Epidemiology and antimicrobial resistance profile of Neisseria gonorrhoeae in Catalonia, Spain, 2016-2019
Por:
Herrero, M, Broner, S, Cruells, A, Esteve, S, Ferre, L, Mendioroz, J, Jane, M, Pitart, C
Publicada:
10 may 2023
Ahead of Print:
1 may 2023
Resumen:
Antimicrobial resistance data for Neisseria gonorrhoeae is globally sparse and resistant strains are emerging in Catalonia. We aim to describe epidemiological and antimicrobial resistance in all patients infected with N. gonorrhoeae during the period from 2016 to 2019, using available antimicrobial susceptibility data. We retrospectively analysed confirmed N. gonorrhoeae cases notified to Catalonia's microbiological reporting system. Antibiotic susceptibility testing (azithromycin, cefixime, ceftriaxone, ciprofloxacin, penicillin, spectinomycin, and tetracycline) was assessed using clinical breakpoints published by the European Committee on Antimicrobial Susceptibility Testing. Incidence rates were calculated and proportions were compared using the chi(2) test or Fisher's exact test, and analysed using the Statistical Package for Social Sciences (SPSS 18.0). A total of 14,251 confirmed cases of N. gonorrhoeae were notified. Incidence increased from 30.7 cases/100,000 person-years (p < 0.001) in 2016 to 64.7 in 2019. Culture was available in 6,292 isolates (44.2%), of which 5,377 (85.5%) were resistant to at least one of the antibiotics tested. Azithromycin resistance rose from 6.1% in 2016 to 16% in 2019 (p < 0.001). Only 1.0% (45 cases) were resistant to ceftriaxone. Multidrug-resistant N. gonorrhoeae increased from 0.25% in 2016 to 0.42% in 2019 (p = 0.521). One case presented extensively drug-resistant N. gonorrhoeae. In Catalonia, 10% of the N. gonorrhoeae isolates were resistant to azithromycin in the 2016-2019 period. According to World Health Organization guidelines, resistance above 5% indicates an alert to review treatment guidelines. Antimicrobial susceptibility testing in clinical practice followed by surveillance and interventions are essential to monitor trends and prevent the spread of antimicrobial resistance.
Filiaciones:
Herrero, M:
Catalan Publ Hlth Agcy, Subdirectorate Gen Publ Hlth Surveillance & Emerge, Govt Catalonia, Barcelona 08005, Spain
Broner, S:
Catalan Publ Hlth Agcy, Subdirectorate Gen Publ Hlth Surveillance & Emerge, Govt Catalonia, Barcelona 08005, Spain
Cruells, A:
Catalan Publ Hlth Agcy, Subdirectorate Gen Publ Hlth Surveillance & Emerge, Govt Catalonia, Barcelona 08005, Spain
Esteve, S:
Catalan Publ Hlth Agcy, Subdirectorate Gen Publ Hlth Surveillance & Emerge, Govt Catalonia, Barcelona 08005, Spain
Ferre, L:
Catalan Publ Hlth Agcy, Subdirectorate Gen Publ Hlth Surveillance & Emerge, Govt Catalonia, Barcelona 08005, Spain
Mendioroz, J:
Catalan Publ Hlth Agcy, Subdirectorate Gen Publ Hlth Surveillance & Emerge, Govt Catalonia, Barcelona 08005, Spain
Jordi Gol i Gurina Univ Res Inst Primary Hlth Care, Res Support Unit Cent Catalonia, Sant Fruitos De Bages 08272, Spain
Jane, M:
Catalan Publ Hlth Agcy, Subdirectorate Gen Publ Hlth Surveillance & Emerge, Govt Catalonia, Barcelona 08005, Spain
Carlos III Hlth Inst, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Univ Barcelona, Dept Med, Barcelona, Spain
Pitart, C:
Hospital Clinic Barcelona, Barcelona, Spain
Green Published, hybrid, All Open Access, Hybrid Gold, Green
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