada
Univ Alberta, Fac Med & Dent, Edmonton, AB, Canada
Meinert, S:
Univ Munster, Dept Psychiat, Munster, Germany
Mwangi, B:
Univ Texas Hlth Sci Ctr Houston, Dept Psychiat, Houston, TX 77030 USA
Nenadic, I:
Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
Osipov, E:
Sci Res Inst Neurosci & Med, Dept Clin Neurosci Behav & Neurotechnol, Novosibirsk, Russia
Portella, MJ:
Inst Biomed Res St Pau, Dept Psychiat, Barcelona, Spain
CIBERSAM, Barcelona, Spain
Redlich, R:
Univ Munster, Dept Psychiat, Munster, Germany
Univ Halle, Dept Psychol, Halle, Germany
Repple, J:
Univ Munster, Dept Psychiat, Munster, Germany
Sacchet, MD:
Harvard Med Sch, McLean Hosp, Ctr Depress Anxiety & Stress Res, Belmont, MA USA
Samann, PG:
Max Planck Inst Psychiat, Munich, Germany
Simulionyte, E:
Heidelberg Univ, Dept Gen Psychiat, Sect Expt Psychopathol & Neuroimaging, Heidelberg, Germany
Soares, JC:
Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, UT Ctr Excellence Mood Disorders, Houston, TX 77030 USA
Walter, M:
Jena Univ Hosp, Dept Psychiat & Psychotherapy, Jena, Germany
Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany
Watanabe, N:
Kyoto Univ, Sch Publ Hlth, Dept Hlth Promot & Human Behav, Grad Sch Publ Hlth, Kyoto, Japan
Whalley, HC:
Univ Edinburgh, Div Psychiat, Edinburgh, Midlothian, Scotland
Yuksel, D:
Philipps Univ Marburg, Dept Psychiat & Psychotherapy, Marburg, Germany
SRI Int, Ctr Hlth Sci, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA
Veltman, DJ:
Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam Neurosci, Med Ctr, Amsterdam, Netherlands
Thompson, PM:
Univ Southern Calif, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Marina Del Rey, CA USA
Schmaal, L:
Orygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic, Australia
Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia
Van Someren, EJW:
Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Dept Sleep & Cognit, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam Neurosci, Ctr Neurogen & Cognit Res CNCR, Dept Integrat Neurophysiol, Amsterdam, Netherlands
Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands
Green Published, gold
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