Regional, circuit and network heterogeneity of brain abnormalities in psychiatric disorders
Por:
Segal A., Parkes L., Aquino K., Kia S.M., Wolfers T., Franke B., Hoogman M., Beckmann C.F., Westlye L.T., Andreassen O.A., Zalesky A., Harrison B.J., Davey C.G., Soriano-Mas C., Cardoner N., Tiego J., Yücel M., Braganza L., Suo C., Berk M., Cotton S., Bellgrove M.A., Marquand A.F., Fornito A.
Publicada:
1 ene 2023
Ahead of Print:
14 ago 2023
Resumen:
The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case-control research, which relies on group mean comparisons. Here we present a comprehensive, multiscale characterization of the heterogeneity of gray matter volume (GMV) differences in 1,294 cases diagnosed with one of six conditions (attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, depression, obsessive-compulsive disorder and schizophrenia) and 1,465 matched controls. Normative models indicated that person-specific deviations from population expectations for regional GMV were highly heterogeneous, affecting the same area in <7% of people with the same diagnosis. However, these deviations were embedded within common functional circuits and networks in up to 56% of cases. The salience-ventral attention system was implicated transdiagnostically, with other systems selectively involved in depression, bipolar disorder, schizophrenia and attention-deficit/hyperactivity disorder. Phenotypic differences between cases assigned the same diagnosis may thus arise from the heterogeneous localization of specific regional deviations, whereas phenotypic similarities may be attributable to the dysfunction of common functional circuits and networks.
Filiaciones:
Segal A.:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia
Parkes L.:
Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States
Department of Psychiatry, Rutgers University, Piscataway, NJ, United States
Aquino K.:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia
School of Physics, University of Sydney, Sydney, NSW, Australia
BrainKey Inc, Palo alto, CA, United States
Kia S.M.:
Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands
Department of Psychiatry, University Medical Center Utrecht, Utrecht, Netherlands
Department of Cognitive Science and Artificial Intelligence, Tilburg University, Tilburg, Netherlands
Wolfers T.:
Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands
Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway
Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health (TÜCMH), University of Tübingen, Tübingen, Germany
Franke B.:
Department of Psychiatry, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands
Department of Human Genetics, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands
Hoogman M.:
Department of Psychiatry, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands
Department of Human Genetics, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands
Beckmann C.F.:
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands
Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands
Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom
Westlye L.T.:
Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway
Department of Psychology, University of Oslo, Oslo, Norway
KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway
Andreassen O.A.:
Norwegian Centre for Mental Disorders Research, Division of Mental Health and Addiction, University of Oslo and Oslo University Hospital, Oslo, Norway
KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway
Zalesky A.:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, VIC, Australia
Department of Biomedical Engineering, The University of Melbourne, Melbourne, VIC, Australia
Harrison B.J.:
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, VIC, Australia
Davey C.G.:
Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia
Soriano-Mas C.:
Department of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute, Barcelona, Spain
Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain
Department of Social Psychology and Quantitative Psychology, Universitat de Barcelona, Barcelona, Spain
Cardoner N.:
Centro de Investigación Biomédica en Red de Salud Mental, Carlos III Health Institute, Madrid, Spain
Sant Pau Mental Health Research Group, Institut d’Investigació Biomèdica Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain
Tiego J.:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia
Yücel M.:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
Braganza L.:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
Suo C.:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia
Australian Characterisation Commons at Scale (ACCS) Project, Monash eResearch Centre, Melbourne, VIC, Australia
Berk M.:
Institute for Mental and Physical Health and Clinical Translation School of Medicine, Deakin University, Geelong, VIC, Australia
Orygen, Melbourne, Vic, Australia
Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia
Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia
Cotton S.:
Orygen, Melbourne, Vic, Australia
Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia
Bellgrove M.A.:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
Marquand A.F.:
Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands
Department of Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands
Department of Neuroimaging, Centre of Neuroimaging Sciences, Institute of Psychiatry, King’s College London, London, United Kingdom
Fornito A.:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia
Monash Biomedical Imaging, Monash University, Melbourne, VIC, Australia
hybrid, Green Submitted, Green Published, All Open Access, Hybrid Gold, Green
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