Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/ Dependency) Classification Correlates with Disease Severity and Quality of Life
Por:
Santos-Garcia, D, Fonticoba, TD, Bartolome, CC, Painceiras, MJF, Iniguez-Alvarado, MC, Diaz, IG, Jesus, S, Buongiorno, MT, Planellas, L, Cosgaya, M, Caldentey, JG, Caballol, N, Legarda, I, Vara, JH, Cabo, I, Manzanares, LL, Aramburu, IG, Rivera, MAA, Mayordomo, VG, Nogueira, V, Puente, V, Garcia-Sotos, JD, Borrue, C, Vila, BS, Sauco, MA, Vela, L, Escalante, S, Cubo, E, Padilla, FC, Castrillo, JCM, Alonso, PS, Losada, MGA, Ariztegui, NL, Gaston, I, Kulisevsky, J, Gonzalez, MM, Seijo, M, Martinez, JR, Valero, C, Kurtis, M, Ardura, JG, Redondo, RA, Ordas, C, Diaz, LML, McAfee, D, Calopa, M, Carrillo, F, Sevilla, FE, Freire-Alvarez, E, Esteban, JCG, Ramos, RG, Luquin, MRI, Martinez-Torres, I, Ignacio, AS, Martinez-Martin, P, Mir, P
Publicada:
1 ene 2023
Resumen:
Background: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL: 1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05 +/- 7.84 years old; 59% males) were included. MNCD stage was: stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advanced MNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p < 0.0001) and EUROHIS-QOL8 (p < 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD.
Filiaciones:
Santos-Garcia, D:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Fonticoba, TD:
Complejo Hosp Univ Ferrol, La Coruna, Spain
Bartolome, CC:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Painceiras, MJF:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Iniguez-Alvarado, MC:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Diaz, IG:
Complejo Hosp Univ A Coruna, La Coruna, Spain
Jesus, S:
Univ Seville, Unidad Trastornos Movimiento, CSIC, Inst Biomed Sevilla,Serv Neurol & Neurofisiol,Hos, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Buongiorno, MT:
Hosp Univ Mutua Terrassa, Barcelona, Spain
Planellas, L:
Clin Pilar, Barcelona, Spain
Cosgaya, M:
Hosp Clin Barcelona, Barcelona, Spain
Caldentey, JG:
Ctr Neurol Oms 42, Palma de Mallorca, Spain
Caballol, N:
Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
Legarda, I:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Vara, JH:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Univ Vall dHebron, Barcelona, Spain
Cabo, I:
Complejo Hosp Univ Pontevedra, Pontevedra, Spain
Manzanares, LL:
Hosp Univ La Princesa, Madrid, Spain
Aramburu, IG:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Univ Marques de Valdecilla, Santander, Spain
Rivera, MAA:
Hosp Gen LHospitalet, Consorci Sanitari Integral, Barcelona, Spain
Mayordomo, VG:
Hosp Univ Clin San Carlos, Madrid, Spain
Nogueira, V:
Hosp Costa, Lugo, Spain
Puente, V:
Hosp Mar, Barcelona, Spain
Garcia-Sotos, JD:
Hosp Univ Virgen Macarena, Seville, Spain
Borrue, C:
Hosp Infanta Sofia, Madrid, Spain
Vila, BS:
Inst Catala Salut, Inst Assistencia Sanitaria, Girona, Spain
Sauco, MA:
Hosp Gen Univ Elche, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Escalante, S:
Hosp Tortosa Verge Cinta, Tarragona, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Padilla, FC:
Hosp Univ Canarias, San Cristobal De Laguna, Santa Cruz De T, Spain
Castrillo, JCM:
Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain
Alonso, PS:
Hosp Univ Puerta Hierro, Madrid, Spain
Losada, MGA:
Complejo Hosp Univ Vigo, Hosp Alvaro Cunqueiro, Vigo, Spain
Ariztegui, NL:
Complejo Hosp Toledo, Toledo, Spain
Gaston, I:
Complejo Hosp Navarra, Pamplona, Spain
Kulisevsky, J:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Gonzalez, MM:
Hosp Univ Cent Asturias, Oviedo, Spain
Seijo, M:
Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
Martinez, JR:
Hosp Univ Donostia, San Sebastian, Spain
Valero, C:
Hosp Arnau Vilanova, Valencia, Spain
Kurtis, M:
Hosp Ruber Int, Madrid, Spain
Ardura, JG:
Hosp Cabuenes, Gijon, Spain
Redondo, RA:
Hosp Univ Lucus Augusti, Lugo, Spain
Ordas, C:
Hosp Rey Juan Carlos, Madrid, Spain
Diaz, LML:
Complejo Hosp Univ Vigo, Hosp Alvaro Cunqueiro, Vigo, Spain
McAfee, D:
Univ Maryland, Sch Med, College Pk, MD 20742 USA
Calopa, M:
Hosp Univ Bellvitge, Serv Neurol, Unidad Trastornos Movimiento, Barcelona, Spain
Carrillo, F:
Univ Seville, Unidad Trastornos Movimiento, CSIC, Inst Biomed Sevilla,Serv Neurol & Neurofisiol,Hos, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Sevilla, FE:
Hosp Univ Virgen Nieves, Inst Invest Biosanitaria Ibs GRANADA, Serv Neurol, Unidad Trastornos Movimiento, Granada, Spain
Freire-Alvarez, E:
Hosp Gen Univ Elche, Elche, Spain
Esteban, JCG:
Hosp Cruces, Bilbao, Spain
Ramos, RG:
Hosp Univ Clin San Carlos, Madrid, Spain
Luquin, MRI:
Clin Univ Navarra, Inst Invest Sanitaria Navarra, Pamplona, Spain
Martinez-Torres, I:
Hosp Univ & Politecn La Fe, Valencia, Spain
Ignacio, AS:
Complejo Hosp Univ Santiago de Compostela, Santiago De Compostela, A Coruna, Spain
Martinez-Martin, P:
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Mir, P:
Univ Seville, Unidad Trastornos Movimiento, CSIC, Inst Biomed Sevilla,Serv Neurol & Neurofisiol,Hos, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
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