Incidence and Prognosis of Colorectal Cancer After Heart Transplantation: Data From the Spanish Post-Heart Transplant Tumor Registry
Por:
Sagastagoitia-Fornie M., Morán-Fernández L., Blázquez-Bermejo Z., Díaz-Molina B., Gómez-Bueno M., Almenar-Bonet L., López-Granados A., González-Vílchez F., Mirabet-Pérez S., García-Romero E., Jose, MSM, Juan-Aracil, GR, Castel-Lavilla M.A., Blasco-Peiro T., Garrido-Bravo I., De La Fuente-Galán L., Muniz, J, Crespo-Leiro M.G.
Publicada:
19 may 2023
Ahead of Print:
19 may 2023
Resumen:
In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for age-at-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.
Filiaciones:
Sagastagoitia-Fornie M.:
Ferrol Univ Hosp Complex, Ferrol, Spain
Morán-Fernández L.:
Univ Hosp October 12, Madrid, Spain
Blázquez-Bermejo Z.:
Gregorio Maranon Hosp, Madrid, Spain
Díaz-Molina B.:
Cent Univ Hosp Asturias, Oviedo, Spain
Gómez-Bueno M.:
Puerta De Hierro Univ Hosp Majadahonda, Madrid, Spain
Almenar-Bonet L.:
La Fe Hosp, Valencia, Spain
López-Granados A.:
Hosp Univ Reina Sofia, Cordoba, Spain
González-Vílchez F.:
Marques De Valdecilla Univ Hosp, Santander, Spain
Mirabet-Pérez S.:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Barcelona, Spain
García-Romero E.:
Bellvitge Univ Hosp, Barcelona, Spain
Jose, MSM:
Virgen Del Rocio Univ Hosp, Seville, Spain
Juan-Aracil, GR:
Univ Clin Navarra, Pamplona, Spain
Castel-Lavilla M.A.:
Hosp Clin Barcelona, Barcelona, Spain
Blasco-Peiro T.:
Hosp Univ Miguel Servet, Zaragoza, Spain
Garrido-Bravo I.:
Hosp Univ Virgen de la Arrixaca, Murcia, Spain
De La Fuente-Galán L.:
Hosp Clin Univ Valladolid, Valladolid, Spain
Muniz, J:
Univ A Coruna, Grp Invest Cardiovasc GRINCAR, La Coruna, Spain
Crespo-Leiro M.G.:
A Coruna Univ Hosp Complex CHUAC, La Coruna, Spain
gold, All Open Access, Gold
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