Economic Consequences of the Overuse of Short-Acting ?-Adrenergic Agonists in the Treatment of Asthma in Spain
Por:
Valero A., Molina J., Nuevo J., Simon S., Capel M., Sicras-Mainar A., Sicras-Navarro A., Plaza V.
Publicada:
1 ene 2023
Ahead of Print:
26 nov 2021
Resumen:
Objective: To determine the relationship between short-acting ss-adrenergic agonist (SABA) overuse and health care resource use and costs in asthma patients in routine clinical practice.Methods: A longitudinal retrospective study was conducted in Spanish primary and specialized care centers using the BIG-PAC medical records database. The study population comprised asthma patients >= 12 years of age who attended >= 2 consultations during 2017 and had 1-year follow-up data available. The main outcomes were demographics, comorbidities, medication, and clinical and health care resource use and costs. The relationship between SABA overuse and health care costs and between asthma severity and health care costs was determined.Results: The SABA use IN Asthma (SABINA) study included 39 555 patients, with a mean (SD) age of 49.8 (20.7) years (64.2% female). The Charlson comorbidity index was 0.7 (1.0). SABA overuse (>= 3 canisters/y) was 28.7% (95%CI, 27.7-29.7), with a mean of 3.3 (3.6) canisters/y. Overall, 5.1% of patients were prescribed >= 12 canisters/y. SABA overuse was correlated with health care costs (rho=0.621; P<.001). The adjusted mean annual cost/patient according to the Global Initiative for Asthma (GINA 2019) classification of asthma severity was euro2231, euro2345, euro2735, euro3473, and euro4243 for steps 1-5, respectively (P<.001). Regardless of asthma severity, SABA overuse yielded a significant increase in health care costs per patient and year (euro5702 vs euro1917, P<.001) compared with recommended use (<2 canisters/y).Conclusion: SABA overuse yields high costs for the Spanish National Health System. Costs increased with severity of asthma.
Filiaciones:
Valero A.:
Hosp Clin Barcelona, Serv Alergol, Barcelona, Spain
Univ Barcelona, IDIBAPS, Barcelona, Spain
CIBER Enfermedades Resp CIBERES, Barcelona, Spain
Hosp Clin Barcelona, C Villarroel 170, Barcelona 08036, Spain
Molina J.:
CS Francia, Direcc Asistencial Oeste, Madrid, Spain
Nuevo J.:
AstraZeneca, Dept Med Evidence & Hlth Econ, Madrid, Spain
Simon S.:
AstraZeneca, Dept Med Evidence & Hlth Econ, Madrid, Spain
Capel M.:
AstraZeneca, Dept Med Evidence & Hlth Econ, Madrid, Spain
Sicras-Mainar A.:
Real Life Data, Hlth Econ & Outcomes Res, Barcelona, Spain
Sicras-Navarro A.:
Real Life Data, Hlth Econ & Outcomes Res, Barcelona, Spain
Plaza V.:
Hosp Santa Creu & Sant Pau, Serv Pneumol & Allergia, Barcelona, Spain
Inst Invest Biomed St Pau IIB St Pau, Barcelona, Spain
Univ Autonoma Barcelona, Barcelona, Spain
gold, All Open Access; Bronze
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