Evaluation of canine leishmaniosis vaccine CaniLeish (R) under field conditions in native dog populations from an endemic Mediterranean area-A randomized controlled trial


Por: Velez, R, Domenech, E, Rodriguez-Cortes, A, Barrios, D, Tebar, S, Fernandez-Arevalo, A, Aguilar, R, Dobano, C, Alberola, J, Cairo, J, Gallego, M

Publicada: 1 may 2020
Resumen:
Dog vaccination is considered an effective way of reducing Leishmania infantum infection incidence in the canine population, as well as its transmission to humans. However, the use of partially effective vaccines can have the detrimental effect of "masking" vaccinated asymptomatic carriers, capable of harbouring the parasite and transmitting it to naive individuals. After eight years on the European market, few studies have been released on CaniLeish (R) vaccine safety and efficacy. The present study, a one-year randomized CaniLeish (R) vaccine field trial, was performed in a canine leishmaniosis endemic area and included animals selected from a native dog population (n = 168). No severe adverse reactions were observed in vaccinated dogs (n = 85). Cases of active L. infantum infection were detected by serological, molecular and clinical follow-up of dogs. One-year post-vaccination, no differences in number or severity of L. infantum active infections were observed between study groups (n = 4 in each group). Vaccine-induced cellular immunity, assessed through interferon-gamma quantification, showed significantly higher levels of this cytokine one-month post-vaccination in the vaccine group (p < 0.001), but no differences were observed after nine months between trial groups (p = 0.078). These results fail to support the reported CaniLeish (R) efficacy in the prevention of active L. infantum infection in dogs from endemic areas and naturally exposed to the parasite.

Filiaciones:
Velez, R:
 Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain

 Univ Barcelona, Fac Farm & Ciencies Alimentacio, Dept Biol Sanitat & Medi Ambient, Seccio Parasitol, Barcelona, Spain

 Inst Nacl Saude Doutor Ricardo Jorge CEVDI INSA, Ctr Estudos Vetores & Doencas Infeciosas Dr Franc, Av Liberdade 5, P-2965575 Aguas De Moura, Portugal

Domenech, E:
 Hosp Vet Canis, Girona, Spain

Rodriguez-Cortes, A:
 Univ Autonoma Barcelona, Dept Farmacol Terapeut & Toxicol, Bellaterra, Spain

Barrios, D:
 Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain

Tebar, S:
 Univ Barcelona, Fac Farm & Ciencies Alimentacio, Dept Biol Sanitat & Medi Ambient, Seccio Parasitol, Barcelona, Spain

Fernandez-Arevalo, A:
 Univ Barcelona, Fac Farm & Ciencies Alimentacio, Dept Biol Sanitat & Medi Ambient, Seccio Parasitol, Barcelona, Spain

 Hosp Santa Creu & Sant Pau, Serv Microbiol, Barcelona, Spain

Aguilar, R:
 Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain

Dobano, C:
 Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain

Alberola, J:
 Univ Autonoma Barcelona, Dept Farmacol Terapeut & Toxicol, Bellaterra, Spain

Cairo, J:
 Hosp Vet Canis, Girona, Spain

Gallego, M:
 Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain

 Univ Barcelona, Fac Farm & Ciencies Alimentacio, Dept Biol Sanitat & Medi Ambient, Seccio Parasitol, Barcelona, Spain
ISSN: 0001706X
Editorial
ELSEVIER, RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS, Países Bajos
Tipo de documento: Article
Volumen: 205 Número:
Páginas:
WOS Id: 000525801200025
ID de PubMed: 32035053
imagen Green Accepted

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