Correlation between C-reactive protein and the inflammatory ratios in acute schizophrenia inpatients: are they associated?
Por:
Llorca-Bofi, V, Bioque, M, Font, M, Gich, I, Mur, M
Publicada:
1 sep 2023
Ahead of Print:
19 jul 2023
Resumen:
C-reactive protein (CRP) and inflammatory ratios have been proposed to study immune dysregulation in schizophrenia. Nevertheless, links between CRP and inflammatory ratios in acute SCZ inpatients have been understudied. This study investigated the relationship between CRP and inflammatory ratios (Neutrophil-Lymphocyte Ratio [NRL], Platelet-Lymphocyte Ratio [PLR], Monocyte-Lymphocyte ratio [MLR] and Basophil-Lymphocyte Ratio [BLR]) in a total of 698 acute SCZ inpatients; and analysed how this relationship is affected by sex and type of episode. CRP correlated with NLR (rs = 0.338, p < 0.001), PLR (rs = 0.271, p < 0.001) and MLR (rs = 0.148, p < 0.001) but not with BLR (rs = 0.059, p = 0.121). Multiple lineal regression analysis showed that high levels of NLR, MLR and PLR but not BLR were independently associated with high CRP levels. No sex-related variations were found. Significant associations were maintained for NLR and MLR in first-episode and multiepisode SCZ, although the strength of the association was stronger in multiepisode SCZ. Again, no sex-related differences were found in these associations. In conclusion, inflammatory ratios were low to moderately associated with CRP in acute SCZ inpatients. NLR and multiepisode SCZ showed the highest associations with CRP. Future studies should consider inflammatory ratios not as a substitute for CRP but as a complementary biomarker.
Filiaciones:
Llorca-Bofi, V:
Univ Barcelona, Dept Med, Barcelona, Spain
Santa Maria Univ Hosp Lleida, Dept Psychiat, Lleida, Spain
Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain
Bioque, M:
Univ Barcelona, Dept Med, Barcelona, Spain
Hosp Clin Barcelona, Neurosci Inst, CIBERSAM, IDIBAPS,Barcelona Clin Schizophrenia Unit BCSU, Barcelona, Spain
Font, M:
Arnau Vilanova Univ Hosp, Lab Dept, Lleida, Spain
Gich, I:
St Pau Biomed Res Inst IIB St Pau, CIBER Epidemiol & Salud Publ CIBERESP, Dept Clin Epidemiol & Publ Hlth, HSCSP, Barcelona, Spain
Mur, M:
Univ Lleida, Dept Med & Surg, Lleida, Spain
Santa Maria Univ Hosp Lleida, Dept Psychiat, Lleida, Spain
Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain
hybrid, All Open Access; Hybrid Gold
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