Effectiveness and safety of ustekinumab 90 mg in patients weighing 100 kg or less: a retrospective, observational, multicenter study
Por:
del Alcazar, E, Ferran, M, Lopez-Ferrer, A, Notario, J, Vidal, D, Riera, J, Aparicio, G, Gallardo, F, Vilarrasa, E, Alsina, M, Puig, L, Ferrandiz, C, Carrascosa, JM
Publicada:
2 abr 2020
Resumen:
Background: Scant information from clinical practice is available on the effectiveness and safety of ustekinumab (UST) 90 mg in patients with psoriasis weighing 100 kg or less. Objectives: To assess the effectiveness and safety at weeks 16 and 24 of UST 90 mg in patients with psoriasis weighing <= 100 kg, and to study the impact on clinical outcomes of body mass index (BMI) and prior exposure to UST 45 mg. Methods: A retrospective, observational, and multicenter study of 74 adult patients who were treated with UST 90 mg at least 24 weeks. Results: Mean (standard deviation [SD]) score on psoriasis area and severity index (PASI) was 7.9 (4.8) at baseline, 3.3 (3.5) at week 16, and 2.2 (2.4) at week 24, when 69.7% of the patients had a PASI under 3. Overweight and obese patients achieved a mean PASI of 2.2 by week 24 (p= .995). In patients who had previously been treated with UST 45 mg (52/74) with insufficient response, mean (SD) absolute PASI score was 2.7 (2.6) at week 24. No serious adverse events were reported. Conclusions: In patients who weigh 100 kg or less but are overweight or obese and do not present an adequate response with UST 45 mg, increasing the dose to UST 90 mg could be an alternative option.
Filiaciones:
del Alcazar, E:
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Dermatol, Badalona, Spain
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Dermatol, Crta Canyet S-N, Badalona, Spain
Ferran, M:
Univ Autonoma Barcelona, Hosp del Mar, Inst Mar Invest Med, Dept Dermatol,UAB, Barcelona, Spain
Lopez-Ferrer, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Dermatol, UAB, Barcelona, Spain
Notario, J:
Univ Barcelona, Hosp Univ Bellvitge, Dept Dermatol, Lhospitalet De Llobregat, Spain
Vidal, D:
Hosp St Joan Despi Moises Broggi, Dept Dermatol, St Joan Despi, Spain
Riera, J:
Univ Barcelona, Hosp Clin, Dept Dermatol, Barcelona, Spain
Aparicio, G:
Univ Autonoma Barcelona, Hosp Univ Vall dHebron, Dept Dermatol, UAB, Barcelona, Spain
Gallardo, F:
Univ Autonoma Barcelona, Hosp del Mar, Inst Mar Invest Med, Dept Dermatol,UAB, Barcelona, Spain
Vilarrasa, E:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Dermatol, UAB, Barcelona, Spain
Alsina, M:
Univ Barcelona, Hosp Clin, Dept Dermatol, Barcelona, Spain
Puig, L:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Dermatol, UAB, Barcelona, Spain
Ferrandiz, C:
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Dermatol, Badalona, Spain
Carrascosa, JM:
Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Dermatol, Badalona, Spain
Green Accepted
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