Consumption of ultra-processed foods is associated with depression, mesocorticolimbic volume, and inflammation
Por:
Contreras-Rodriguez, O, Reales-Moreno, M, Fernandez-Barres, S, Cimpean, A, Arnoriaga-Rodriguez, M, Puig, J, Biarnes, C, Motger-Alberti, A, Cano, M, Fernandez-Real, JM
Publicada:
15 ago 2023
Ahead of Print:
1 may 2023
Resumen:
Background: The consumption of ultra-processed foods and drinks (UPF) has been associated with depression and inflammation and preclinical studies showed that some UPF components disrupt the amygdala-hippocampal complex. We combine diet, clinical and brain imaging data to investigate the relationship between the UPF consumption, depressive symptoms, and brain volumes in humans, considering interactions with obesity, and the mediation effect of inflammation biomarkers.Methods: One-hundred fifty-two adults underwent diet, depressive symptoms, anatomic magnetic resonance imaging assessments and laboratory tests. Relationships between the % of UPF consumption (in grams) of the total diet, depressive symptoms, and gray matter brain volumes were explored using several adjusted regression models, and in interaction with the presence of obesity. Whether inflammatory biomarkers (i.e., white blood cell count, lipopolysaccharide-binding protein, c-reactive protein) mediate the previous associations was investigated using R mediation package. Results: High UPF consumption was associated with higher depressive symptoms in all participants (beta = 0.178, CI = 0.008-0.261) and in those with obesity (beta = 0.214, CI = - 0.004-0.333). Higher consumption was also associated with lower volumes in the posterior cingulate cortex and the left amygdala, which in the participants with obesity also encompassed the left ventral putamen and the dorsal frontal cortex. White blood count levels mediated the association between UPF consumption and depressive symptoms (p = 0.022).Limitations: The present study precludes any causal conclusions.Conclusions: UPF consumption is associated with depressive symptoms and lower volumes within the meso-corticolimbic brain network implicated in reward processes and conflict monitoring. Associations were partially dependent on obesity and white blood cell count.
Filiaciones:
Contreras-Rodriguez, O:
Josep Trueta Univ Hosp, Girona Biomed Res Inst IdIBGi, Dept Radiol Med Imaging IDI, Girona, Spain
Univ Autonoma Barcelona, Fac Med, Dept Psychiat & Legal Med, Bellaterra, Spain
Hlth Inst Carlos III ISCIII, Madrid, Spain
CIBERSAM, Madrid, Spain
Reales-Moreno, M:
Josep Trueta Univ Hosp, Girona Biomed Res Inst IdIBGi, Dept Radiol Med Imaging IDI, Girona, Spain
Univ Girona, Sch Med, Dept Med Sci, Girona, Spain
Fernandez-Barres, S:
Agencia Salut Publ Barcelona, Pl Lesseps 1, Barcelona 08023, Spain
Cimpean, A:
Josep Trueta Univ Hosp, Girona Biomed Res Inst IdIBGi, Dept Radiol Med Imaging IDI, Girona, Spain
Arnoriaga-Rodriguez, M:
Univ Girona, Sch Med, Dept Med Sci, Girona, Spain
Josep Trueta Univ Hosp, Girona Biomed Res Inst IdIBGi, Dept Diabet Endocrinol & Nutr UDEN, Girona, Spain
CIBER Fisiopatol Obes & Nutr CIBEROBN, Girona, Spain
Puig, J:
Josep Trueta Univ Hosp, Girona Biomed Res Inst IdIBGi, Dept Radiol Med Imaging IDI, Girona, Spain
Univ Girona, Sch Med, Dept Med Sci, Girona, Spain
Inst Diagnost Imaging, IDI Res Unit IDIR, Parc Sanitari Pere Virgili, Barcelona, Spain
Biarnes, C:
Josep Trueta Univ Hosp, Girona Biomed Res Inst IdIBGi, Dept Radiol Med Imaging IDI, Girona, Spain
Motger-Alberti, A:
Univ Girona, Sch Med, Dept Med Sci, Girona, Spain
Josep Trueta Univ Hosp, Girona Biomed Res Inst IdIBGi, Dept Diabet Endocrinol & Nutr UDEN, Girona, Spain
CIBER Fisiopatol Obes & Nutr CIBEROBN, Girona, Spain
Cano, M:
Hlth Inst Carlos III ISCIII, Madrid, Spain
CIBERSAM, Madrid, Spain
Hosp Santa Creu i Sant Pau, Inst Invest Biomed Sant Pau IIB Sant Pau, Sant Pau Mental Hlth Res Grp, Barcelona, Spain
Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Barcelona, Spain
Fernandez-Real, JM:
Univ Girona, Sch Med, Dept Med Sci, Girona, Spain
Josep Trueta Univ Hosp, Girona Biomed Res Inst IdIBGi, Dept Diabet Endocrinol & Nutr UDEN, Girona, Spain
CIBER Fisiopatol Obes & Nutr CIBEROBN, Girona, Spain
hybrid, All Open Access; Hybrid Gold
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