Tobacco Smoking and Second-Hand Smoke Exposure Impact on Tuberculosis in Children
Por:
Altet, N, Latorre, I, Jimenez-Fuentes, MA, Soriano-Arandes, A, Villar-Hernandez, R, Mila, C, Rodriguez-Fernandez, P, Muriel-Moreno, B, Comella-del-Barrio, P, Godoy, P, Millet, JP, de Souza-Galvao, ML, Jimenez-Ruiz, CA, Dominguez, J
Publicada:
1 abr 2022
Resumen:
Little is known about whether second-hand smoke (SHS) exposure affects tuberculosis (TB). Here, we investigate the association of cigarette smoke exposure with active TB and latent TB infection (LTBI) in children, analyzing Interferon-Gamma Release Assays' (IGRAs) performance and cytokine immune responses. A total of 616 children from contact-tracing studies were included and classified regarding their smoking habits [unexposed, SHS, or smokers]. Risk factors for positive IGRAs, LTBI, and active TB were defined. GM-CSF, IFN-gamma, IL-2, IL-5, IL-10, IL-13, IL-22, IL-17, TNF-alpha, IL-1RA and IP-10 cytokines were detected in a subgroup of patients. Being SHS exposed was associated with a positive IGRA [aOR (95% CI): 8.7 (5.9-12.8)] and was a main factor related with LTBI [aOR (95% CI): 7.57 (4.79-11.94)] and active TB [aOR (95% CI): 3.40 (1.45-7.98)]. Moreover, IGRAs' sensitivity was reduced in active TB patients exposed to tobacco. IL-22, GM-CSF, IL-5, TNF-alpha, IP-10, and IL-13 were less secreted in LTBI children exposed to SHS. In conclusion, SHS is associated with LTBI and active TB in children. In addition, false-negative IGRAs obtained on active TB patients exposed to SHS, together with the decrease of specific cytokines released, suggest that tobacco may alter the immune response.
Filiaciones:
Altet, N:
Hosp Univ Vall dHebron, Unitat TB Vall dHebron Drassanes, Barcelona 08001, Spain
Unitat Clin Tractament Directament Observat TB, Serv Clin, Barcelona 08022, Spain
Latorre, I:
Univ Autonoma Barcelona, CIBER Enfermedades Resp, Inst Invest Germans Trias & Pujol, Badalona 08916, Spain
Jimenez-Fuentes, MA:
Hosp Univ Vall dHebron, Unitat TB Vall dHebron Drassanes, Barcelona 08001, Spain
Soriano-Arandes, A:
Hosp Univ Vall dHebron, Unitat TB Vall dHebron Drassanes, Barcelona 08001, Spain
Villar-Hernandez, R:
Univ Autonoma Barcelona, CIBER Enfermedades Resp, Inst Invest Germans Trias & Pujol, Badalona 08916, Spain
Mila, C:
Hosp Univ Vall dHebron, Unitat TB Vall dHebron Drassanes, Barcelona 08001, Spain
Rodriguez-Fernandez, P:
Univ Autonoma Barcelona, CIBER Enfermedades Resp, Inst Invest Germans Trias & Pujol, Badalona 08916, Spain
Inst Biotecnol & Biomed, Cerdanyola Del Valles 08193, Spain
Muriel-Moreno, B:
Univ Autonoma Barcelona, CIBER Enfermedades Resp, Inst Invest Germans Trias & Pujol, Badalona 08916, Spain
Comella-del-Barrio, P:
Univ Autonoma Barcelona, CIBER Enfermedades Resp, Inst Invest Germans Trias & Pujol, Badalona 08916, Spain
Godoy, P:
Generalitat Catalunya, Dept Salut, Barcelona 08028, Spain
CIBER Epidemiol & Salud Publ, Madrid 28029, Spain
Univ Lleida, IRB Lleida, Lleida 25198, Spain
Millet, JP:
Unitat Clin Tractament Directament Observat TB, Serv Clin, Barcelona 08022, Spain
CIBER Epidemiol & Salud Publ, Madrid 28029, Spain
de Souza-Galvao, ML:
Hosp Univ Vall dHebron, Unitat TB Vall dHebron Drassanes, Barcelona 08001, Spain
Jimenez-Ruiz, CA:
Unidad Tabaquismo Comunidad Autonoma Madrid, Madrid 28015, Spain
Dominguez, J:
Univ Autonoma Barcelona, CIBER Enfermedades Resp, Inst Invest Germans Trias & Pujol, Badalona 08916, Spain
gold, Green Published
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