Brain glucose metabolism and gray matter volume in retired professional soccer players: a cross-sectional [F-18]FDG-PET/MRI study
Por:
Aranha M.R., Coutinho A.M., Carneiro, CD, Pastorello B.F., Studart-Neto A., Guariglia C.C., Tsunemi M.H., Moreira, ELS, Ianof J.N., Anghinah R., Nitrini R., Cerri G.G., Fortea J., Buchpiguel C.A., Leite C.C.
Publicada:
31 may 2023
Ahead of Print:
31 may 2023
Resumen:
Background Professional soccer athletes are exposed to repetitive head impacts and are at risk of developing chronic traumatic encephalopathy.
Objective To evaluate regional brain glucose metabolism (rBGM) and gray matter (GM) volume in retired soccer players (RSPs).
Methods Male RSPs and age and sex-matched controls prospectively enrolled between 2017 and 2019 underwent neurological and neuropsychological evaluations, brain MRI and [F-18]FDG-PET in a 3.0-Tesla PET/MRI scanner. Visual analysis was performed by a blinded neuroradiologist and a blinded nuclear physician. Regional brain glucose metabolism and GM volume were assessed using SPM8 software. Groups were compared using appropriate statistical tests available at SPM8 and R.
Results Nineteen RSPs (median [IQR]: 62 [50-64.5] years old) and 20 controls (60 [48-73] years old) were included. Retired soccer players performed worse on mini-mental state examination, digit span, clock drawing, phonemic and semantic verbal fluency tests, and had reduced rBGM in the left temporal pole (pFDR = 0.008) and the anterior left middle temporal gyrus (pFDR = 0.043). Semantic verbal fluency correlated with rBGM in the right hippocampus, left temporal pole, and posterior left middle temporal gyrus (p <= 0.042). Gray matter volume reduction was observed in similar anatomic regions but was less extensive and did not survive correction for multiple comparisons (pFDR >= 0.085). Individual [18F]FDG-PET visual analysis revealed seven RSPs with overt hypometabolism in the medial and lateral temporal lobes, frontal lobes, and temporoparietal regions. Retired soccer players had a higher prevalence of septum pellucidum abnormalities on MRI.
Conclusion Retired soccer players had reduced rBGM and GM volume in the temporal lobes and septum pellucidum abnormalities, findings possibly related to repetitive head impacts.
Filiaciones:
Aranha M.R.:
Univ Sao Paulo, Fac Med, Inst Radiol, Sao Paulo, SP, Brazil
Univ Sao Paulo, Fac Med, Ctr Med Nucl, Sao Paulo, SP, Brazil
Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Inst Recerca, Fac Med, Barcelona, Spain
Coutinho A.M.:
Univ Sao Paulo, Fac Med, Ctr Med Nucl, Sao Paulo, SP, Brazil
Carneiro, CD:
Univ Sao Paulo, Fac Med, Ctr Med Nucl, Sao Paulo, SP, Brazil
Pastorello B.F.:
Univ Sao Paulo, Fac Med, Inst Radiol, Sao Paulo, SP, Brazil
Studart-Neto A.:
Univ Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil
Guariglia C.C.:
Univ Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil
Tsunemi M.H.:
Univ Estadual Paulista, Dept Bioestat, Inst Biociencias, Botucatu, SP, Brazil
Moreira, ELS:
Univ Sao Paulo, Fac Med, Inst Radiol, Sao Paulo, SP, Brazil
Ianof J.N.:
Univ Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil
Anghinah R.:
Univ Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil
Nitrini R.:
Univ Sao Paulo, Fac Med, Dept Neurol, Sao Paulo, SP, Brazil
Cerri G.G.:
Univ Sao Paulo, Fac Med, Inst Radiol, Sao Paulo, SP, Brazil
Fortea J.:
Univ Autonoma Barcelona, Hosp Santa Creu & Sant Pau, Inst Recerca, Fac Med, Barcelona, Spain
Fdn Catalana Sindrome, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Buchpiguel C.A.:
Univ Sao Paulo, Fac Med, Ctr Med Nucl, Sao Paulo, SP, Brazil
Leite C.C.:
Univ Sao Paulo, Fac Med, Inst Radiol, Sao Paulo, SP, Brazil
gold, Green Published, All Open Access, Gold, Green
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