Evaluation of canine leishmaniosis vaccine CaniLeish (R) under field conditions in native dog populations from an endemic Mediterranean area-A randomized controlled trial
Por:
Velez, R, Domenech, E, Rodriguez-Cortes, A, Barrios, D, Tebar, S, Fernandez-Arevalo, A, Aguilar, R, Dobano, C, Alberola, J, Cairo, J, Gallego, M
Publicada:
1 may 2020
Resumen:
Dog vaccination is considered an effective way of reducing Leishmania infantum infection incidence in the canine population, as well as its transmission to humans. However, the use of partially effective vaccines can have the detrimental effect of "masking" vaccinated asymptomatic carriers, capable of harbouring the parasite and transmitting it to naive individuals. After eight years on the European market, few studies have been released on CaniLeish (R) vaccine safety and efficacy. The present study, a one-year randomized CaniLeish (R) vaccine field trial, was performed in a canine leishmaniosis endemic area and included animals selected from a native dog population (n = 168). No severe adverse reactions were observed in vaccinated dogs (n = 85). Cases of active L. infantum infection were detected by serological, molecular and clinical follow-up of dogs. One-year post-vaccination, no differences in number or severity of L. infantum active infections were observed between study groups (n = 4 in each group). Vaccine-induced cellular immunity, assessed through interferon-gamma quantification, showed significantly higher levels of this cytokine one-month post-vaccination in the vaccine group (p < 0.001), but no differences were observed after nine months between trial groups (p = 0.078). These results fail to support the reported CaniLeish (R) efficacy in the prevention of active L. infantum infection in dogs from endemic areas and naturally exposed to the parasite.
Filiaciones:
Velez, R:
Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain
Univ Barcelona, Fac Farm & Ciencies Alimentacio, Dept Biol Sanitat & Medi Ambient, Seccio Parasitol, Barcelona, Spain
Inst Nacl Saude Doutor Ricardo Jorge CEVDI INSA, Ctr Estudos Vetores & Doencas Infeciosas Dr Franc, Av Liberdade 5, P-2965575 Aguas De Moura, Portugal
Domenech, E:
Hosp Vet Canis, Girona, Spain
Rodriguez-Cortes, A:
Univ Autonoma Barcelona, Dept Farmacol Terapeut & Toxicol, Bellaterra, Spain
Barrios, D:
Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain
Tebar, S:
Univ Barcelona, Fac Farm & Ciencies Alimentacio, Dept Biol Sanitat & Medi Ambient, Seccio Parasitol, Barcelona, Spain
Fernandez-Arevalo, A:
Univ Barcelona, Fac Farm & Ciencies Alimentacio, Dept Biol Sanitat & Medi Ambient, Seccio Parasitol, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Serv Microbiol, Barcelona, Spain
Aguilar, R:
Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain
Dobano, C:
Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain
Alberola, J:
Univ Autonoma Barcelona, Dept Farmacol Terapeut & Toxicol, Bellaterra, Spain
Cairo, J:
Hosp Vet Canis, Girona, Spain
Gallego, M:
Univ Barcelona, ISGlobal, Hosp Clin, Barcelona, Spain
Univ Barcelona, Fac Farm & Ciencies Alimentacio, Dept Biol Sanitat & Medi Ambient, Seccio Parasitol, Barcelona, Spain
Green Accepted
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