Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
Por:
Dieberger A.M., Obermayer-Pietsch B., Harreiter J., Desoye G., van Poppel M.N.M., Simmons D., Corcoy R., Perez J.M.A., Kautzky-Willer A., Damm P., Mathiesen E., Jensen D.M., Andersen L.L.T., Dunne F., Lapolla A., Dalfra M.G., Bertolotto A., Jelsma J.G.M., Galjaard S., Wender-Ozegowska E., Zawiejska A., Hill D., Devlieger R., Snoek F.J.
Publicada:
1 ene 2023
Ahead of Print:
1 jul 2023
Resumen:
Background/ObjectivesObesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex.Subjects/MethodsParticipants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI & GE; 29 kg/m(2) were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered.ResultsAlmost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (-0.520%; 95% CI: -1.011%, -0.031% and -4.649%; -7.876%, -1.432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (-0.145 & mu;g/l; -0.279 & mu;g/l, -0.005 & mu;g/l). No associations were found with birthweight or other cord blood parameters.ConclusionsMaternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy.
Filiaciones:
Dieberger A.M.:
Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
Obermayer-Pietsch B.:
Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
Division of Endocrinology and Diabetology, Endocrinology Lab Platform, Department of Internal Medicine and Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
Harreiter J.:
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Desoye G.:
Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria
van Poppel M.N.M.:
Institute of Human Movement Science, Sport and Health, University of Graz, Graz, Austria
Simmons D.:
Macarthur Clinical School, School of Medicine, Western Sydney University, Campbelltown, NSW, Australia
Corcoy R.:
Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
CIBER-BBN, ISCIII, Madrid, Spain
Perez J.M.A.:
Institut de Recerca de l’Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
CIBER-BBN, ISCIII, Madrid, Spain
Kautzky-Willer A.:
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Gender Institute Lapura, Gars am Kamp, Austria
Damm P.:
Department of Obstetrics and Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Mathiesen E.:
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Department of Endocrinology and Center for Pregnant Women with Diabetes,Rigshospitalet, Copenhagen, Denmark
Jensen D.M.:
Department of Endocrinology and Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
Andersen L.L.T.:
Department of Endocrinology and Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
Dunne F.:
Clinical Research Facility and College of Medicine Nursing and Health Sciences, University of Galway, Galway, Ireland
Lapolla A.:
Università Degli Studi di Padova, Padua, Italy
Dalfra M.G.:
Università Degli Studi di Padova, Padua, Italy
Bertolotto A.:
Azienda Ospedaliero Universitaria Pisa, Pisa, Italy
Jelsma J.G.M.:
Department of Public and Occupational Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Amsterdam Public Health Research Institute, Health Behaviors & Chronic Diseases, Amsterdam, Netherlands
Galjaard S.:
Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, Netherlands
Wender-Ozegowska E.:
Medical Faculty I, Poznan University of Medical Sciences, Poznan, Poland
Zawiejska A.:
Medical Faculty I, Poznan University of Medical Sciences, Poznan, Poland
Hill D.:
Lawson Health Research Institute, London, ON, Canada
Devlieger R.:
KU Leuven Department of Development and Regeneration: Pregnancy, Fetus and Neonate, Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium
Snoek F.J.:
Amsterdam Public Health Research Institute, Health Behaviors & Chronic Diseases, Amsterdam, Netherlands
Department of Medical Psychology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Green Published, hybrid, All Open Access, Hybrid Gold, Green
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